DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF595

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_872330.1	Gene:	ZNF595 / 152687	HGNCID:	27196	Length:	648	Species:	Homo sapiens

Alignment Length:	393	Identity:	125/393 - (31%)
Similarity:	174/393 - (44%)	Gaps:	59/393 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KHHV---------CSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEH 146
            ||.:         |::|.:.| ..:.|.:|..||:.|:|:||:.|||::.::.:|..| ...|..
Human   162 KHKIRHTGEKPFKCTECGRSF-YMSHLTQHTGIHAGEKPYKCEKCGKAFNRSTSLSKH-KRIHTG 224

  Fly   147 RKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCT 211
            .|.:.|.:|.|:|.....|..|.::|:|||||.|:.|.|.|.|...|.:|...|  |..:.:.|.
Human   225 EKPYTCEECGKAFRRSTVLNEHKKIHTGEKPYKCEECGKAFTRSTTLNEHKKIH--TGEKPYKCK 287

  Fly   212 KCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEP 276
            :|..:|..:.:|..|...|.....::|..|...|....:|..|.| .|.....:.||.|.|....
Human   288 ECGKAFRWSTSLNEHKNIHTGEKPYKCKECGKAFRQSRSLNEHKN-IHTGEKPYTCEKCGKAFNQ 351

  Fly   277 DEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIR 341
            ...|..|...|:..|.:.||.|...||..|..|.|.|:||||:||.|..|.:.|..||.|..|.|
Human   352 SSSLIIHRSIHSEQKLYKCEECGKAFTWSSSLNKHKRIHTGEKPYTCEECGKAFYRSSHLAKHKR 416

  Fly   342 KHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH-------- 398
            .||||||:.|:.|..  ||:|.:.|..| |:||..||||.||.|...|.....|..|
Human   417 IHTGEKPYTCEECGK--AFNQSSTLILH-KRIHSGQKPYKCEECGKAFTRSTTLNEHKKIHTGEK 478

  Fly   399 ---VEHCAKCPV------------DGDKP--------SGNQSEDAQILSVLRFNMAVVLKKISSA 440
               .|.|.|..:            .|:||        :.|||..           .::.:.|.|.
Human   479 PYKCEECGKAFIWSASLNEHKNIHTGEKPYKCKECGKAFNQSSG-----------LIIHRSIHSE 532

  Fly   441 QKL 443
            |||
Human   533 QKL 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	50/164 (30%)
		C2H2 Zn finger	95..115	CDD:275368	5/19 (26%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	60/176 (34%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	9/19 (47%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	6/27 (22%)
ZNF595	NP_872330.1	KRAB	4..64	CDD:214630
		C2H2 Zn finger	147..167	CDD:275368	2/4 (50%)
		C2H2 Zn finger	175..194	CDD:275368	5/19 (26%)
		COG5048	198..599	CDD:227381	115/356 (32%)
		C2H2 Zn finger	202..222	CDD:275368	6/20 (30%)
		C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	6/20 (30%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		C2H2 Zn finger	370..390	CDD:275368	9/19 (47%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..446	CDD:275368	8/22 (36%)
		C2H2 Zn finger	454..474	CDD:275368	6/19 (32%)
		C2H2 Zn finger	482..502	CDD:275368	3/19 (16%)
		C2H2 Zn finger	510..530	CDD:275368	3/30 (10%)
		C2H2 Zn finger	538..558	CDD:275368
		C2H2 Zn finger	566..586	CDD:275368
		C2H2 Zn finger	594..614	CDD:275368
		C2H2 Zn finger	622..642	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910