DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Rex2

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001171238.1	Gene:	Rex2 / 100043034	MGIID:	1328322	Length:	685	Species:	Mus musculus

Alignment Length:	422	Identity:	127/422 - (30%)
Similarity:	182/422 - (43%)	Gaps:	78/422 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GEQDS--KDDDYVQPQL-----KKSARKGEPVK-----------------RKHHVCSQCSKEFGG 104
            ||.|.  ...|.:|.|.     |||.:..|..|                 .|.:.||:|.|.|..
Mouse   198 GEFDKCFTQSDNLQSQQRIYPGKKSYKYSESDKCFTQTSHLSIHHTIHSGEKPYKCSECDKCFTD 262

  Fly   105 KTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHM 169
            |..|::|..||:.|:|:||.:|.|.:.....|:.| ...|...|.:.|::|.|.|..|..||:|.
Mouse   263 KCTLRKHQRIHTGEKPYKCSECDKCFTDKCTLRKH-QRIHTGEKPYKCNECDKCFTDKGSLRVHQ 326

  Fly   170 RLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGM 234
            |:|:|||||.|..|||.|.:...|..|...|  :..:.:.|::|...|:....||.|...|....
Mouse   327 RIHTGEKPYKCSECDKCFTQPSHLSIHRRIH--SGEKPYKCSECDKCFTDKCTLRKHQRIHTGEK 389

  Fly   235 EHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCN 299
            .::||.|:..|..:..||.| .:.|.....::|..|.|.......|..|.:.||..|.:.|..|:
Mouse   390 PYKCSECDKCFTEKFTLRKH-QRIHTGEKPYKCNECDKCFTDKGSLRVHQRIHTGEKPYKCSECD 453

  Fly   300 TYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLC---------- 354
            ..||:.|..::|.|:|:||:||:|..|.:.|...|.|.:|.|.|:||||::|..|
Mouse   454 KCFTKPSHLSIHRRIHSGEKPYKCSECDKCFTQPSPLSIHRRIHSGEKPYKCSECDKCFTDKGSL 518

  Fly   355 ----------------EDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH----- 398
                            |.:..|:|.:||..|. :||..:|||.|..|...|..|..|:.|
Mouse   519 RVHQRIHIGEKPYKCSECDKCFTQPSHLSIHC-RIHSGEKPYKCSECDKCFTHKGSLRVHHRIHA 582

  Fly   399 ------VEHCAKCPVD------------GDKP 412
                  ...|.||..:            |:||
Mouse   583 GEKPYKCSECDKCFTEKNGLRRHQRIHTGEKP 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	56/175 (32%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	5/20 (25%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	15/23 (65%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	57/202 (28%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	7/21 (33%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/48 (17%)
		C2H2 Zn finger	382..399	CDD:275368	6/27 (22%)
Rex2	NP_001171238.1	KRAB	27..67	CDD:366587
		C2H2 Zn finger	197..217	CDD:275368	6/18 (33%)
		C2H2 Zn finger	229..245	CDD:275368	1/15 (7%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		COG5048	277..666	CDD:227381	104/343 (30%)
		C2H2 Zn finger	281..301	CDD:275368	5/20 (25%)
		C2H2 Zn finger	309..329	CDD:275368	9/19 (47%)
		C2H2 Zn finger	337..357	CDD:275368	7/19 (37%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	7/20 (35%)
		C2H2 Zn finger	421..441	CDD:275368	5/19 (26%)
		C2H2 Zn finger	449..469	CDD:275368	7/19 (37%)
		C2H2 Zn finger	477..497	CDD:275368	7/19 (37%)
		C2H2 Zn finger	505..525	CDD:275368	2/19 (11%)
		C2H2 Zn finger	533..553	CDD:275368	6/20 (30%)
		C2H2 Zn finger	561..581	CDD:275368	6/19 (32%)
		C2H2 Zn finger	589..609	CDD:275368	3/19 (16%)
		C2H2 Zn finger	617..637	CDD:275368
		C2H2 Zn finger	645..665	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000