DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11247 and ZNF57

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_775751.1	Gene:	ZNF57 / 126295	HGNCID:	13125	Length:	555	Species:	Homo sapiens

Alignment Length:	412	Identity:	119/412 - (28%)
Similarity:	186/412 - (45%)	Gaps:	66/412 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RESSPGPTLAIKRRKSSLASLRDACV-DEEEDDGGEQDSKDDDYVQPQLKKSARKGE----PVKR 90
            |::.||            ...:.||: .......|..|:::..|      |....|:    |...
Human   165 RKAPPG------------EECKQACICPSHLHSHGRTDTEEKPY------KCQACGQTFQHPRYL 211

  Fly    91 KHHV----------CSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITT--- 142
            .|||          |.||...|.|.....||:..|:.:||:||::||:::......:.|:||
Human   212 SHHVKTHTAEKTYKCEQCRMAFNGFASFTRHVRTHTKDRPYKCQECGRAFIYPSTFQRHMTTHTG 276

  Fly   143 ------------------------AHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLC 183
                                    .|...|.:.|.||.|:|:..|.||:|||:|:|:|.|.|:.|
Human   277 EKPYKCQHCGKAFTYPQAFQRHEKTHTGEKPYECKQCGKTFSWSETLRVHMRIHTGDKLYKCEHC 341

  Fly   184 DKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANE 248
            .|.|......|.|:.:|  |..:.:.|.:|..:|:.::..|.|:..|.|...::|..|...|.:.
Human   342 GKAFTSSRSFQGHLRTH--TGEKPYECKQCGKAFTWSSTFREHVRIHTQEQLYKCEQCGKAFTSS 404

  Fly   249 LALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMR 313
            .:.|.|: :.|.....:||:.|.|..........|::.||..:.|.||.|...||....:..|:|
Human   405 RSFRGHL-RTHTGEKPYECKQCGKTFTWSSTFREHVRIHTQEQLHKCEHCGKAFTSSRAFQGHLR 468

  Fly   314 MHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQK 378
            |||||:||:|:.|.:||..||.|..|:|.||||||.:|:.|  .::|...:..:||: ::|..||
Human   469 MHTGEKPYECKQCGKTFTWSSTLHNHVRMHTGEKPHKCKQC--GMSFKWHSSFRNHL-RMHTGQK 530

  Fly   379 PYMCEGCHDFFKIKVELQSHVE 400
            .:.|:.....|..:|.|....|
Human   531 SHECQSYSKAFSCQVILSKTSE 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	55/195 (28%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	9/24 (38%)
		C2H2 Zn finger	123..144	CDD:275368	6/47 (13%)
		C2H2 Zn finger	152..172	CDD:275368	11/19 (58%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	57/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	4/19 (21%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	13/22 (59%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		C2H2 Zn finger	351..374	CDD:275368	5/22 (23%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
ZNF57	NP_775751.1	KRAB	4..>44	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	118..134	CDD:275368
		COG5048	138..546	CDD:227381	116/404 (29%)
		C2H2 Zn finger	142..162	CDD:275368
		C2H2 Zn finger	171..190	CDD:275368	3/18 (17%)
		C2H2 Zn finger	198..218	CDD:275368	5/19 (26%)
		C2H2 Zn finger	226..246	CDD:275368	7/19 (37%)
		C2H2 Zn finger	254..274	CDD:275368	5/19 (26%)
		zf-H2C2_2	267..291	CDD:290200	3/23 (13%)
		C2H2 Zn finger	282..302	CDD:275368	0/19 (0%)
		zf-H2C2_2	294..318	CDD:290200	6/23 (26%)
		C2H2 Zn finger	310..330	CDD:275368	11/19 (58%)
		zf-H2C2_2	323..347	CDD:290200	13/23 (57%)
		C2H2 Zn finger	338..358	CDD:275368	6/19 (32%)
		zf-H2C2_2	350..374	CDD:290200	6/25 (24%)
		C2H2 Zn finger	366..386	CDD:275368	5/19 (26%)
		C2H2 Zn finger	394..414	CDD:275368	5/20 (25%)
		zf-H2C2_2	406..430	CDD:290200	7/24 (29%)
		C2H2 Zn finger	422..442	CDD:275368	4/19 (21%)
		C2H2 Zn finger	450..470	CDD:275368	7/19 (37%)
		zf-H2C2_2	466..486	CDD:290200	12/19 (63%)
		C2H2 Zn finger	478..498	CDD:275368	9/19 (47%)
		C2H2 Zn finger	506..526	CDD:275368	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910