DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF599

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001007249.1	Gene:	ZNF599 / 148103	HGNCID:	26408	Length:	588	Species:	Homo sapiens

Alignment Length:	385	Identity:	114/385 - (29%)
Similarity:	174/385 - (45%)	Gaps:	54/385 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 DSKDDDYVQPQLKKSARKGEPVKR--------KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKC 123
            |::::.|...:..|...|...:.|        |.:.|::|.|......|:.|||.:|:.|:|:||
Human   193 DARNNPYTCTECGKGFSKKWALVRHQQIHAGVKPYECNECGKACRYMADVIRHMRLHTGEKPYKC 257

  Fly   124 KDCGKSYRQAVNLKNH--ITT-------------------------AHEHRKQFVCSQCPKSFAL 161
            .:|||::::..:|..|  |.|                         .|...|.|:|.:|.|:|..
Human   258 IECGKAFKRRFHLTEHQRIHTGDKPYECKECGKAFTHRSSFIQHNMTHTREKPFLCKECGKAFYY 322

  Fly   162 KERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVH 226
            ......|||:|:|:|.|.|..|.|.|.......||.|:|  |..:.|.|.:|..:|..|::...|
Human   323 SSSFAQHMRIHTGKKLYECGECGKAFTHRSTFIQHNVTH--TGEKPFLCKECGKTFCLNSSFTQH 385

  Fly   227 MERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVK 291
            |..|.....:.|..|...|.:......| .:.|.....|||:.|.|.......|..||:.||..|
Human   386 MRIHTGEKPYECGECGKAFTHRSTFIRH-KRTHTGEKPFECKECGKAFCDSSSLIQHMRIHTGEK 449

  Fly   292 THVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCED 356
            .:.|..|...||..|.:..|.|.|:|::|.:|:.|.:.|.:||....|:|.||||||:.|:.|..
Human   450 PYECSECGKAFTHHSVFIRHNRTHSGQKPLECKECAKAFYYSSSFTRHMRIHTGEKPYVCRECGK 514

  Fly   357 EVAFSQLAHLKNHMKKIHKQQKPYMCEGCH----DFFKIKVELQSHVEHCAKCPVDGDKP 412
              ||:|.|:...| .:||..:||:.|:.|.    |.|.:...:::|.         |:||
Human   515 --AFTQPANFVRH-NRIHTGEKPFECKECEKAFCDNFALTQHMRTHT---------GEKP 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	55/193 (28%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	8/47 (17%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	58/176 (33%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	4/21 (19%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	8/22 (36%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	4/20 (20%)
ZNF599	NP_001007249.1	KRAB	9..69	CDD:214630
		KRAB	9..48	CDD:279668
		C2H2 Zn finger	201..221	CDD:275368	3/19 (16%)
		C2H2 Zn finger	229..249	CDD:275368	7/19 (37%)
		zf-H2C2_2	244..266	CDD:290200	11/21 (52%)
		COG5048	253..>580	CDD:227381	99/325 (30%)
		C2H2 Zn finger	257..277	CDD:275368	6/19 (32%)
		zf-H2C2_2	269..294	CDD:290200	4/24 (17%)
		C2H2 Zn finger	285..305	CDD:275368	0/19 (0%)
		C2H2 Zn finger	313..333	CDD:275368	7/19 (37%)
		zf-H2C2_2	325..350	CDD:290200	11/24 (46%)
		C2H2 Zn finger	341..361	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		zf-H2C2_2	381..406	CDD:290200	6/24 (25%)
		C2H2 Zn finger	397..417	CDD:275368	4/20 (20%)
		zf-H2C2_2	412..432	CDD:290200	7/20 (35%)
		C2H2 Zn finger	425..445	CDD:275368	6/19 (32%)
		zf-H2C2_2	437..462	CDD:290200	9/24 (38%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
		zf-H2C2_2	493..518	CDD:290200	12/26 (46%)
		C2H2 Zn finger	509..529	CDD:275368	7/22 (32%)
		zf-H2C2_2	521..544	CDD:290200	7/23 (30%)
		C2H2 Zn finger	537..557	CDD:275368	4/19 (21%)
		zf-H2C2_2	549..574	CDD:290200	4/23 (17%)
		C2H2 Zn finger	565..585	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000