DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF100

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_775802.2	Gene:	ZNF100 / 163227	HGNCID:	12880	Length:	542	Species:	Homo sapiens

Alignment Length:	498	Identity:	139/498 - (27%)
Similarity:	194/498 - (38%)	Gaps:	100/498 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RSVSKEDAVSLLTDSGISLSSPPAARESSPGPTLAIKRRKSSLASLRDACVDEEEDDGGEQDSKD 70
            |.|..|:..:|:..:||:|:.|........|......:|...:|.....|....:|...|||.|
Human    61 RKVMLENYRNLVFLAGIALTKPDLITCLEQGKEPWNIKRHEMVAKPPVICSHFPQDLWAEQDIK- 124

  Fly    71 DDYVQPQLKKSARKG----------------------------------------EP-------- 87
            |.:.:..|||..:.|                                        :|
Human   125 DSFQEAILKKYGKYGHDNLQLQKGCKSVDECKVHKEHDNKLNQCLITTQSNIFQCDPSAKVFHTF 189

  Fly    88 ----------VKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITT 142
                      .::|...|.:|.|.|.....|.:|...|..|..::||||||::.....|..| ..
Human   190 SNSNRHKIRHTRKKPFKCKKCEKSFCMLLHLTQHKRFHITENSYQCKDCGKAFNWFSTLTTH-RR 253

  Fly   143 AHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQ 207
            .|...|.:.|.:|.|:|.....|..|..:|:|||||.|:.|.|.|.|...|..|...|  |.::.
Human   254 IHTGEKPYKCEECGKAFNRSSHLTTHKIIHTGEKPYRCEECGKAFNRSSHLTTHKRIH--TGVKP 316

  Fly   208 FNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQ-----FEC 267
            :.||:|..:|:.:::|..|...|.....::|..|...|.....|..      ||:|.     ::|
Human   317 YKCTECGKAFNRSSHLTTHRIIHTGEKPYKCEECGKAFNQSSTLTT------HKITHAGEKPYKC 375

  Fly   268 EICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAH 332
            |.|.|.......|..|...||..|.:.||.|...|...|....|.|:||||:||:|..|.:.|..
Human   376 EECGKAFYRFSYLTKHKTSHTGEKFYKCEECGKGFNWSSALTKHKRIHTGEKPYKCEECGKAFNE 440

  Fly   333 SSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQS 397
            ||.|..|...||||||::|..|..  ||::.:.|..| |.||..:|||.||.|...|.....|..
Human   441 SSNLTTHKMIHTGEKPYKCDECGK--AFNRSSQLTAH-KMIHTGEKPYKCEECGKAFNRSSTLTK 502

  Fly   398 HV-----------EHCAKCPVDGDKPSGNQSEDAQILSVLRFN 429
            |.           |.|.|        ..|||     ||:::.|
Human   503 HKITHTGEKSYKWEECGK--------DFNQS-----LSLIKQN 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	50/158 (32%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	58/181 (32%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	4/21 (19%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF100	NP_775802.2	KRAB	35..96	CDD:214630	9/34 (26%)
		KRAB	35..74	CDD:279668	4/12 (33%)
		COG5048	150..534	CDD:227381	117/408 (29%)
		C2H2 Zn finger	207..227	CDD:275368	6/19 (32%)
		C2H2 Zn finger	235..255	CDD:275368	8/20 (40%)
		zf-H2C2_2	248..272	CDD:290200	8/24 (33%)
		C2H2 Zn finger	263..283	CDD:275368	6/19 (32%)
		zf-H2C2_2	275..300	CDD:290200	12/24 (50%)
		C2H2 Zn finger	291..311	CDD:275368	7/19 (37%)
		zf-H2C2_2	303..328	CDD:290200	8/26 (31%)
		C2H2 Zn finger	319..339	CDD:275368	6/19 (32%)
		zf-H2C2_2	331..356	CDD:290200	6/24 (25%)
		C2H2 Zn finger	347..367	CDD:275368	6/25 (24%)
		C2H2 Zn finger	375..395	CDD:275368	6/19 (32%)
		C2H2 Zn finger	403..423	CDD:275368	7/19 (37%)
		zf-H2C2_2	415..439	CDD:290200	10/23 (43%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		zf-H2C2_2	443..468	CDD:290200	12/26 (46%)
		C2H2 Zn finger	459..479	CDD:275368	7/22 (32%)
		zf-H2C2_2	472..496	CDD:290200	12/24 (50%)
		C2H2 Zn finger	487..507	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910