DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF564

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_659413.1	Gene:	ZNF564 / 163050	HGNCID:	31106	Length:	553	Species:	Homo sapiens

Alignment Length:	337	Identity:	103/337 - (30%)
Similarity:	170/337 - (50%)	Gaps:	18/337 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 QLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHIT 141
            |:.:....||    |.:.|.:|:|.|......||||:.|:.:.|:||::|||::.:....:.|..
Human   213 QIHERTHTGE----KPYECQECAKAFISLPSFQRHMIRHTGDGPYKCQECGKAFDRPSLFRIHER 273

  Fly   142 TAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQ 206
            | |...|...|.||.|:|......:.||..|:|:.||.|.:|.:.|.....:::|..:|  |..:
Human   274 T-HTGEKPHECKQCGKAFISFTNFQSHMIRHTGDGPYKCKVCGRAFIFPSYVRKHERTH--TGEK 335

  Fly   207 QFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICH 271
            .:.|.||..:||:::|:|.|...|.....:.|..|...|.:..::|.|: .:|.....::|::|.
Human   336 PYECNKCGKTFSSSSNVRTHERTHTGEKPYECKECGKAFISLPSVRRHM-IKHTGDGPYKCQVCG 399

  Fly   272 KMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVL 336
            :..:.......|.:.||..|.:.|:||...|....:...||.:|||:.||:|::|.:.|...|.:
Human   400 RAFDCPSSFQIHERTHTGEKPYECQVCGKAFISLKRIRKHMILHTGDGPYKCQVCGKAFDCPSSV 464

  Fly   337 KLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE- 400
            :.|.|.||||||:.|:.|..  ||:..:.::.| ::.|..:|||.|:.|...|......|.|..
Human   465 RTHERTHTGEKPYECKECGK--AFNYASSIRIH-ERTHTGEKPYECKQCGKTFSYSSSFQRHERA 526

  Fly   401 HCAKCPVDGDKP 412
            |      :||||
Human   527 H------NGDKP 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	49/158 (31%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	9/23 (39%)
		C2H2 Zn finger	180..200	CDD:275368	4/19 (21%)
		COG5048	<192..369	CDD:227381	51/176 (29%)
		C2H2 Zn finger	210..230	CDD:275370	8/19 (42%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	3/19 (16%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	5/22 (23%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
ZNF564	NP_659413.1	KRAB	4..>46	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	78..97	CDD:275368
		COG5048	85..523	CDD:227381	97/320 (30%)
		C2H2 Zn finger	105..125	CDD:275368
		C2H2 Zn finger	143..163	CDD:275368
		zf-H2C2_2	155..180	CDD:290200
		C2H2 Zn finger	171..191	CDD:275368
		zf-H2C2_2	183..208	CDD:290200
		C2H2 Zn finger	199..219	CDD:275368	1/5 (20%)
		zf-H2C2_2	212..236	CDD:290200	8/26 (31%)
		C2H2 Zn finger	227..247	CDD:275368	8/19 (42%)
		zf-H2C2_2	239..264	CDD:290200	11/24 (46%)
		C2H2 Zn finger	255..275	CDD:275368	6/20 (30%)
		zf-H2C2_2	268..292	CDD:290200	9/24 (38%)
		zf-H2C2_2	295..318	CDD:290200	8/22 (36%)
		C2H2 Zn finger	311..331	CDD:275368	4/19 (21%)
		zf-H2C2_2	323..348	CDD:290200	7/26 (27%)
		C2H2 Zn finger	339..359	CDD:275368	8/19 (42%)
		zf-H2C2_2	351..376	CDD:290200	7/24 (29%)
		C2H2 Zn finger	367..387	CDD:275368	5/20 (25%)
		zf-H2C2_2	379..404	CDD:290200	5/25 (20%)
		C2H2 Zn finger	395..415	CDD:275368	3/19 (16%)
		zf-H2C2_2	407..432	CDD:290200	8/24 (33%)
		C2H2 Zn finger	423..443	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		zf-H2C2_2	463..488	CDD:290200	12/26 (46%)
		C2H2 Zn finger	479..499	CDD:275368	5/22 (23%)
		zf-H2C2_2	491..516	CDD:290200	8/25 (32%)
		C2H2 Zn finger	507..527	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910