DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF383

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001332876.1	Gene:	ZNF383 / 163087	HGNCID:	18609	Length:	475	Species:	Homo sapiens

Alignment Length:	335	Identity:	106/335 - (31%)
Similarity:	162/335 - (48%)	Gaps:	42/335 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GEQDSKDDDYVQPQLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGK 128
            |:..|::..::|.|   ....||    |.:.|.:|.|.|...:.:.||:.||:.|:|.:||:|||
Human   176 GKAFSQNSQFIQHQ---RIHIGE----KSYECKECGKFFSCGSHVTRHLKIHTGEKPFECKECGK 233

  Fly   129 SYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQL 193
            ::..:..|..| ...|..:|.:.|.:|.|:|:....|..|.|:|:|||||.|.:|.|.|.:..||
Human   234 AFSCSSYLSQH-QRIHTGKKPYECKECGKAFSYCSNLIDHQRIHTGEKPYECKVCGKAFTKSSQL 297

  Fly   194 QQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQE 258
            .||...|  |..:.:.|.:|..:|:.::.|..|.                        |.|..::
Human   298 FQHARIH--TGEKPYECKECGKAFTQSSKLVQHQ------------------------RIHTGEK 336

  Fly   259 HHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQC 323
                 .:||:.|.|.......|..|.:.||..|.:.|:.|...|||.||...|.|:|.||:|::|
Human   337 -----PYECKECGKAFSSGSALTNHQRIHTGEKPYDCKECGKAFTQSSQLRQHQRIHAGEKPFEC 396

  Fly   324 RICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDF 388
            ..|.:.|..:|.|..|.|.||.|||:.|..|..  ||::.::|..|: :||..:|||.|:.|...
Human   397 LECGKAFTQNSQLFQHQRIHTDEKPYECNECGK--AFNKCSNLTRHL-RIHTGEKPYNCKECGKA 458

  Fly   389 FKIKVELQSH 398
            |....:|..|
Human   459 FSSGSDLIRH 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	48/158 (30%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		COG5048	<192..369	CDD:227381	52/176 (30%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	2/21 (10%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	9/19 (47%)
		zf-H2C2_2	309..332	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	5/17 (29%)
ZNF383	NP_001332876.1	KRAB	6..66	CDD:214630
		zf-C2H2	170..192	CDD:395048	4/18 (22%)
		C2H2 Zn finger	172..192	CDD:275368	4/18 (22%)
		zf-H2C2_2	187..209	CDD:404364	9/28 (32%)
		C2H2 Zn finger	200..220	CDD:275368	6/19 (32%)
		zf-H2C2_2	212..237	CDD:404364	11/24 (46%)
		C2H2 Zn finger	228..248	CDD:275368	7/20 (35%)
		COG5048	<231..475	CDD:227381	87/273 (32%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		C2H2 Zn finger	312..332	CDD:275368	6/43 (14%)
		C2H2 Zn finger	340..360	CDD:275368	5/19 (26%)
		C2H2 Zn finger	368..388	CDD:275368	9/19 (47%)
		C2H2 Zn finger	396..416	CDD:275368	7/19 (37%)
		C2H2 Zn finger	424..444	CDD:275368	6/22 (27%)
		C2H2 Zn finger	452..472	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910