DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF573

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001166161.1	Gene:	ZNF573 / 126231	HGNCID:	26420	Length:	665	Species:	Homo sapiens

Alignment Length:	365	Identity:	114/365 - (31%)
Similarity:	169/365 - (46%)	Gaps:	47/365 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 QLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNH-- 139
            ::.:....||    |.:.|.:|.|.|..:::|..|...|:||:|:.|:.|||::|:...|..|
Human   262 RIHQRVHTGE----KPYKCKECGKTFSRRSNLVEHGQFHTDEKPYICEKCGKAFRRGHQLTVHQR 322

  Fly   140 ----------------ITTA---------HEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYP 179
                            .|||         |:..|.:.|.:|.|:|.|...|..|..:|:|||.:.
Human   323 VHTGKKPYECKECGKGYTTASYFLLHQRIHKGGKPYECKECKKTFTLYRNLTRHQNIHTGEKLFE 387

  Fly   180 CDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEH-RCSICEN 243
            |..|.|.:..|.:|.||..:|  |..:.:.|.:|..:||....|:.|.:.| .||:| .|..|:.
Human   388 CKQCGKTYTTGSKLFQHQKTH--TGEKPYECKECGKAFSLYGYLKQHQKIH-TGMKHFECKECKK 449

  Fly   244 QFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQY 308
            .|.....|..|.| .|.....|||:.|.|......:|..|.:.||..|.:.|:.|...|:.....
Human   450 TFTLYRNLTRHQN-IHTGKKLFECQECGKAYSTGSNLIQHRKTHTGEKPYKCKECGKTFSLHGYL 513

  Fly   309 NVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKI 373
            |.|.::|||.:||:|::|.:||.....|.||...||.||||.|:.|..  .|.:.:||..| :.|
Human   514 NQHQKIHTGMKPYECKVCRKTFTFYRNLTLHQSIHTDEKPFECKECGK--TFRRSSHLTAH-QSI 575

  Fly   374 HKQQKPYMCEGCHDFFKIKVELQSHVE--------HCAKC 405
            |..:|||.|:.|...||:...|..|.:        .|.:|
Human   576 HADKKPYECKECGKAFKMYGYLTQHQKIHTGGKPYECKEC 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	56/186 (30%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	10/47 (21%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	9/23 (39%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	60/177 (34%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF573	NP_001166161.1	KRAB	28..89	CDD:214630
		KRAB	28..67	CDD:279668
		C2H2 Zn finger	136..156	CDD:275368
		C2H2 Zn finger	164..184	CDD:275368
		C2H2 Zn finger	192..212	CDD:275368
		C2H2 Zn finger	220..240	CDD:275368
		COG5048	244..628	CDD:227381	114/365 (31%)
		C2H2 Zn finger	248..268	CDD:275368	0/5 (0%)
		zf-H2C2_2	260..285	CDD:290200	7/26 (27%)
		C2H2 Zn finger	276..292	CDD:275368	5/15 (33%)
		C2H2 Zn finger	304..324	CDD:275368	7/19 (37%)
		C2H2 Zn finger	332..352	CDD:275368	3/19 (16%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		zf-H2C2_2	401..424	CDD:290200	7/24 (29%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		C2H2 Zn finger	444..464	CDD:275368	6/20 (30%)
		C2H2 Zn finger	472..492	CDD:275368	5/19 (26%)
		zf-H2C2_2	484..508	CDD:290200	7/23 (30%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		zf-H2C2_2	512..536	CDD:290200	10/23 (43%)
		C2H2 Zn finger	528..548	CDD:275368	7/19 (37%)
		C2H2 Zn finger	556..576	CDD:275368	6/22 (27%)
		C2H2 Zn finger	584..604	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..621	CDD:290200	4/20 (20%)
		C2H2 Zn finger	612..632	CDD:275368	2/4 (50%)
		zf-H2C2_2	624..649	CDD:290200
		C2H2 Zn finger	640..660	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000