DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF268

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001159353.1	Gene:	ZNF268 / 10795	HGNCID:	13061	Length:	947	Species:	Homo sapiens

Alignment Length:	357	Identity:	123/357 - (34%)
Similarity:	171/357 - (47%)	Gaps:	31/357 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GEQDSKDDDYVQPQLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGK 128
            |:..|:.|..|..|...|.       :|.:||::|.|.||.|:.|..|..||:.|:|::|.:|.|
Human   366 GKVFSRKDQLVSHQKTHSG-------QKPYVCNECGKAFGLKSQLIIHERIHTGEKPYECNECQK 423

  Fly   129 SYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQL 193
            ::....||..|..| |...|.:|||.|.|:|..|.:|.:|..:|:|.|||.|..|.|.|:...||
Human   424 AFNTKSNLMVHQRT-HTGEKPYVCSDCGKAFTFKSQLIVHQGIHTGVKPYGCIQCGKGFSLKSQL 487

  Fly   194 QQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQE 258
            ..|..||  |.::.:.|.:|..:|.:.:.|.:|...|.....|.|:.|...|:.:..|..| .:.
Human   488 IVHQRSH--TGMKPYVCNECGKAFRSKSYLIIHTRTHTGEKLHECNNCGKAFSFKSQLIIH-QRI 549

  Fly   259 HHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQC 323
            |.....:||..|.|.......|.:|.:.|...|.:.|..|...|..|||..:|.|.||||:|::|
Human   550 HTGENPYECHECGKAFSRKYQLISHQRTHAGEKPYECTDCGKAFGLKSQLIIHQRTHTGEKPFEC 614

  Fly   324 RICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAF-SQL-AHLKNHMKKIHKQQKPYMCEGCH 386
            ..|.:.|...|.|.:|.|.||||||:.|..|.....| ||| .|     |.:|...|||.|..|.
Human   615 SECQKAFNTKSNLIVHQRTHTGEKPYSCNECGKAFTFKSQLIVH-----KGVHTGVKPYGCSQCA 674

  Fly   387 DFFKIKVEL----QSHVEHCAKCPVDGDKPSG 414
            ..|.:|.:|    :||.         |.||.|
Human   675 KTFSLKSQLIVHQRSHT---------GVKPYG 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	57/158 (36%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	9/24 (38%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	60/178 (34%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/24 (33%)
		C2H2 Zn finger	382..399	CDD:275368	6/20 (30%)
ZNF268	NP_001159353.1	KRAB	81..141	CDD:214630
		KRAB	81..120	CDD:279668
		C2H2 Zn finger	278..298	CDD:275368
		C2H2 Zn finger	306..326	CDD:275368
		C2H2 Zn finger	334..354	CDD:275368
		zf-H2C2_2	347..371	CDD:290200	1/4 (25%)
		C2H2 Zn finger	362..382	CDD:275368	5/15 (33%)
		zf-H2C2_2	375..397	CDD:290200	8/28 (29%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		zf-H2C2_2	403..427	CDD:290200	9/23 (39%)
		C2H2 Zn finger	418..438	CDD:275368	7/20 (35%)
		zf-H2C2_2	430..454	CDD:290200	11/24 (46%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
		COG5048	497..910	CDD:227381	70/216 (32%)
		C2H2 Zn finger	502..522	CDD:275368	5/19 (26%)
		C2H2 Zn finger	530..550	CDD:275368	5/20 (25%)
		zf-H2C2_2	543..567	CDD:290200	7/24 (29%)
		zf-C2H2	556..578	CDD:278523	6/21 (29%)
		C2H2 Zn finger	558..578	CDD:275368	5/19 (26%)
		C2H2 Zn finger	586..606	CDD:275368	8/19 (42%)
		zf-H2C2_2	599..623	CDD:290200	10/23 (43%)
		C2H2 Zn finger	614..634	CDD:275368	7/19 (37%)
		zf-H2C2_2	626..650	CDD:290200	11/23 (48%)
		C2H2 Zn finger	642..662	CDD:275368	8/24 (33%)
		C2H2 Zn finger	670..690	CDD:275368	5/19 (26%)
		C2H2 Zn finger	698..718	CDD:275368	123/357 (34%)
		zf-H2C2_2	710..734	CDD:290200
		C2H2 Zn finger	726..746	CDD:275368
		zf-H2C2_2	739..763	CDD:290200
		C2H2 Zn finger	754..774	CDD:275368
		C2H2 Zn finger	782..802	CDD:275368
		zf-H2C2_2	794..817	CDD:290200
		C2H2 Zn finger	810..830	CDD:275368
		C2H2 Zn finger	838..858	CDD:275368
		zf-H2C2_2	851..875	CDD:290200
		C2H2 Zn finger	866..886	CDD:275368
		C2H2 Zn finger	894..914	CDD:275368
		zf-H2C2_2	907..929	CDD:290200
		C2H2 Zn finger	922..942	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000