DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF98

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001092096.1	Gene:	ZNF98 / 148198	HGNCID:	13174	Length:	572	Species:	Homo sapiens

Alignment Length:	313	Identity:	110/313 - (35%)
Similarity:	159/313 - (50%)	Gaps:	15/313 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 RKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQ 154
            :|.:.|.:|.|.|...:.|..|.:||:.::|:||::|||::.|:.||..| ...|...|.:.|.:
Human   235 KKPYKCEECGKAFNRLSHLTTHKIIHTGKKPYKCEECGKAFNQSANLTTH-KRIHTGEKPYKCEE 298

  Fly   155 CPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFST 219
            |.::|:....|..|..:|:|||||.|:.|.|.|::...|..|.:.|  |..:.:.|.:|..:||.
Human   299 CGRAFSQSSTLTAHKIIHAGEKPYKCEECGKAFSQSSTLTTHKIIH--TGEKFYKCEECGKAFSR 361

  Fly   220 NANLRVHMERHEQGMEHRCSICENQFANELAL----RAHINQEHHKLTQFECEICHKMIEPDEDL 280
            .::|..|...|.....::|..|...|.....|    |.|..::.:|     ||:|.|.......|
Human   362 LSHLTTHKRIHSGEKPYKCEECGKAFKQSSTLTTHKRIHAGEKFYK-----CEVCSKAFSRFSHL 421

  Fly   281 ATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTG 345
            .||.:.||..|.:.||.|...|...||...|..:||||:||:|..|.:.|..||.|..|...|||
Human   422 TTHKRIHTGEKPYKCEECGKAFNLSSQLTTHKIIHTGEKPYKCEECGKAFNQSSTLSKHKVIHTG 486

  Fly   346 EKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH 398
            |||::|:.|..  ||:|.:||..| |.||..:|||.||.|...|.....|..|
Human   487 EKPYKCEECGK--AFNQSSHLTTH-KMIHTGEKPYKCEECGKAFNNSSILNRH 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	50/156 (32%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	5/19 (26%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	61/180 (34%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/25 (24%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	9/22 (41%)
		C2H2 Zn finger	382..399	CDD:275368	6/17 (35%)
ZNF98	NP_001092096.1	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		COG5048	179..563	CDD:227381	110/313 (35%)
		C2H2 Zn finger	184..204	CDD:275368
		zf-H2C2_2	196..220	CDD:290200
		C2H2 Zn finger	212..232	CDD:275368
		zf-H2C2_2	224..249	CDD:290200	5/13 (38%)
		C2H2 Zn finger	240..260	CDD:275368	6/19 (32%)
		zf-H2C2_2	252..277	CDD:290200	10/24 (42%)
		C2H2 Zn finger	268..288	CDD:275368	8/20 (40%)
		zf-H2C2_2	280..305	CDD:290200	8/25 (32%)
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	7/25 (28%)
		zf-C2H2	350..372	CDD:278523	6/21 (29%)
		C2H2 Zn finger	352..372	CDD:275368	6/19 (32%)
		zf-H2C2_2	364..389	CDD:290200	6/24 (25%)
		C2H2 Zn finger	380..400	CDD:275368	5/19 (26%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		zf-H2C2_2	420..444	CDD:290200	9/23 (39%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		zf-H2C2_2	449..473	CDD:290200	10/23 (43%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		zf-H2C2_2	477..501	CDD:290200	12/25 (48%)
		C2H2 Zn finger	492..512	CDD:275368	9/22 (41%)
		zf-H2C2_2	504..529	CDD:290200	13/25 (52%)
		C2H2 Zn finger	520..540	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000