DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF257

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_258429.2	Gene:	ZNF257 / 113835	HGNCID:	13498	Length:	563	Species:	Homo sapiens

Alignment Length:	425	Identity:	130/425 - (30%)
Similarity:	175/425 - (41%)	Gaps:	70/425 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DDYVQPQLKKS---ARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQ 132
            |.||:...|.|   ..|....::|...|.:|.|.|...:.|.||..||..|..|||::|||::.|
Human   148 DKYVKVFYKFSNSDRHKIRHTEKKTCKCKECGKSFCMLSQLTRHKRIHIRENSHKCEECGKAFNQ 212

  Fly   133 AVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHM 197
            :..|..|..| |...|.:.|.:|.|:|.....|..|..:|:.||||.|:.|.|.|.|...:.||.
Human   213 SSALTRHKMT-HTGEKPYKCEECGKAFNRSSHLTQHKVIHTREKPYKCEECGKAFNRSSHITQHK 276

  Fly   198 VSHHKTSIQQFNCTKCSASF---STNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEH 259
            ..|::.  :.|...:|..:|   |....|..|...|.....::|..|...|....||..| ...|
Human   277 RIHNRE--KPFKYDECCKAFKWSSALTTLTQHKRIHTGEKPYKCEECGKAFNQSSALTRH-KMIH 338

  Fly   260 HKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMR----------- 313
            .....|:||.|.|.......|..|...||..|.:.||.|...|.:.|....|.|
Human   339 TGEKPFQCEECGKAFNRSSHLTQHKIIHTKEKPYKCEECGKAFNRSSHLTKHKRIHTREKAYKCD 403

  Fly   314 --------------------MHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEV 358
                                :||||:||:|..|.:.|..||.|..|...||||||::|:.|..
Human   404 EYCKAFNWSSALTTLTQHKIIHTGEKPYKCEECGKAFNRSSYLIRHKIIHTGEKPYKCEECGK-- 466

  Fly   359 AFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH-VEH-------CAKCPVDGDKPSGN 415
            ||:|.:||..| |.||..:|||.||.|...|.....|..| :.|       |.:|    .||..
Human   467 AFNQSSHLTQH-KIIHTGEKPYKCEECGKAFNRSSHLSQHKIIHTGEKPYKCEEC----GKPFN- 525

  Fly   416 QSEDAQILSVLRFNMAVVLKKISSAQKLRQLGYEK 450
                       ||:...|.|:|.:.:...:  ||:
Human   526 -----------RFSYLTVHKRIHAGENPNK--YEE 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	52/161 (32%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	60/210 (29%)
		C2H2 Zn finger	210..230	CDD:275370	5/22 (23%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/50 (14%)
		zf-H2C2_2	309..332	CDD:290200	11/53 (21%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	9/22 (41%)
		C2H2 Zn finger	382..399	CDD:275368	6/17 (35%)
ZNF257	NP_258429.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	<157..474	CDD:227381	99/322 (31%)
		C2H2 Zn finger	175..195	CDD:275368	7/19 (37%)
		C2H2 Zn finger	203..223	CDD:275368	8/20 (40%)
		zf-H2C2_2	215..240	CDD:290200	9/25 (36%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		zf-H2C2_2	243..268	CDD:290200	11/24 (46%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		C2H2 Zn finger	288..310	CDD:275368	5/21 (24%)
		zf-H2C2_2	303..327	CDD:290200	6/23 (26%)
		C2H2 Zn finger	318..338	CDD:275368	6/20 (30%)
		zf-H2C2_2	330..355	CDD:290200	9/25 (36%)
		C2H2 Zn finger	346..366	CDD:275368	6/19 (32%)
		zf-H2C2_2	358..383	CDD:290200	9/24 (38%)
		C2H2 Zn finger	374..394	CDD:275368	7/19 (37%)
		zf-H2C2_2	418..442	CDD:290200	9/23 (39%)
		C2H2 Zn finger	433..453	CDD:275368	7/19 (37%)
		zf-H2C2_2	445..470	CDD:290200	12/26 (46%)
		C2H2 Zn finger	461..481	CDD:275368	9/22 (41%)
		zf-H2C2_2	473..498	CDD:290200	13/25 (52%)
		C2H2 Zn finger	489..509	CDD:275368	6/19 (32%)
		zf-H2C2_2	501..526	CDD:290200	7/40 (18%)
		C2H2 Zn finger	517..537	CDD:275368	8/35 (23%)
		C2H2 Zn finger	545..561	CDD:275368	2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000