DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF717

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_011531546.1	Gene:	ZNF717 / 100131827	HGNCID:	29448	Length:	948	Species:	Homo sapiens

Alignment Length:	428	Identity:	133/428 - (31%)
Similarity:	187/428 - (43%)	Gaps:	63/428 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VSLLTDSGISLSSPPAARESSPGPTLAIKRRKSSLASLRDACVDEEEDDGGEQDSKDDDYVQPQL 78
            |.::|..|    .|...|:|.     ..|.:::........||:.|:    ...||.|..:|.::
Human   287 VQVITQVG----QPTCCRKSD-----FTKHQQTHTGEKPYECVECEK----PSISKSDLMLQCKM 338

  Fly    79 KKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTA 143
                    |.:.|.:.|:.|.|.|..|:.|..|..||:.|:|:.|.:|||::|:...|..|..|
Human   339 --------PTEEKPYACNWCEKLFSYKSSLIIHQRIHTGEKPYGCNECGKTFRRKSFLTLHERT- 394

  Fly   144 HEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSI--Q 206
            |...|.:.|.:|.|:|..|..|.||.|.|||||||.|..|.|.|::    :.::..||:|..  :
Human   395 HTGDKPYKCIECGKTFHCKSLLTLHHRTHSGEKPYQCSECGKTFSQ----KSYLTIHHRTHTGEK 455

  Fly   207 QFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICH 271
            .:.|..|..:||..:.|.||...|.....:.|:.|...|.|:..||.| .:.|.....:||..|.
Human   456 PYACDHCEEAFSHKSRLTVHQRTHTGEKPYECNECGKPFINKSNLRLH-QRTHTGEKPYECNECG 519

  Fly   272 KMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVL 336
            |.......|..|...||..|.:.|..|...|..||...||.|.|.||:||.|..|.:|::|.|.|
Human   520 KTFHRKSFLTIHQWTHTGEKPYECNECGKTFRCKSFLTVHQRTHAGEKPYACNECGKTYSHKSYL 584

  Fly   337 KLHIRKHTGEKPFRCQLC--------------------------EDEVAFSQLAHLKNHMKKIHK 375
            .:|.|.||||||:.|..|                          |.|..|....:|..| |:.|.
Human   585 TVHHRTHTGEKPYECNECGKSFHCKSFLTIHQRTHAGKKPYECNECEKTFINKLNLGIH-KRTHT 648

  Fly   376 QQKPYMCEGCHDFFKIKVELQSHV-EHCAKCPVDGDKP 412
            .::||.|..|...|:.|..|.:|. .|      .|:||
Human   649 GERPYECNECGKTFRQKSNLSTHQGTH------TGEKP 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	56/160 (35%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	15/23 (65%)
		C2H2 Zn finger	180..200	CDD:275368	4/19 (21%)
		COG5048	<192..369	CDD:227381	61/204 (30%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	7/21 (33%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	8/48 (17%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF717	XP_011531546.1	KRAB	56..116	CDD:214630
		KRAB	56..95	CDD:279668
		C2H2 Zn finger	217..237	CDD:275368
		COG5048	343..723	CDD:227381	118/351 (34%)
		C2H2 Zn finger	347..367	CDD:275368	7/19 (37%)
		C2H2 Zn finger	375..395	CDD:275368	8/20 (40%)
		zf-H2C2_2	388..412	CDD:290200	9/24 (38%)
		C2H2 Zn finger	403..423	CDD:275368	9/19 (47%)
		zf-H2C2_2	416..440	CDD:290200	15/23 (65%)
		zf-C2H2	429..451	CDD:278523	7/25 (28%)
		C2H2 Zn finger	431..451	CDD:275368	6/23 (26%)
		zf-H2C2_2	443..468	CDD:290200	6/24 (25%)
		C2H2 Zn finger	459..479	CDD:275368	7/19 (37%)
		zf-H2C2_2	472..494	CDD:290200	6/21 (29%)
		C2H2 Zn finger	487..507	CDD:275368	7/20 (35%)
		zf-H2C2_2	499..524	CDD:290200	8/25 (32%)
		C2H2 Zn finger	515..535	CDD:275368	5/19 (26%)
		zf-H2C2_2	528..552	CDD:290200	8/23 (35%)
		C2H2 Zn finger	543..563	CDD:275368	8/19 (42%)
		C2H2 Zn finger	571..591	CDD:275368	8/19 (42%)
		zf-H2C2_2	583..608	CDD:290200	11/24 (46%)
		COG5048	595..932	CDD:227381	23/93 (25%)
		C2H2 Zn finger	599..619	CDD:275368	2/19 (11%)
		C2H2 Zn finger	627..647	CDD:275368	6/20 (30%)
		zf-H2C2_2	639..664	CDD:290200	9/25 (36%)
		C2H2 Zn finger	655..675	CDD:275368	6/19 (32%)
		zf-H2C2_2	667..692	CDD:290200	6/20 (30%)
		C2H2 Zn finger	683..703	CDD:275368
		zf-H2C2_2	779..801	CDD:290200
		C2H2 Zn finger	794..814	CDD:275368
		C2H2 Zn finger	822..842	CDD:275368
		zf-H2C2_2	835..859	CDD:290200
		C2H2 Zn finger	850..870	CDD:275368
		zf-H2C2_2	863..887	CDD:290200
		C2H2 Zn finger	878..898	CDD:275368
		zf-H2C2_2	891..913	CDD:290200
		zf-C2H2	904..926	CDD:278523
		C2H2 Zn finger	906..926	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910