DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF433

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_011526027.1	Gene:	ZNF433 / 163059	HGNCID:	20811	Length:	684	Species:	Homo sapiens

Alignment Length:	424	Identity:	124/424 - (29%)
Similarity:	185/424 - (43%)	Gaps:	66/424 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 TLAIKRRKSS----LASLRDACVDEEEDDGGEQDSKDDDYVQP-----------------QLKKS 81
            |..:|..:||    :.|...:......||.|.:..:..:|.|.                 |..:.
Human   109 TTGVKSCESSVYGEVGSAHSSLNRHIRDDTGHKAYEYQEYGQKPYKCKYCKKPFNCLSSVQTHER 173

  Fly    82 ARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEH 146
            |..|    ||.:||.:|.|.|...::||||.::|..:.|:|||.|||:.........|..| |..
Human   174 AHSG----RKLYVCEECGKTFISHSNLQRHRIMHRGDGPYKCKFCGKALMFLSLYLIHKRT-HTG 233

  Fly   147 RKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCT 211
            .|.:.|.||.|:|:....||:|.|.|:|||||.|:.|.|.|.....|..|..:|  |..:.:.|.
Human   234 EKPYQCKQCGKAFSHSSSLRIHERTHTGEKPYKCNECGKAFHSSTCLHAHKRTH--TGEKPYECK 296

  Fly   212 KCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHK--------------L 262
            :|..:||::.:.::|...|.....:.|..|...|....::|.|......|              |
Human   297 QCGKAFSSSHSFQIHERTHTGEKPYECKECGKAFKCPSSVRRHERTHSRKKPYECKHCGKVLSYL 361

  Fly   263 TQFE-------------CEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRM 314
            |.|:             |:||.|.......|.||.:.||..|.:.|..|...|...|.:..|.|.
Human   362 TSFQNHLGMHTGEISHKCKICGKAFYSPSSLQTHEKTHTGEKPYKCNQCGKAFNSSSSFRYHERT 426

  Fly   315 HTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKP 379
            ||||:||:|:.|.:.|..:|:|:.|.|.||||||:.|:.|..  .||..:..:.| :::|:::||
Human   427 HTGEKPYECKQCGKAFRSASLLQTHGRTHTGEKPYACKECGK--PFSNFSFFQIH-ERMHREEKP 488

  Fly   380 YMCEGCHDFFKIKVELQSH--------VEHCAKC 405
            |.|:|....|.:......|        ...|.:|
Human   489 YECKGYGKTFSLPSLFHRHERTHTGGKTYECKQC 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	55/158 (35%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	58/203 (29%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	5/22 (23%)
		C2H2 Zn finger	382..399	CDD:275368	4/24 (17%)
ZNF433	XP_011526027.1	KRAB	18..>60	CDD:214630
		KRAB	18..57	CDD:279668
		C2H2 Zn finger	145..175	CDD:275368	3/29 (10%)
		C2H2 Zn finger	183..203	CDD:275368	8/19 (42%)
		COG5048	208..614	CDD:227381	99/321 (31%)
		C2H2 Zn finger	211..231	CDD:275368	7/20 (35%)
		zf-H2C2_2	227..248	CDD:290200	9/21 (43%)
		C2H2 Zn finger	239..259	CDD:275368	9/19 (47%)
		zf-H2C2_2	251..276	CDD:290200	14/24 (58%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..304	CDD:290200	6/22 (27%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	307..332	CDD:290200	5/24 (21%)
		C2H2 Zn finger	323..343	CDD:275368	5/19 (26%)
		C2H2 Zn finger	351..371	CDD:275368	3/19 (16%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	9/24 (38%)
		C2H2 Zn finger	407..427	CDD:275368	6/19 (32%)
		zf-H2C2_2	419..444	CDD:290200	11/24 (46%)
		C2H2 Zn finger	435..455	CDD:275368	7/19 (37%)
		C2H2 Zn finger	463..483	CDD:275368	5/22 (23%)
		C2H2 Zn finger	491..511	CDD:275368	4/19 (21%)
		C2H2 Zn finger	519..539	CDD:275368	2/4 (50%)
		C2H2 Zn finger	547..567	CDD:275368
		C2H2 Zn finger	575..595	CDD:275368
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		zf-H2C2_2	643..668	CDD:290200
		C2H2 Zn finger	659..679	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000