DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF730

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_016881603.1	Gene:	ZNF730 / 100129543	HGNCID:	32470	Length:	514	Species:	Homo sapiens

Alignment Length:	366	Identity:	114/366 - (31%)
Similarity:	160/366 - (43%)	Gaps:	53/366 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DDYVQPQLKKSARKGEPVK---RKHHVCSQCSKEFGGKTDLQRHMLIHSDE-------------- 118
            |.||:...|.|......::   :|...|.:|.|.|...:.|.:|..||:.|
Human   159 DKYVKVFHKFSNSNRHKIRHTSKKPFKCKECGKLFCILSHLAQHKKIHTGEKSYKCEEYGKAFNE 223

  Fly   119 -------------RPHKCKDCGKSYRQAVNLKNHITT---AHEHRKQFVCSQCPKSFALKERLRL 167
                         :|:|||:|||::    |..:|.||   .|...|.:.|.:|.|.|.....|..
Human   224 SSNCTTHKRITEKKPYKCKECGKAF----NWFSHFTTHKRIHTGEKPYQCEKCGKFFNQSTNLTT 284

  Fly   168 HMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQ 232
            |.|:|:|||||.|:.|.|.|.:...|.:|...|  |..|.:.|.||..:|..::.|..|...|..
Human   285 HKRIHTGEKPYKCEECGKAFNQSSNLTEHKKIH--TKEQPYKCEKCGKAFKWSSTLTKHKRIHNG 347

  Fly   233 GMEHRCSICENQFANELALRAHINQEHHKLTQ-----FECEICHKMIEPDEDLATHMQRHTAVKT 292
            ...::|..|...|.....|      ..||:|.     ::.:.|.|.......|..|...||..|.
Human   348 EKPYKCEECGKAFNRSSTL------NRHKITHTGGKPYKYKECGKAFNQSSTLTIHKIIHTVEKF 406

  Fly   293 HVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDE 357
            :.||.|...|::.|....|.|:||||:||:|..|.:.|..||.|..|.|.||||||:.|:.|..
Human   407 YKCEECGKAFSRISHLTTHKRIHTGEKPYKCEECGRAFNQSSTLTTHKRIHTGEKPYECEECGK- 470

  Fly   358 VAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH 398
             ||::.:.|..| |.||..:|.|.|:.|...|:....|..|
Human   471 -AFNRSSTLTTH-KIIHSGEKIYKCKECGKAFRRFSHLTRH 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	55/191 (29%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	12/51 (24%)
		C2H2 Zn finger	123..144	CDD:275368	9/23 (39%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	58/181 (32%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	4/21 (19%)
		C2H2 Zn finger	267..287	CDD:275368	4/19 (21%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/17 (29%)
ZNF730	XP_016881603.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000