DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF92

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_689839.1	Gene:	ZNF92 / 168374	HGNCID:	13168	Length:	586	Species:	Homo sapiens

Alignment Length:	329	Identity:	107/329 - (32%)
Similarity:	158/329 - (48%)	Gaps:	35/329 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 CSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSF 159
            |.:|.|.|...:.|.:|.:||:.|:|:||::|||::.::.||..| ...|...|.:.|.:|.|:|
Human   203 CEECGKAFNWSSTLTKHKIIHTGEKPYKCEECGKAFNRSSNLTKH-KIIHTGEKPYKCEECGKAF 266

  Fly   160 ALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLR 224
            .....|..|.|:|:.||||.|:.|.|.|.:...|.:|...|.:.  :.:.|.:|..:|...:.|:
Human   267 NRSSTLTKHKRIHTEEKPYKCEECGKAFNQFSILNKHKRIHMED--KPYKCEECGKAFRVFSILK 329

  Fly   225 VHMERHEQGMEHRCSICE---NQFANELALRAHINQEHHKLTQ-----FECEICHKMIEPDEDLA 281
            .|...|.....::|..|.   |||:         |...||:..     ::|:.|.|.......|.
Human   330 KHKIIHTGEKPYKCEECGKAFNQFS---------NLTKHKIIHTGEKPYKCDECGKAFNQSSTLT 385

  Fly   282 THMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGE 346
            .|.:.||..|.:.||.|...|.|.|....|..:||||:||:|..|.:.|:.||....|.|.|..:
Human   386 KHKRIHTGEKPYKCEECGKAFKQSSTLTEHKIIHTGEKPYKCEKCGKAFSWSSAFTKHKRNHMED 450

  Fly   347 KPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFK----------IKVELQSHVEH 401
            ||::|:.|..  |||..:.|..| |.||.::|||.||.|...|.          |..|.:|:  .
Human   451 KPYKCEECGK--AFSVFSTLTKH-KIIHTREKPYKCEECGKAFNQSSIFTKHKIIHTEGKSY--K 510

  Fly   402 CAKC 405
            |.||
Human   511 CEKC 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	50/154 (32%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	54/184 (29%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	6/24 (25%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	7/26 (27%)
ZNF92	NP_689839.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		zf-H2C2_2	216..240	CDD:290200	11/23 (48%)
		COG5048	227..579	CDD:227381	98/305 (32%)
		C2H2 Zn finger	231..251	CDD:275368	7/20 (35%)
		zf-H2C2_2	243..268	CDD:290200	9/25 (36%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		zf-H2C2_2	272..296	CDD:290200	12/23 (52%)
		C2H2 Zn finger	287..307	CDD:275368	6/19 (32%)
		zf-H2C2_2	300..322	CDD:290200	5/23 (22%)
		C2H2 Zn finger	315..335	CDD:275368	5/19 (26%)
		zf-H2C2_2	328..352	CDD:290200	5/23 (22%)
		C2H2 Zn finger	343..363	CDD:275368	8/28 (29%)
		zf-H2C2_2	355..380	CDD:290200	6/24 (25%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		zf-H2C2_2	384..408	CDD:290200	9/23 (39%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		zf-H2C2_2	412..435	CDD:290200	9/22 (41%)
		C2H2 Zn finger	427..447	CDD:275368	7/19 (37%)
		C2H2 Zn finger	455..475	CDD:275368	8/22 (36%)
		zf-H2C2_2	468..492	CDD:290200	12/24 (50%)
		C2H2 Zn finger	483..503	CDD:275368	4/19 (21%)
		C2H2 Zn finger	539..556	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000