DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF681

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_612143.2	Gene:	ZNF681 / 148213	HGNCID:	26457	Length:	645	Species:	Homo sapiens

Alignment Length:	313	Identity:	113/313 - (36%)
Similarity:	164/313 - (52%)	Gaps:	13/313 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCS 153
            :.|.:...:|.|.|...:.|.||.:||:.|:|:||::|||::.|:.:|..| ...|...|.:.|.
Human   306 REKLNEYKECGKAFNQSSHLTRHKIIHTGEKPYKCEECGKAFNQSSHLTRH-KIIHTGEKPYRCE 369

  Fly   154 QCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFS 218
            :|.|:|.....|..|..:|:|||||.|:.|.|.|.:...|.:|...|  |..:.:.|.||..:.:
Human   370 ECGKAFRQSSHLTTHKIIHTGEKPYKCEECGKAFNKSSHLTRHKSIH--TGEKPYQCEKCGKASN 432

  Fly   219 TNANLRVHMERHEQGMEHRCSICE---NQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDL 280
            .::||..|...|.:...::|..|.   |||:|   |..| .:.|.....::||.|.|.......|
Human   433 QSSNLTEHKNIHTEEKPYKCEECGKAFNQFSN---LTTH-KRIHTGEKPYKCEECGKAFNQSSIL 493

  Fly   281 ATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTG 345
            .||.:.||..|::.||.|...|.:.|:...|.::||||:||.|..|.:.|.|||.|..|...|||
Human   494 TTHKRIHTGEKSYKCEECGKAFYRSSKLTEHKKIHTGEKPYTCEECGKAFNHSSHLATHKVIHTG 558

  Fly   346 EKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH 398
            |||::|:.|..  ||:|.:||..| |:||..:|||.||.|...|.....|..|
Human   559 EKPYQCEECGK--AFNQSSHLTRH-KRIHTGEKPYQCEKCGKAFNQSSNLTGH 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	53/160 (33%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	63/179 (35%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	8/24 (33%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	9/22 (41%)
		C2H2 Zn finger	382..399	CDD:275368	6/17 (35%)
ZNF681	NP_612143.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	144..164	CDD:275368
		C2H2 Zn finger	176..192	CDD:275368
		COG5048	198..610	CDD:227381	113/313 (36%)
		C2H2 Zn finger	200..220	CDD:275368
		C2H2 Zn finger	285..304	CDD:275368
		C2H2 Zn finger	313..332	CDD:275368	6/18 (33%)
		zf-H2C2_2	324..349	CDD:290200	12/24 (50%)
		C2H2 Zn finger	340..360	CDD:275368	7/20 (35%)
		zf-H2C2_2	352..377	CDD:290200	8/25 (32%)
		C2H2 Zn finger	368..388	CDD:275368	6/19 (32%)
		zf-H2C2_2	380..404	CDD:290200	11/23 (48%)
		C2H2 Zn finger	396..416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	424..444	CDD:275368	6/19 (32%)
		zf-H2C2_2	436..461	CDD:290200	6/24 (25%)
		C2H2 Zn finger	452..472	CDD:275368	8/23 (35%)
		zf-H2C2_2	464..489	CDD:290200	8/28 (29%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		zf-H2C2_2	493..517	CDD:290200	10/23 (43%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		zf-H2C2_2	521..545	CDD:290200	10/23 (43%)
		C2H2 Zn finger	536..556	CDD:275368	8/19 (42%)
		zf-H2C2_2	548..573	CDD:290200	12/26 (46%)
		C2H2 Zn finger	564..584	CDD:275368	9/22 (41%)
		zf-H2C2_2	576..601	CDD:290200	13/25 (52%)
		C2H2 Zn finger	592..612	CDD:275368	6/17 (35%)
		C2H2 Zn finger	620..638	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	626..645
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000