DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF709

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_689814.1	Gene:	ZNF709 / 163051	HGNCID:	20629	Length:	641	Species:	Homo sapiens

Alignment Length:	320	Identity:	104/320 - (32%)
Similarity:	163/320 - (50%)	Gaps:	9/320 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SARKGEPVK--RKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTA 143
            |.||.|.:.  .|.:.|.:|.|.|......:|||::|:...|:|||:|||::....:.:.|..|
Human   322 SFRKHERIHTGEKPYDCKECGKAFISLPSYRRHMIMHTGNGPYKCKECGKAFDCPSSFQIHERT- 385

  Fly   144 HEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQF 208
            |...|.:.|.||.|:|:.....|:|.|.|:||||:.|..|.|.|:....::.|..:|  |..:.:
Human   386 HTGEKPYECKQCGKAFSCSSSFRMHERTHTGEKPHECKQCGKAFSCSSSVRIHERTH--TGEKPY 448

  Fly   209 NCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKM 273
            .|.:|..:||.:::.|:|...|.....:.|..|...|:...:.|.| .:.|.....:||:.|.|.
Human   449 ECKQCGKAFSCSSSFRMHERIHTGEKPYECKQCGKAFSFSSSFRMH-ERTHTGEKPYECKQCGKA 512

  Fly   274 IEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKL 338
            .........|.:.||..|.:.|:.|...|:..|...:|.|.||||:||:|:.|.:.|:.||.:::
Human   513 FSCSSSFRMHERTHTGEKPYECKQCGKAFSCSSSIRIHERTHTGEKPYECKQCGKAFSCSSSVRM 577

  Fly   339 HIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH 398
            |.|.|||.||:.|:.|:.  |||.....:.| ::.|..:|||.|:.|...||.....:.|
Human   578 HERTHTGVKPYECKQCDK--AFSCSRSFRIH-ERTHTGEKPYACQQCGKAFKCSRSFRIH 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	50/160 (31%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		COG5048	<192..369	CDD:227381	53/176 (30%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	4/19 (21%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	5/17 (29%)
ZNF709	NP_689814.1	KRAB	3..44	CDD:396083
		COG5048	77..551	CDD:227381	69/232 (30%)
		C2H2 Zn finger	104..124	CDD:275368
		C2H2 Zn finger	142..162	CDD:275368
		C2H2 Zn finger	170..190	CDD:275368
		C2H2 Zn finger	198..218	CDD:275368
		C2H2 Zn finger	226..246	CDD:275368
		C2H2 Zn finger	254..274	CDD:275368
		C2H2 Zn finger	282..302	CDD:275368
		C2H2 Zn finger	310..330	CDD:275368	4/7 (57%)
		C2H2 Zn finger	338..358	CDD:275368	7/19 (37%)
		C2H2 Zn finger	366..386	CDD:275368	7/20 (35%)
		C2H2 Zn finger	394..414	CDD:275368	8/19 (42%)
		C2H2 Zn finger	422..442	CDD:275368	5/19 (26%)
		C2H2 Zn finger	450..470	CDD:275368	6/19 (32%)
		C2H2 Zn finger	478..498	CDD:275368	5/20 (25%)
		C2H2 Zn finger	506..526	CDD:275368	4/19 (21%)
		C2H2 Zn finger	534..554	CDD:275368	6/19 (32%)
		zf-H2C2_2	550..571	CDD:404364	11/20 (55%)
		C2H2 Zn finger	562..582	CDD:275368	7/19 (37%)
		zf-H2C2_2	574..599	CDD:404364	11/26 (42%)
		C2H2 Zn finger	590..610	CDD:275368	6/22 (27%)
		C2H2 Zn finger	618..638	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910