DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF534

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001137411.1	Gene:	ZNF534 / 147658	HGNCID:	26337	Length:	674	Species:	Homo sapiens

Alignment Length:	327	Identity:	106/327 - (32%)
Similarity:	160/327 - (48%)	Gaps:	23/327 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQC 155
            |.:.||:|.|.|...:.|..|::||:.|:|:.||:|||.:|...:|..| .|.|...:.:.|::|
Human   309 KPYKCSECGKAFSVCSSLTAHLVIHTGEKPYDCKECGKVFRHKSSLTTH-QTVHTGERPYKCNEC 372

  Fly   156 PKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTN 220
            .|.|:....|..|.::|:|||||.|:.|.|.|....:|.:|...|  |..:::.|.:|..:|.|.
Human   373 GKGFSRIAFLARHRKVHTGEKPYKCNECGKVFIGNSRLARHRKIH--TGGRRYKCNECGKAFRTC 435

  Fly   221 ANLRVHMERHEQGMEHRCSICENQFANELAL----RAHINQEHHKLTQFECEICHKMIEPDEDLA 281
            ::|..|:..|.....:.|..|...|.::.:|    |.|..::.:|     |..|.|:...:.:|.
Human   436 SDLTAHLLIHTGEKPYECIDCGKVFRHKSSLTYHCRIHTGEKPYK-----CNECGKVFSQNSNLQ 495

  Fly   282 THMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGE 346
            .|.:.||..|.:.|..|...|.|.|....|..:||||:||.|..|.:.|..:|.|..|...||||
Human   496 RHRKIHTGEKLYKCNECGKVFRQNSHLAQHRDIHTGEKPYSCNECGKVFRRNSHLVRHRNVHTGE 560

  Fly   347 KPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH--------VEHCA 403
            ||:.|..|..  .||:.:||..| :.||..:||:.|..|...|.....|..|        :..|.
Human   561 KPYSCNECGK--VFSRNSHLARH-RNIHTGEKPHSCNECGKVFSRNSHLARHRKIHTGEKLYKCN 622

  Fly   404 KC 405
            :|
Human   623 EC 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	52/155 (34%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	56/180 (31%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/25 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/24 (21%)
ZNF534	NP_001137411.1	KRAB	8..81	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	201..221	CDD:275368
		COG5048	211..609	CDD:227381	103/310 (33%)
		C2H2 Zn finger	229..249	CDD:275368
		zf-H2C2_2	241..266	CDD:290200
		C2H2 Zn finger	258..277	CDD:275368
		C2H2 Zn finger	286..305	CDD:275368
		zf-H2C2_2	297..321	CDD:290200	5/11 (45%)
		C2H2 Zn finger	313..333	CDD:275368	7/19 (37%)
		C2H2 Zn finger	341..361	CDD:275368	9/20 (45%)
		zf-H2C2_2	353..378	CDD:290200	8/25 (32%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		zf-H2C2_2	382..404	CDD:290200	11/21 (52%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		C2H2 Zn finger	425..445	CDD:275368	6/19 (32%)
		C2H2 Zn finger	453..473	CDD:275368	5/19 (26%)
		zf-H2C2_2	465..490	CDD:290200	7/29 (24%)
		C2H2 Zn finger	481..501	CDD:275368	5/19 (26%)
		zf-H2C2_2	493..518	CDD:290200	8/24 (33%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		zf-H2C2_2	521..546	CDD:290200	10/24 (42%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		zf-H2C2_2	549..574	CDD:290200	11/26 (42%)
		C2H2 Zn finger	565..585	CDD:275368	7/22 (32%)
		zf-H2C2_2	577..602	CDD:290200	10/25 (40%)
		C2H2 Zn finger	593..613	CDD:275368	5/19 (26%)
		zf-H2C2_2	605..630	CDD:290200	4/20 (20%)
		C2H2 Zn finger	621..641	CDD:275368	2/4 (50%)
		C2H2 Zn finger	649..669	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910