DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF780B

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_005258647.1	Gene:	ZNF780B / 163131	HGNCID:	33109	Length:	834	Species:	Homo sapiens

Alignment Length:	340	Identity:	109/340 - (32%)
Similarity:	163/340 - (47%)	Gaps:	36/340 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 GEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQ 149
            |:|.:     |.:|.|.|...|.|.||..||:.|:|.:||||||::.:..||..| .:.|...|.
Human   471 GKPFE-----CKECGKAFSLLTQLARHKNIHTGEKPFECKDCGKAFNRGSNLVQH-QSIHTGEKP 529

  Fly   150 FVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQ------------------- 195
            :.|.:|.|:|.|..:|..|.:.|:||||:.|..|.|.|.||..|.|
Human   530 YECKECGKAFRLHLQLSQHEKTHTGEKPFECKECGKFFRRGSNLNQHRSIHTGKKPFECKECGKA 594

  Fly   196 -----HMVSHHK--TSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRA 253
                 |::.|.|  |..:.|.|.:|..:||.:..|..|...|......:|..|...| |.::...
Human   595 FRLHMHLIRHQKFHTGEKPFECKECGKAFSLHTQLNHHKNIHTGEKPFKCKECGKSF-NRVSNLV 658

  Fly   254 HINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGE 318
            .....|..:..:||:.|.|......:|..|.:.|::.|..||:.|...|....|...|.|:||||
Human   659 QHQSIHAGVKPYECKECGKGFSRVSNLIQHQKTHSSAKPFVCKECRKTFRYHYQLTEHYRIHTGE 723

  Fly   319 RPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCE 383
            :|::|:.|.:.|...:.|..|...|||||||:|:.|..  ||::.::|. ..:.||..:|||.|:
Human   724 KPFECKECGKAFGLLTQLAQHQIIHTGEKPFKCKECGK--AFNRGSNLV-QPQSIHTGEKPYECK 785

  Fly   384 GCHDFFKIKVELQSH 398
            .|...|::.::|..|
Human   786 ECGKAFRLHLQLSLH 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	58/184 (32%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	13/24 (54%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	9/43 (21%)
		COG5048	<192..369	CDD:227381	56/202 (28%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	4/21 (19%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	5/19 (26%)
		C2H2 Zn finger	351..374	CDD:275368	5/22 (23%)
		C2H2 Zn finger	382..399	CDD:275368	5/17 (29%)
ZNF780B	XP_005258647.1	KRAB	6..67	CDD:214630
		KRAB	6..45	CDD:279668
		C2H2 Zn finger	168..188	CDD:275368
		zf-H2C2_2	180..203	CDD:290200
		COG5048	192..633	CDD:227381	55/167 (33%)
		C2H2 Zn finger	196..216	CDD:275368
		zf-H2C2_2	209..232	CDD:290200
		C2H2 Zn finger	224..244	CDD:275368
		C2H2 Zn finger	252..272	CDD:275368
		C2H2 Zn finger	280..300	CDD:275368
		C2H2 Zn finger	308..328	CDD:275368
		zf-H2C2_2	321..344	CDD:290200
		C2H2 Zn finger	336..356	CDD:275368
		zf-H2C2_2	349..372	CDD:290200
		C2H2 Zn finger	364..384	CDD:275368
		zf-H2C2_2	377..401	CDD:290200
		C2H2 Zn finger	392..412	CDD:275368
		C2H2 Zn finger	420..440	CDD:275368
		C2H2 Zn finger	448..468	CDD:275368
		C2H2 Zn finger	476..496	CDD:275368	8/19 (42%)
		zf-H2C2_2	489..513	CDD:290200	13/23 (57%)
		C2H2 Zn finger	504..524	CDD:275368	9/20 (45%)
		zf-H2C2_2	516..539	CDD:290200	8/23 (35%)
		C2H2 Zn finger	532..552	CDD:275368	7/19 (37%)
		zf-H2C2_2	545..569	CDD:290200	11/23 (48%)
		C2H2 Zn finger	560..580	CDD:275368	8/19 (42%)
		zf-H2C2_2	572..595	CDD:290200	2/22 (9%)
		C2H2 Zn finger	588..608	CDD:275368	3/19 (16%)
		zf-H2C2_2	600..624	CDD:290200	7/23 (30%)
		C2H2 Zn finger	616..636	CDD:275368	6/19 (32%)
		COG5048	624..>700	CDD:227381	17/76 (22%)
		zf-H2C2_2	629..653	CDD:290200	6/24 (25%)
		C2H2 Zn finger	644..664	CDD:275368	4/20 (20%)
		C2H2 Zn finger	672..692	CDD:275368	5/19 (26%)
		C2H2 Zn finger	700..720	CDD:275368	6/19 (32%)
		zf-H2C2_2	713..735	CDD:290200	9/21 (43%)
		C2H2 Zn finger	728..748	CDD:275368	5/19 (26%)
		zf-H2C2_2	741..765	CDD:290200	13/25 (52%)
		C2H2 Zn finger	756..776	CDD:275368	5/22 (23%)
		C2H2 Zn finger	784..803	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000