DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ERV3-1-ZNF117

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001334979.1	Gene:	ERV3-1-ZNF117 / 109504726	-ID:	-	Length:	483	Species:	Homo sapiens

Alignment Length:	398	Identity:	114/398 - (28%)
Similarity:	171/398 - (42%)	Gaps:	70/398 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 YVQ--PQLKKSAR-KGEPVKRKHHVCSQCSK----------------------------EFGGKT 106
            ||:  .::..|.| |....:.||..|.:|.|                            .|...:
Human    86 YVEVFHKISNSNRHKMRHTENKHFKCKECRKTFCMLSHLTQHKRIQTRVNFYKCEAYGRAFNWSS 150

  Fly   107 DLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRL 171
            .|.:|..||:.|:|:|||:|||::.|..:|..| ...|...|.:.|.:|.|:|.....|..|..:
Human   151 TLNKHKRIHTGEKPYKCKECGKAFNQTSHLIRH-KRIHTEEKPYKCEECGKAFNQSSTLTTHNII 214

  Fly   172 HSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEH 236
            |:||.||.|:.|.:.|.:..:|.:|.:.|  |..:::.|.:|..:|:.::.|..|...|.....:
Human   215 HTGEIPYKCEKCVRAFNQASKLTEHKLIH--TGEKRYECEECGKAFNRSSKLTEHKYIHTGEKLY 277

  Fly   237 RCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTY 301
            :|..|...|.....|..| .:.|.....::||.|.|..:...:|..|.:.||..|.:.||.|...
Human   278 KCEECGKAFNQSSTLTTH-KRIHSGEKPYKCEECGKAFKQFSNLTDHKKIHTGEKPYKCEECGKA 341

  Fly   302 FTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQ-------------- 352
            |.|.|....|..:||||:||:|..|.:.|..||.|..|...||||.|.:|:
Human   342 FNQLSNLTRHKVIHTGEKPYKCGECGKAFNQSSALNTHKIIHTGENPHKCRESGKVFHLSSKLST 406

  Fly   353 -----------LCED-EVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH-VEH--- 401
                       .||: ..||::.:.|..| |:||..:|||.||.|...|.....|.:| :.|
Human   407 CKKIHTGEKLYKCEECGKAFNRSSTLIGH-KRIHTGEKPYKCEECGKAFNQSSTLTTHKIIHTEE 470

  Fly   402 ----CAKC 405
                |.:|
Human   471 KQYKCDEC 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	50/186 (27%)
		C2H2 Zn finger	95..115	CDD:275368	6/47 (13%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	10/23 (43%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		COG5048	<192..369	CDD:227381	56/202 (28%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/48 (17%)
		C2H2 Zn finger	382..399	CDD:275368	6/17 (35%)
ERV3-1-ZNF117	NP_001334979.1	C2H2 Zn finger	111..131	CDD:275368	3/19 (16%)
		C2H2 Zn finger	139..159	CDD:275368	3/19 (16%)
		COG5048	163..>475	CDD:227381	96/316 (30%)
		C2H2 Zn finger	167..187	CDD:275368	8/20 (40%)
		C2H2 Zn finger	195..215	CDD:275368	6/19 (32%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	5/20 (25%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..407	CDD:275368	1/15 (7%)
		C2H2 Zn finger	419..439	CDD:275368	7/20 (35%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000