DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Gm10778

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001136435.1	Gene:	Gm10778 / 100233208	MGIID:	3809656	Length:	499	Species:	Mus musculus

Alignment Length:	328	Identity:	117/328 - (35%)
Similarity:	174/328 - (53%)	Gaps:	21/328 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCS 153
            :.|.:.|:||||.|.....||:|...|:.|:|::|..|||::.....|:.|..| |...|.|.||
Mouse   100 EEKPYECNQCSKAFANFRSLQKHEKNHTREKPYECNHCGKAFPSRSALQIHQRT-HTGEKPFDCS 163

  Fly   154 QCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFS 218
            :|.|:||....|.:|.|.|:|||||.|:.|.|.|:....||.|.:.|  |..:.:.|.:|..:|:
Mouse   164 ECGKAFARHSNLDIHKRTHTGEKPYDCNECGKAFSTRSHLQIHEIIH--TGEKPYVCNQCGKAFA 226

  Fly   219 TNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHH---KLTQFECEICHKMIEPDEDL 280
            ..:||..|.:.|.....:.|:.|.|.:|:..:||.|  ::||   ||  :.|..|.|.......|
Mouse   227 YRSNLEAHEKTHTGEKPYECNQCGNVYASRSSLRNH--EKHHTGEKL--YGCNQCGKAFARRSSL 287

  Fly   281 ATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTG 345
            ..|.:.||..|.:||..|...|.::|...:|.|.||||:||:|..|.:.||..:.|:.|.:.|||
Mouse   288 EIHERTHTGEKPYVCNQCCKAFARRSSLQIHERSHTGEKPYECNQCGKAFASRTSLQNHEKHHTG 352

  Fly   346 EKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVEH--------C 402
            |||:.|..|:.  ||.....|:.| ::||..:|||:|..|...|..:..|::|.:|        |
Mouse   353 EKPYGCNQCDK--AFELKCDLQIH-ERIHTGEKPYVCNQCGKAFVSRRYLRNHEKHHTLEKLYDC 414

  Fly   403 AKC 405
            ::|
Mouse   415 SQC 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	57/157 (36%)
		C2H2 Zn finger	95..115	CDD:275368	9/19 (47%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	61/179 (34%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	7/21 (33%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
Gm10778	NP_001136435.1	KRAB	4..>48	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	102..458	CDD:227381	117/326 (36%)
		C2H2 Zn finger	106..126	CDD:275368	9/19 (47%)
		zf-H2C2_2	118..141	CDD:290200	10/22 (45%)
		C2H2 Zn finger	134..154	CDD:275368	7/20 (35%)
		zf-H2C2_2	146..171	CDD:290200	11/25 (44%)
		C2H2 Zn finger	162..182	CDD:275368	9/19 (47%)
		zf-H2C2_2	174..199	CDD:290200	13/24 (54%)
		C2H2 Zn finger	190..210	CDD:275368	7/19 (37%)
		zf-H2C2_2	202..227	CDD:290200	8/26 (31%)
		C2H2 Zn finger	218..238	CDD:275368	6/19 (32%)
		C2H2 Zn finger	246..266	CDD:275368	7/21 (33%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	286..311	CDD:290200	9/24 (38%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		zf-H2C2_2	314..339	CDD:290200	11/24 (46%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		C2H2 Zn finger	358..378	CDD:275368	6/22 (27%)
		zf-H2C2_2	370..395	CDD:290200	10/25 (40%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		C2H2 Zn finger	414..434	CDD:275368	2/4 (50%)
		zf-H2C2_2	426..451	CDD:290200
		C2H2 Zn finger	442..462	CDD:275368
		zf-H2C2_2	454..479	CDD:290200
		C2H2 Zn finger	470..490	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910