DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11247 and ZNF782

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001001662.1	Gene:	ZNF782 / 158431	HGNCID:	33110	Length:	699	Species:	Homo sapiens

Alignment Length:	340	Identity:	118/340 - (34%)
Similarity:	175/340 - (51%)	Gaps:	14/340 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 EEDDGGEQDSKDDDYVQPQLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKC 123
            |.::.|:..|.:...:.||   .:..||    |.:.|.:|.|.|..|:.|::|...|:.|:|:||
Human   367 EYNECGKSCSMNSHLIWPQ---KSHTGE----KPYECPECGKAFSEKSRLRKHQRTHTGEKPYKC 424

  Fly   124 KDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFA 188
            ..|.|::.....|:.|..| |...|.|.|.:|.|||..|..|.:|.|.|:||||:.|:.|.|.|:
Human   425 DGCDKAFSAKSGLRIHQRT-HTGEKPFECHECGKSFNYKSILIVHQRTHTGEKPFECNECGKSFS 488

  Fly   189 RGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRA 253
            ....|:.|..:|  |..:.:.|.:|..:|...:.||.|...|.....::|:.|...|..:..||.
Human   489 HMSGLRNHRRTH--TGERPYKCDECGKAFKLKSGLRKHHRTHTGEKPYKCNQCGKAFGQKSQLRG 551

  Fly   254 HINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGE 318
            | ::.|.....::|..|.:......:|..|.:.||..|.:.||.|...|.|||....|.|.||||
Human   552 H-HRIHTGEKPYKCNHCGEAFSQKSNLRVHHRTHTGEKPYQCEECGKTFRQKSNLRGHQRTHTGE 615

  Fly   319 RPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCE 383
            :||:|..|.:.|:..|||:.|.|.||||||:.|..|.:  ||||.::|:.| ::.|..:|||.|:
Human   616 KPYECNECGKAFSEKSVLRKHQRTHTGEKPYNCNQCGE--AFSQKSNLRVH-QRTHTGEKPYKCD 677

  Fly   384 GCHDFFKIKVELQSH 398
            .|...|..|..|:.|
Human   678 KCGRTFSQKSSLREH 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	53/158 (34%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	9/24 (38%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	61/176 (35%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	4/19 (21%)
		C2H2 Zn finger	295..315	CDD:275368	9/19 (47%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	6/17 (35%)
ZNF782	NP_001001662.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..95
		C2H2 Zn finger	291..307	CDD:275368
		C2H2 Zn finger	314..332	CDD:275368
		C2H2 Zn finger	343..360	CDD:275368
		C2H2 Zn finger	369..388	CDD:275368	4/21 (19%)
		COG5048	392..697	CDD:227381	111/308 (36%)
		C2H2 Zn finger	396..416	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..432	CDD:290200	9/22 (41%)
		C2H2 Zn finger	424..444	CDD:275368	6/20 (30%)
		zf-H2C2_2	437..461	CDD:290200	11/24 (46%)
		C2H2 Zn finger	452..472	CDD:275368	9/19 (47%)
		zf-H2C2_2	465..489	CDD:290200	12/23 (52%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		zf-H2C2_2	493..516	CDD:290200	6/24 (25%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		zf-H2C2_2	521..543	CDD:290200	6/21 (29%)
		C2H2 Zn finger	536..556	CDD:275368	6/20 (30%)
		zf-H2C2_2	549..573	CDD:290200	6/24 (25%)
		C2H2 Zn finger	564..584	CDD:275368	4/19 (21%)
		zf-H2C2_2	576..601	CDD:290200	9/24 (38%)
		C2H2 Zn finger	592..612	CDD:275368	9/19 (47%)
		zf-H2C2_2	604..628	CDD:290200	10/23 (43%)
		C2H2 Zn finger	620..640	CDD:275368	8/19 (42%)
		zf-H2C2_2	633..657	CDD:290200	13/25 (52%)
		C2H2 Zn finger	648..668	CDD:275368	8/22 (36%)
		zf-H2C2_2	660..685	CDD:290200	9/25 (36%)
		C2H2 Zn finger	676..696	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910