DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11247 and ZNF765-ZNF761

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001337425.1	Gene:	ZNF765-ZNF761 / 110116772	-ID:	-	Length:	746	Species:	Homo sapiens

Alignment Length:	376	Identity:	119/376 - (31%)
Similarity:	181/376 - (48%)	Gaps:	64/376 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQC 155
            |.:.|.:|.|.|..|:.|:||.:||::|:|:||.:|||::||...|..| ...|...|.:.|::|
Human   296 KPYKCEECDKAFHFKSILERHRIIHTEEKPYKCNECGKTFRQKSILTRH-HRLHTGEKPYKCNEC 359

  Fly   156 PKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTN 220
            .|:|:.|..|..|.|||:|||||.|:.|.|.|:....|..|...|  |..:.:.|.:|..::|..
Human   360 GKTFSHKSSLTCHHRLHTGEKPYKCNECGKTFSHKSSLTCHRRLH--TGEKPYKCEECDKAYSFR 422

  Fly   221 ANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQ 285
            :|..:|.:.|.:...::|:.|...|:...:|..| .:.|.....::||.|.|......:|..|.:
Human   423 SNFEIHRKIHTEDNAYKCNECGKTFSRTSSLTCH-RRRHTGEQPYKCEECDKAFRFKSNLERHRR 486

  Fly   286 RHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFR 350
            .||..|.:.|..|...|::||....|.|:||||:.|:|..|.:||:..|.|..|.|.|:||||::
Human   487 IHTGEKPYKCNECGKTFSRKSYLTCHHRLHTGEKAYKCNECGKTFSWKSSLTCHRRLHSGEKPYK 551

  Fly   351 C---------QL----------------CED-EVAFSQLAHLKNHMK------------------ 371
            |         ||                ||| :.|:|..::|:.|.|
Human   552 CKECGKTFNQQLTLKRHRRLHSGENPYKCEDSDKAYSFKSNLEIHQKIHTEENPYKCNECGKTFS 616

  Fly   372 ---------KIHKQQKPYMCEGCHDFFKIKVELQSHVE-HCAKCPVDGDKP 412
                     ::|..:|||.||.|...|::|..|:.|.. |      .|:||
Human   617 RTSSLTCHRRLHTGEKPYKCEECDKAFRVKSNLEGHRRIH------TGEKP 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	56/155 (36%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	59/202 (29%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	11/75 (15%)
		C2H2 Zn finger	382..399	CDD:275368	6/16 (38%)
ZNF765-ZNF761	NP_001337425.1	KRAB	7..48	CDD:307490
		C2H2 Zn finger	217..237	CDD:275368
		COG5048	242..617	CDD:227381	104/324 (32%)
		C2H2 Zn finger	244..264	CDD:275368
		C2H2 Zn finger	272..292	CDD:275368
		C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		C2H2 Zn finger	328..348	CDD:275368	8/20 (40%)
		C2H2 Zn finger	356..376	CDD:275368	8/19 (42%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		C2H2 Zn finger	412..432	CDD:275368	5/19 (26%)
		C2H2 Zn finger	440..460	CDD:275368	5/20 (25%)
		C2H2 Zn finger	468..488	CDD:275368	6/19 (32%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		C2H2 Zn finger	552..572	CDD:275368	3/19 (16%)
		C2H2 Zn finger	580..600	CDD:275368	8/19 (42%)
		C2H2 Zn finger	608..628	CDD:275368	0/19 (0%)
		C2H2 Zn finger	636..656	CDD:275368	7/19 (37%)
		SFP1	<651..737	CDD:227516	5/17 (29%)
		C2H2 Zn finger	664..684	CDD:275368
		C2H2 Zn finger	692..712	CDD:275368
		C2H2 Zn finger	720..740	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000