DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF675

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_612203.2	Gene:	ZNF675 / 171392	HGNCID:	30768	Length:	568	Species:	Homo sapiens

Alignment Length:	322	Identity:	116/322 - (36%)
Similarity:	167/322 - (51%)	Gaps:	12/322 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 QLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHIT 141
            :.||...:.:|.|     |.:|.|.|...:.|..|.:||:.|:|:||::|||::.|..||..| .
Human   245 EYKKDYAREKPYK-----CEECGKAFNQSSHLTTHKIIHTGEKPYKCEECGKAFNQFSNLTTH-K 303

  Fly   142 TAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQ 206
            ..|...:.::|.:|.|:|.....|..|.|:|:|||||.|:.|.|.|.|..:|.:|...|  |..|
Human   304 KIHTGEQPYICEECGKAFTQSSTLTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKNIH--TGEQ 366

  Fly   207 QFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICH 271
            .:.|.:|..:|:.::||..|.:.|.:...::|..|...|.:..||..| .:.|.....::||.|.
Human   367 PYKCEECGKAFNRSSNLTEHRKIHTEEKPYKCKECGKAFKHSSALTTH-KRIHTGEKPYKCEECG 430

  Fly   272 KMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVL 336
            |.......|..|.:.||..|.:.||.|...|.|.|:...|.::|:||.||:|..|.:.|.|||.|
Human   431 KAFNRSSKLTEHKKLHTGKKPYKCEECGKAFIQSSKLTEHKKIHSGEIPYKCEECGKAFKHSSSL 495

  Fly   337 KLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH 398
            ..|.|.||||||::|:.|..  |||:.:.|..| |.||..:|||.||.|...|.....|..|
Human   496 TTHKRIHTGEKPYKCEECGK--AFSRSSKLTEH-KIIHTGEKPYKCERCDKAFNQSANLTKH 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/158 (34%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	61/176 (35%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	6/17 (35%)
ZNF675	NP_612203.2	KRAB	4..62	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	169..556	CDD:227381	116/322 (36%)
		C2H2 Zn finger	174..194	CDD:275370
		C2H2 Zn finger	202..222	CDD:275368
		C2H2 Zn finger	230..250	CDD:275368	2/4 (50%)
		C2H2 Zn finger	258..278	CDD:275368	6/19 (32%)
		zf-H2C2_2	270..295	CDD:290200	11/24 (46%)
		C2H2 Zn finger	286..306	CDD:275368	8/20 (40%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		zf-H2C2_2	327..351	CDD:290200	13/23 (57%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
		zf-H2C2_2	382..407	CDD:290200	7/24 (29%)
		C2H2 Zn finger	398..418	CDD:275368	6/20 (30%)
		zf-H2C2_2	410..435	CDD:290200	8/25 (32%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..474	CDD:275368	7/19 (37%)
		C2H2 Zn finger	482..502	CDD:275368	9/19 (47%)
		zf-H2C2_2	494..519	CDD:290200	13/26 (50%)
		C2H2 Zn finger	510..530	CDD:275368	8/22 (36%)
		C2H2 Zn finger	538..558	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910