DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF320

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001338702.1	Gene:	ZNF320 / 162967	HGNCID:	13842	Length:	509	Species:	Homo sapiens

Alignment Length:	422	Identity:	126/422 - (29%)
Similarity:	188/422 - (44%)	Gaps:	68/422 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LRDACVDEEEDDGGEQD----------SKDDDYVQPQLKKSARKGEPVKRKH------------- 92
            :.|.....:||:..:.:          |..|.|.|........||:...|.|
Human    94 IHDFVFQWQEDETNDHEAPMTEIKKLTSSTDRYDQRHAGNKPIKGQLESRFHLHLRRHRRIHTGE 158

  Fly    93 --HVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQC 155
              :.|.:|.|.|..|:.|:.|.:||:.|:|:|||.|.|:::...:|..| |..|...|.:.|::|
Human   159 KPYKCEECEKVFSCKSHLEIHRIIHTGEKPYKCKVCDKAFKHDSHLAKH-TRIHRGDKHYTCNEC 222

  Fly   156 PKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHK--TSIQQFNCTKCSASFS 218
            .|.|..|..|..|.|.|:|||||.|:.|.|.|::    ..|:|.||:  |..:.:.|.:|..:|:
Human   223 GKVFDQKATLACHHRSHTGEKPYKCNECGKTFSQ----TSHLVYHHRLHTGEKPYKCNECGKTFA 283

  Fly   219 TNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATH 283
            .|:.|.:|...|.....::|:.|...|.....|..| .:.|.....:.||.|.|:......|..|
Human   284 RNSVLVIHKAVHTAEKPYKCNECGKVFKQRATLAGH-RRVHTGEKPYRCEECDKVFSRKSHLERH 347

  Fly   284 MQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKP 348
            .:.||..|.:.|:||:..|...|:...|.|:|||||||.|..|.:.|:..:.|..|.:.|||||.
Human   348 RRIHTGEKPYKCKVCDKAFRSDSRLAEHQRVHTGERPYTCNECGKVFSTKAYLACHQKLHTGEKL 412

  Fly   349 FRCQLCEDEV---------------------------AFSQLAHLKNHMKKIHKQQKPYMCEGCH 386
            :.|:.| |:|                           ||:..:||..| ::||..||.|.|..|.
Human   413 YECEEC-DKVYIRKSHLERHRRIHTGEKPHKCGDCGKAFNSPSHLIRH-QRIHTGQKSYKCHQCG 475

  Fly   387 DFFKIKVELQSHV-----EHCAKCPVDGDKPS 413
            ..|.::..|..|.     ::|.||. :..|||
Human   476 KVFSLRSLLAEHQKIPFGDNCFKCN-EYSKPS 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	56/175 (32%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	59/205 (29%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	5/19 (26%)
		C2H2 Zn finger	351..374	CDD:275368	9/49 (18%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
ZNF320	NP_001338702.1	KRAB	7..48	CDD:396083
		SFP1	<25..216	CDD:227516	31/122 (25%)
		COG5048	147..483	CDD:227381	107/343 (31%)
		C2H2 Zn finger	163..183	CDD:275368	7/19 (37%)
		C2H2 Zn finger	191..211	CDD:275368	7/20 (35%)
		C2H2 Zn finger	219..239	CDD:275368	8/19 (42%)
		C2H2 Zn finger	247..267	CDD:275368	8/23 (35%)
		C2H2 Zn finger	275..295	CDD:275368	6/19 (32%)
		C2H2 Zn finger	303..323	CDD:275368	5/20 (25%)
		C2H2 Zn finger	331..351	CDD:275368	6/19 (32%)
		C2H2 Zn finger	359..379	CDD:275368	7/19 (37%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		C2H2 Zn finger	415..435	CDD:275368	4/20 (20%)
		C2H2 Zn finger	443..463	CDD:275368	5/20 (25%)
		C2H2 Zn finger	471..490	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910