DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF836

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001096127.1	Gene:	ZNF836 / 162962	HGNCID:	34333	Length:	936	Species:	Homo sapiens

Alignment Length:	408	Identity:	129/408 - (31%)
Similarity:	190/408 - (46%)	Gaps:	58/408 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 DDDYVQPQLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKS----- 129
            :::::|..|.....|.. ::.|.::|..|.|.|...:.|..|.::|:.|:|:||.:|||:
Human   196 ENEFLQLSLPTQLEKTH-IREKPYMCKGCGKAFRVSSSLINHQMVHTTEKPYKCNECGKAFHRGS 259

  Fly   130 -----------------------YRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRL 171
                                   :||..:|.|| ..:|...|.:.|::|.|||:....|.:|.|:
Human   260 LLTIHQIVHTRGKPYQCGVCGKIFRQNSDLVNH-RRSHTGEKPYKCNECGKSFSQSYNLAIHQRI 323

  Fly   172 HSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEH 236
            |:|||||.|:.|.|.|.:|..|..|.:.|  |..:.:.|..|...|..|:||..|...|.....:
Human   324 HTGEKPYKCNECGKTFKQGSCLTTHQIIH--TGEKPYQCDICGKVFRQNSNLVNHQRIHTGEKPY 386

  Fly   237 RCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTY 301
            :|:||...|:....|..| ...|.....::|:.|.|..:....|.||...||..|.:.|:||:..
Human   387 KCNICGKSFSQSSNLATH-QTVHSGNKPYKCDECGKTFKRSSSLTTHQIIHTGEKPYTCDVCDKV 450

  Fly   302 FTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHL 366
            |:|:||...|.|.||||:||:|..|.:.|:.:|.|..|.|.||||||::|..|..  ||.|.:.|
Human   451 FSQRSQLARHQRSHTGEKPYKCNECGKVFSQTSHLVGHRRIHTGEKPYKCDKCGK--AFKQGSLL 513

  Fly   367 KNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHV-----EHCAKCPVDGD--KPSGNQSEDAQILS 424
            ..| |.||.::|.|.|..|...|.....|..|:     |...||.|.|.  ..|||.|
Human   514 TRH-KIIHTREKRYQCGECGKVFSENSCLVRHLRIHTGEQPYKCNVCGKVFNYSGNLS------- 570

  Fly   425 VLRFNMAVVLKKISSAQK 442
                    :.|:|.:.:|
Human   571 --------IHKRIHTGEK 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	57/186 (31%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/52 (19%)
		C2H2 Zn finger	123..144	CDD:275368	9/48 (19%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	62/176 (35%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	9/19 (47%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
ZNF836	NP_001096127.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	220..240	CDD:275368	6/19 (32%)
		C2H2 Zn finger	248..268	CDD:275368	4/19 (21%)
		COG5048	272..648	CDD:227381	111/331 (34%)
		C2H2 Zn finger	276..296	CDD:275368	5/20 (25%)
		zf-H2C2_2	288..313	CDD:290200	10/25 (40%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		zf-H2C2_2	316..341	CDD:290200	13/24 (54%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		zf-H2C2_2	345..369	CDD:290200	7/25 (28%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		zf-H2C2_2	372..397	CDD:290200	8/24 (33%)
		C2H2 Zn finger	388..408	CDD:275368	6/20 (30%)
		zf-H2C2_2	400..425	CDD:290200	6/25 (24%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		zf-H2C2_2	428..453	CDD:290200	10/24 (42%)
		C2H2 Zn finger	444..464	CDD:275368	9/19 (47%)
		zf-H2C2_2	457..481	CDD:290200	11/23 (48%)
		C2H2 Zn finger	472..492	CDD:275368	7/19 (37%)
		zf-H2C2_2	484..509	CDD:290200	13/26 (50%)
		COG5048	496..904	CDD:227381	31/103 (30%)
		C2H2 Zn finger	500..520	CDD:275368	8/22 (36%)
		C2H2 Zn finger	528..548	CDD:275368	5/19 (26%)
		zf-H2C2_2	541..565	CDD:290200	7/23 (30%)
		C2H2 Zn finger	556..576	CDD:275368	8/34 (24%)
		zf-H2C2_2	568..593	CDD:290200	5/28 (18%)
		C2H2 Zn finger	584..604	CDD:275368
		zf-H2C2_2	597..620	CDD:290200
		C2H2 Zn finger	612..632	CDD:275368
		zf-H2C2_2	624..649	CDD:290200
		C2H2 Zn finger	640..660	CDD:275368
		zf-H2C2_2	653..677	CDD:290200
		C2H2 Zn finger	668..688	CDD:275368
		C2H2 Zn finger	696..714	CDD:275370
		C2H2 Zn finger	724..744	CDD:275368
		C2H2 Zn finger	752..772	CDD:275368
		zf-H2C2_2	764..789	CDD:290200
		C2H2 Zn finger	780..800	CDD:275368
		zf-H2C2_2	793..815	CDD:290200
		C2H2 Zn finger	808..828	CDD:275368
		zf-H2C2_2	821..843	CDD:290200
		C2H2 Zn finger	836..856	CDD:275368
		zf-H2C2_2	849..873	CDD:290200
		C2H2 Zn finger	864..884	CDD:275368
		zf-H2C2_2	877..899	CDD:290200
		C2H2 Zn finger	892..912	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910