DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF660-ZNF197

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001338661.1	Gene:	ZNF660-ZNF197 / 110354863	-ID:	-	Length:	1029	Species:	Homo sapiens

Alignment Length:	435	Identity:	128/435 - (29%)
Similarity:	194/435 - (44%)	Gaps:	82/435 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQC 155
            |.:.|.:|.|.|...:.|..|:..||.|||:||.:|||.:.|...|.:| ...|:..:.:.|::|
Human   452 KPYKCKECGKGFYRHSGLIIHLRRHSGERPYKCNECGKVFSQNAYLIDH-QRLHKGEEPYKCNKC 515

  Fly   156 PKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSH-------------------- 200
            .|:|.||:.|.||.|:|||||||.||.|.|.||:...|..|...|
Human   516 QKAFILKKSLILHQRIHSGEKPYKCDECGKTFAQTTYLIDHQRLHSAENPYKCKECGKVFIRSKS 580

  Fly   201 ---HK---TSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELAL----RAHI 255
               |:   |..:.|.|.||...||:.:|...|...|.:...::|:.|...|.....|    |.|.
Human   581 LLLHQRVHTEKKTFGCKKCGKIFSSKSNFIDHKRMHSREKPYKCTECGKAFTQSAYLFDHQRLHN 645

  Fly   256 NQEHHKLTQ-----------------------FECEICHKMIEPDEDLATHMQRHTAVKTHVCEV 297
            .::.::..:                       :||:.|.|:...:.:|..|.:.|...|.:.|..
Human   646 GEKPYECNECGKVFILKKSLILHQRFHTGENLYECKDCGKVFGSNRNLIDHERLHNGEKPYECRE 710

  Fly   298 CNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQ 362
            |...|.....:.||.::||.|:.|:|..|.:.|:::|.|.:|.|.|||||||.|..|..  |||.
Human   711 CGKTFIMSKSFMVHQKLHTQEKAYKCEDCGKAFSYNSSLLVHRRIHTGEKPFECSECGR--AFSS 773

  Fly   363 LAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHV-----EHCAKCPVDGDKPSGNQSEDAQI 422
            ..:|..| |:||..:|||.|:.|...|.:|..|..|.     |...||           ::..::
Human   774 NRNLIEH-KRIHSGEKPYECDECGKCFILKKSLIGHQRIHTREKSYKC-----------NDCGKV 826

  Fly   423 LSVLRFNMAVVLKKISSAQK---LRQLG----YEKRLIDNVIIAS 460
            .| .|.|: :..::|.:.:|   ..:.|    |.:.||::..|.|
Human   827 FS-YRSNL-IAHQRIHTGEKPYACSECGKGFTYNRNLIEHQRIHS 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	61/181 (34%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	10/19 (53%)
		zf-H2C2_2	165..189	CDD:290200	16/23 (70%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		COG5048	<192..369	CDD:227381	57/229 (25%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	6/25 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF660-ZNF197	NP_001338661.1	SCAN	38..150	CDD:128708
		KRAB	216..256	CDD:307490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..290
		C2H2 Zn finger	372..392	CDD:275368
		zf-H2C2_2	384..409	CDD:316026
		C2H2 Zn finger	400..420	CDD:275368
		COG5048	424..853	CDD:227381	122/417 (29%)
		C2H2 Zn finger	428..448	CDD:275368
		C2H2 Zn finger	456..476	CDD:275368	6/19 (32%)
		C2H2 Zn finger	484..504	CDD:275368	7/20 (35%)
		C2H2 Zn finger	512..532	CDD:275368	10/19 (53%)
		C2H2 Zn finger	540..560	CDD:275368	8/19 (42%)
		C2H2 Zn finger	568..588	CDD:275368	1/19 (5%)
		C2H2 Zn finger	596..616	CDD:275368	7/19 (37%)
		C2H2 Zn finger	624..644	CDD:275368	5/19 (26%)
		C2H2 Zn finger	652..672	CDD:275368	0/19 (0%)
		C2H2 Zn finger	680..700	CDD:275368	5/19 (26%)
		C2H2 Zn finger	708..728	CDD:275368	5/19 (26%)
		C2H2 Zn finger	736..756	CDD:275368	7/19 (37%)
		COG5048	760..>1026	CDD:227381	36/126 (29%)
		C2H2 Zn finger	764..784	CDD:275368	8/22 (36%)
		C2H2 Zn finger	792..812	CDD:275368	6/19 (32%)
		C2H2 Zn finger	820..840	CDD:275368	4/32 (13%)
		C2H2 Zn finger	848..868	CDD:275368	4/19 (21%)
		C2H2 Zn finger	876..896	CDD:275368
		C2H2 Zn finger	904..924	CDD:275368
		C2H2 Zn finger	932..952	CDD:275368
		C2H2 Zn finger	960..980	CDD:275368
		C2H2 Zn finger	988..1008	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910