DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF567

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001374688.1	Gene:	ZNF567 / 163081	HGNCID:	28696	Length:	670	Species:	Homo sapiens

Alignment Length:	393	Identity:	122/393 - (31%)
Similarity:	175/393 - (44%)	Gaps:	69/393 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 PQLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCG------------- 127
            |.:....|:...:::| |.|::|.|.|..|:.|..|..|||:|:|::|..||
Human   260 PSVYNKKRRATNIEKK-HTCNECGKSFCRKSVLILHQGIHSEEKPYQCHQCGNAFRRKSYLIDHQ 323

  Fly   128 ----------------------------------KSY-----RQAVNLKNHI---TTAHEHRKQF 150
                                              |||     |.|..||:|:   ...|...|.:
Human   324 RTHTGEKPFVCNECGKSFRLKTALTDHQRTHTGEKSYECLQCRNAFRLKSHLIRHQRTHTGEKPY 388

  Fly   151 VCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSA 215
            .|:.|.|||..|..|.||.|:|:|||||.|..|.|.|.:...|..|..:|  |..:.:.|.:|..
Human   389 ECNDCGKSFRQKTTLSLHQRIHTGEKPYICKECGKSFHQKANLTVHQRTH--TGEKPYICNECGK 451

  Fly   216 SFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDL 280
            |||....|.:|.:.|.:...:.||.|...|..:..|.|| .:.|.....:||..|.|.......|
Human   452 SFSQKTTLALHEKTHNEEKPYICSECGKSFRQKTTLVAH-QRTHTGEKSYECPHCGKAFRMKSYL 515

  Fly   281 ATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTG 345
            ..|.:.||..|.:.|..|...|:||:..|:|.|:||||:||.|..|.::|...:.|.:|.:.|||
Human   516 IDHHRTHTGEKPYECNECGKSFSQKTNLNLHQRIHTGEKPYVCNECGKSFRQKATLTVHQKIHTG 580

  Fly   346 EKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-HCAKCPVDG 409
            :|.:.|..|..  |||:.::|.:| ::.|..:|||.|..|...|:.|..|..|.. |      .|
Human   581 QKSYECPQCGK--AFSRKSYLIHH-QRTHTGEKPYKCSECGKCFRQKTNLIVHQRTH------TG 636

  Fly   410 DKP 412
            :||
Human   637 EKP 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	63/213 (30%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	13/76 (17%)
		C2H2 Zn finger	123..144	CDD:275368	11/75 (15%)
		C2H2 Zn finger	152..172	CDD:275368	10/19 (53%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	58/176 (33%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	7/21 (33%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	5/19 (26%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF567	NP_001374688.1	KRAB	6..89	CDD:214630
		C2H2 Zn finger	236..255	CDD:275368
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		COG5048	302..650	CDD:227381	107/350 (31%)
		C2H2 Zn finger	306..326	CDD:275368	3/19 (16%)
		C2H2 Zn finger	334..354	CDD:275368	0/19 (0%)
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		C2H2 Zn finger	390..410	CDD:275368	10/19 (53%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..494	CDD:275368	7/20 (35%)
		C2H2 Zn finger	502..522	CDD:275368	5/19 (26%)
		C2H2 Zn finger	530..550	CDD:275368	8/19 (42%)
		C2H2 Zn finger	558..578	CDD:275368	5/19 (26%)
		C2H2 Zn finger	586..606	CDD:275368	7/22 (32%)
		C2H2 Zn finger	614..634	CDD:275368	6/19 (32%)
		zf-C2H2	640..662	CDD:395048	122/393 (31%)
		C2H2 Zn finger	642..662	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910