DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and RCCD1

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001017919.1	Gene:	RCCD1 / 91433	HGNCID:	30457	Length:	376	Species:	Homo sapiens

Alignment Length:	348	Identity:	80/348 - (22%)
Similarity:	123/348 - (35%)	Gaps:	105/348 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 FCSGSQELFVVLTNGSVQRQATGSGRDVGHPHAWQTLGFDPLELHAEGVRIRRVCCSAQGVVFVG 153
            ||...|||            .:|.||.|..|        .||.   .||.|.||..|.....||.
Human    14 FCGFGQEL------------GSGRGRQVHSP--------SPLR---AGVDICRVSASWSYTAFVT 55

  Fly   154 ASGETYVMGS-------CGEVFKAEQQPRHMRLYEEGKELLDLAAGNEHFVMLVAPYNLADDALQ 211
            ..|...:.||       |.:.:.:|.....:|.....:.||.:.|              |:.||:
Human    56 RGGRLELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWA--------------AESALR 106

  Fly   212 ---------LSVASAKEEPEDE------------RASVKSISSGHSERSVAANTRHL-LHQGYAL 254
                     :..|..:::|..|            ||.|...:..:...:.....|.| |...:||
Human   107 GEPLWAQNVVPEAEGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHAL 171

  Fly   255 L---HTQLFTFGASNNGLLGSGDHIRRANVMRLQKLDSMGVCSIAAGLEHTVARTLDGRLYHWGL 316
            |   ..|:|::|...:|.||.|..........|:.|..:.:..:|||..|:|..:..|.:|.||.
Human   172 LLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGW 236

  Fly   317 NNHSQL----------GEDVS------------------------SPMEITITENTAALPIEQNS 347
            |...||          ||.|:                        :|. |.:....|.|.:...|
Human   237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPF-IAVQPFPALLDLPMGS 300

  Fly   348 -ALEATCGDYHTLLLNASGQIHS 369
             |::|:||..||.::..:|::::
Human   301 DAVKASCGSRHTAVVTRTGELYT 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	13/45 (29%)
		RCC1_2	292..321	CDD:290274	10/28 (36%)
		RCC1	308..361	CDD:278826	21/87 (24%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
RCCD1	NP_001017919.1	Interaction with KDM8. /evidence=ECO:0000269\|PubMed:24981860	1..169		41/191 (21%)
		ATS1	<156..340	CDD:227511	42/169 (25%)
		RCC1 2	176..227		14/50 (28%)
		RCC1 3	229..317		21/88 (24%)
		RCC1 4	318..371		1/6 (17%)
		RCC1	319..366	CDD:395335	1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900