DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF813

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001004301.2	Gene:	ZNF813 / 126017	HGNCID:	33257	Length:	617	Species:	Homo sapiens

Alignment Length:	327	Identity:	116/327 - (35%)
Similarity:	164/327 - (50%)	Gaps:	22/327 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQC 155
            |.:.|.:|.|.|..|::|:||..||:.|:|:||.:|||::.|..:|..| ...|...|.|.|::|
Human   297 KPYKCEECDKAFSFKSNLKRHRRIHAGEKPYKCNECGKTFSQTSSLTCH-RRLHTGEKPFKCNEC 360

  Fly   156 PKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTN 220
            .|:|:.|..|..|.|||:|||||.|:.|.|.|::...|:.|...|  |..:.:.|.:|...|:..
Human   361 GKTFSRKSSLTCHHRLHTGEKPYKCNECGKTFSQELTLKCHRRLH--TGEKPYKCNECGKVFNKK 423

  Fly   221 ANLRVHMERHEQGMEHRCSICENQFANELAL----RAHINQEHHKLTQFECEICHKMIEPDEDLA 281
            |||..|...|.....::|:.|...|:...||    ..||.::.:|     |..|.|.......|.
Human   424 ANLARHHRLHSGEKPYKCTECVKTFSRNSALVIHKAIHIGEKRYK-----CNECGKTFSRISALV 483

  Fly   282 THMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGE 346
            .|...||..|.:.|..|...|.:|:....|.|:||||:||:|..|.:.|...:.|..|.|.|||:
Human   484 IHTAIHTGEKPYKCNECGKGFNRKTHLACHHRLHTGEKPYKCNECGKVFNRKTHLAHHHRLHTGD 548

  Fly   347 KPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-HCAKCPVDGD 410
            ||::|..|..  .|:|.|||..| .::|..:|||.|..|...|..|..|..|.. |      .|:
Human   549 KPYKCNECGK--VFNQKAHLARH-HRLHTGEKPYKCNECGKVFNQKANLARHHRLH------TGE 604

  Fly   411 KP 412
            ||
Human   605 KP 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	58/155 (37%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	58/180 (32%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	7/25 (28%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF813	NP_001004301.2	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	191..602	CDD:227381	113/321 (35%)
		C2H2 Zn finger	217..237	CDD:275368
		zf-H2C2_2	230..254	CDD:290200
		C2H2 Zn finger	245..265	CDD:275368
		zf-H2C2_2	257..282	CDD:290200
		C2H2 Zn finger	273..293	CDD:275368
		zf-H2C2_2	285..309	CDD:290200	4/11 (36%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		zf-H2C2_2	313..338	CDD:290200	12/24 (50%)
		C2H2 Zn finger	329..349	CDD:275368	7/20 (35%)
		zf-H2C2_2	341..366	CDD:290200	9/25 (36%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	14/24 (58%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	398..421	CDD:290200	6/24 (25%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		C2H2 Zn finger	441..461	CDD:275368	5/19 (26%)
		C2H2 Zn finger	469..489	CDD:275368	5/19 (26%)
		C2H2 Zn finger	497..517	CDD:275368	6/19 (32%)
		zf-H2C2_2	509..534	CDD:290200	11/24 (46%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		C2H2 Zn finger	553..573	CDD:275368	8/22 (36%)
		zf-H2C2_2	565..590	CDD:290200	10/25 (40%)
		C2H2 Zn finger	581..601	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000