DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF605

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001158187.1	Gene:	ZNF605 / 100289635	HGNCID:	28068	Length:	672	Species:	Homo sapiens

Alignment Length:	336	Identity:	123/336 - (36%)
Similarity:	164/336 - (48%)	Gaps:	19/336 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITT 142
            |.:....||    |.:.||:|.|.|..|:.|:||.:.|:.|:|:.|.:|||::.|.:.|..| ..
Human   273 LHQRIHTGE----KPYGCSECGKAFSRKSQLKRHQITHTIEKPYSCSECGKAFSQKLKLITH-QR 332

  Fly   143 AHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQ 207
            ||...|.:.||.|.|:|..|.:|..|.|.|:|:|||.|..|.|.|:|...|.:|...|  |..:.
Human   333 AHTGEKPYPCSHCGKAFFWKSQLITHQRTHTGKKPYGCGECQKAFSRNSLLIRHQRIH--TGEKP 395

  Fly   208 FNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHK 272
            :.|.:|..:|.....|..|...|.....:|||.||..|..:..|..| .:.|.....:.|..|.|
Human   396 YECNECGEAFIRKPQLIKHQITHTGEKNYRCSDCEEAFFKKSELIRH-QKIHLGEKPYGCIQCGK 459

  Fly   273 MIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLK 337
            .......|.||.:.||..|.:.|..|...|||||....|.|.||||:||:|..|.:||:..|.|.
Human   460 TFFGKSQLLTHHRTHTGEKPYECSECGKAFTQKSSLISHQRTHTGEKPYECSECRKTFSEKSSLI 524

  Fly   338 LHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVEH- 401
            .|.|.|||||||.|..|..  ||:....|..| ::||..:|||.|..|...|..||:|..|..:
Human   525 HHQRTHTGEKPFECSECRK--AFAWKPQLLRH-QRIHTGEKPYECSECGKAFVQKVQLIKHQRNH 586

  Fly   402 -------CAKC 405
                   |:.|
Human   587 TGEKTYGCSDC 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	58/158 (37%)
		C2H2 Zn finger	95..115	CDD:275368	9/19 (47%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	63/176 (36%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	7/21 (33%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	9/19 (47%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	6/16 (38%)
ZNF605	NP_001158187.1	C2H2 Zn finger	566..586	CDD:275368	7/19 (37%)
		C2H2 Zn finger	594..614	CDD:275368	2/4 (50%)
		zf-H2C2_2	607..631	CDD:290200
		zf-C2H2	620..642	CDD:278523
		C2H2 Zn finger	622..642	CDD:275368
		C2H2 Zn finger	650..670	CDD:275368
		KRAB	7..65	CDD:214630
		KRAB	7..45	CDD:279668
		C2H2 Zn finger	176..196	CDD:275368
		COG5048	199..603	CDD:227381	123/336 (37%)
		C2H2 Zn finger	202..222	CDD:275368
		zf-H2C2_2	215..239	CDD:290200
		C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	258..278	CDD:275368	1/4 (25%)
		C2H2 Zn finger	286..306	CDD:275368	9/19 (47%)
		zf-H2C2_2	299..323	CDD:290200	10/23 (43%)
		C2H2 Zn finger	314..334	CDD:275368	7/20 (35%)
		C2H2 Zn finger	342..362	CDD:275368	9/19 (47%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		zf-H2C2_2	383..407	CDD:290200	7/25 (28%)
		C2H2 Zn finger	398..418	CDD:275368	5/19 (26%)
		C2H2 Zn finger	426..446	CDD:275368	7/20 (35%)
		C2H2 Zn finger	454..474	CDD:275368	6/19 (32%)
		zf-H2C2_2	467..491	CDD:290200	9/23 (39%)
		C2H2 Zn finger	482..502	CDD:275368	9/19 (47%)
		zf-H2C2_2	494..518	CDD:290200	11/23 (48%)
		C2H2 Zn finger	510..530	CDD:275368	8/19 (42%)
		zf-H2C2_2	522..546	CDD:290200	13/25 (52%)
		C2H2 Zn finger	538..558	CDD:275368	6/22 (27%)
		zf-H2C2_2	551..575	CDD:290200	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910