Protein Alignment Als2 and HERC1

DIOPT Version :9

• Sequence 1: NP_649347.1
• Gene: Als2 / 40410
• FlyBaseID: FBgn0037116
• Length: 1486
• Species: Drosophila melanogaster
• Sequence 2: XP_016878188.1
• Gene: HERC1 / 8925
• HGNCID: 4867
• Length: 4909
• Species: Homo sapiens
• Alignment Length: 1811
• Identity: 336/1811 - (18%)
• Similarity: 563/1811 - (31%)
• Gaps: 667/1811 - (36%)

  Fly    91 SGSQELFVVLTNGSVQRQATGS-GR----DVGHPHAWQTLGFDPLELHAEGVRIRRVCCSAQGVV 150
            :|....||:.|:|||:....|| ||    |..:....:.|.|:|   |..   |::|..|.
Human   410 AGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEP---HRS---IKKVSSSK---- 464

  Fly   151 FVGASGETYVMGSCGEVF---------------KAEQQPRHMRLYEEGKELLDLAAGNEHFVMLV 200
              |:.|.|....:.||||               ..::.|:.::...:||.::.::||..|...:.
Human   465 --GSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVT 527

  Fly   201 APYNLAD------DALQLSVASAKEEPEDERASVKSISSGHSERSVAANTRHLLHQGYALLHTQL 259
            ....|..      ..|....::::..|    ..||.||:.......:::|..|...|     ..:
Human   528 EDGELYTWGEGDFGRLGHGDSNSRNIP----TLVKDISNVGEVSCGSSHTIALSKDG-----RTV 583

  Fly   260 FTFGASNNGLLGSGDHIRRANVMRLQKLDSMGVCSIAAGLEHTVARTLDGRLYHWGLNNHSQLGE 324
            ::||..:||.||.||..|......::.|..|.:..:.||.:.::|.|..|::|.||.......|.
Human   584 WSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGS 648

  Fly   325 DVSSPMEITITENTAALPIEQNSALEATCGDYHTLLLNASGQIHSL------------QPAPPMR 377
            ..::.:...:.|..||..|     ::.:.||.|.|.|:...::::.            ...|..:
Human   649 SEATALRPKLIEELAATRI-----VDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITK 708

  Fly   378 HLQQSSTYAQTLLQLQLGA----AW---PRQLRLLMCSGGY-------TLQNQRQFQRQY----- 423
            ..:.|......:.|:..|.    ||   ||..:::.....|       |..:.|.|..:|
Human   709 PKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKIN 773

  Fly   424 -------------HYYLSHLQSQLQLLLKH---------------RQA----------------- 443
                         |:  |.|:..|:||..|               |||
Human   774 SEIPPLPFPSSREHH--SFLKLCLKLLSNHLALALAGGVATSILGRQAGPLRNLLFRLMDSTVPD 836

  Fly   444 ------VQTLEIW---------QRQSALEPLSALGPLLINWERI-------LCLLVATLHSLEGF 486
                  ::||.:.         :|...|..|...||  ..||.:       |.:::.:|.
Human   837 EIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGP--DRWESLSKGQRMQLDIILTSLQ----- 894

  Fly   487 YRADFVQPADLLFICHYKEYIDLFDGYTKA--YCDVFSV-NGFGEAVVAITGLSSPLAELNEESY 548
               |....|.||             ||:..  ..|:.|| .|:|              .|:::.|
Human   895 ---DHTHVASLL-------------GYSSPSDAADLSSVCTGYG--------------NLSDQPY 929

  Fly   549 VTRLFQQPFSIYQLFVQFMELLVR-----TQSEYGEHRVAWSEFARHSCISQ--------ELAVN 600
            .|:.......:.::   .|:.|:|     |...:||......:|...:..|:        ||..:
Human   930 GTQSCHPDTHLAEI---LMKTLLRNLGFYTDQAFGELEKNSDKFLLGTSSSENSQPAHLHELLCS 991

  Fly   601 TKD----FWSSND--RNPRIVQFRGRHRRVILTSALVPLKLVTSGISRSSNSF------------ 647
            .:.    |...|:  .|...|....:|.:::|..|       |...|||:|..
Human   992 LQKQLLAFCHINNISENSSSVALLHKHLQLLLPHA-------TDIYSRSANLLKESPWNGSVGEK 1049

  Fly   648 ---ILF----SDFLCQVSGNSLYSYPLTT--------LWVWTEGDSLRLTTPEKSFLVSTRSQEM 697
               :::    ...|||:. |||...|::.        |.:....|.|....|....|   ..||:
Human  1050 LRDVIYVSAAGSMLCQIV-NSLLLLPVSVARPLLSYLLDLLPPLDCLNRLLPAADLL---EDQEL 1110

  Fly   698 R-----------------------KVWLDQLQSSIIASLGKPL-----GSPV-PSYRSTGY---- 729
            :                       .|||..|:.:|...:|:.|     |||| |..:.|.|
Human  1111 QWPLHGGPELIDPAGLPLPQPAQSWVWLVDLERTIALLIGRCLGGMLQGSPVSPEEQDTAYWMKT 1175

  Fly   730 -EFS----REHPKFSRVKACGTWRKGVLHGN-----------------------CYLEYPDGSVY 766
             .||    .:.|:..:..:|  ..:..|.||                       |..| |..|::
Human  1176 PLFSDGVEMDTPQLDKCMSC--LLEVALSGNEEQKPFDYKLRPEIAVYVDLALGCSKE-PARSLW 1237

  Fly   767 CGELQHGIIEGF------GKMVIPTTGLYV-----------------GNFKGGRFHGHGVYE--- 805
            .....:.:.:.:      .:.::.|...:|                 ..::.|: |...||.
Human  1238 ISMQDYAVSKDWDSATLSNESLLDTVSRFVLAALLKHTNLLSQACGESRYQPGK-HLSEVYRCVY 1301

  Fly   806 ------MHCK--------------------DSPESEVYEGNFC------------------EGLF 826
                  :.||                    ||.:.:..|.:|.                  ||
Human  1302 KVRSRLLACKNLELIQTRSSSRDRWISENQDSADVDPQEHSFTRTIDEEAEMEEQAERDREEG-- 1364

  Fly   827 H----------GHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITN 881
            |          .|.||.....::|.......:......|...|.|:      |...||.||
Human  1365 HPEPEDEEEEREHEVMTAGNLVFVLHVTEIFQCFLSAREVARSRDR------DRMNSGAGS---- 1419

  Fly   882 RGDYFEGSFSGD-------------DLTGSGVAVFE---NDYYYEGELTLLGPN----------G 920
                  |:.:.|             ||. .|..|:.   |...:...|.:||.:          .
Human  1420 ------GARADDPPPQSQQERRVSTDLP-EGQDVYTAACNSVIHRCALLILGVSPVIDELQKRRE 1477

  Fly   921 RGEYYMPSGDACGGSGAMGTGEF-------------------------------DDTCELIGNK- 953
            .|:...||..|..|.|.|...|.                               ::...|.|.:
Human  1478 EGQLQQPSTSASEGGGLMTRSESLTAESRLVHTSPNYRLIKSRSESDLSQPESDEEGYALSGRRN 1542

  Fly   954 ----------------MFGQLSGTWDTVRIQAGELVLNRRFPKYPSSLGRQVVDHNRKWRSLFN- 1001
                            :|||||........|..:..::.:......|..|  :.|:|.|  |.|
Human  1543 VDLDLAASHRKRVYLLLFGQLSPRKKKSFKQVHDGPMHSQLESLSDSWAR--LKHSRDW--LCNS 1603

  Fly  1002 --NFESD------------LANCTASTSSSGGNQSAGTLRKSSKPTLSTAQIWNCIAVYMSKQRA 1052
              :||||            :.|..:..|...||...   .|..:.::||:...:.||  |.:|:.
Human  1604 SYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPG---FKEPEESMSTSPQASIIA--MEQQQL 1663

  Fly  1053 REGTKPGNYFNNILLSLPLPQKTSSPLAKARTTTSALSKLQTEAASALDFLGFPPRRIQSQEALN 1117
            |...:.......::|...:.:|.|..||.:|.::                 ||     ||...|.
Human  1664 RAELRLEALHQILVLLSGMEEKGSISLAGSRLSS-----------------GF-----QSSTLLT 1706

  Fly  1118 S-KPGGLQRADSLISMGHNTSR----------DLDNSSLASFQLDQSLMNSTVNGDESSTFNESF 1171
            | :...|.....|.::||...:          |...::..:.|::..:....:....|:|...:.
Human  1707 SVRLQFLAGCFGLGTVGHTGGKGESGRLHHYQDGIRAAKRNIQIEIQVAVHKIYQQLSATLERAL 1771

  Fly  1172 SKLSHNNNN----------SISKHMNNIDCSITSTTST---------TSAVLDQ----VPSFGMA 1213
            ....|:...          ::|.|...:|.|:..:|..         |..:|.|    :|..|::
Human  1772 QANKHHIEAQQRLLLVTVFALSVHYQPVDVSLAISTGLLNVLSQLCGTDTMLGQPLQLLPKTGVS 1836

  Fly  1214 LVLTEQDVTSIRLYLEQAFKDRHHPLYVLNERIANCFHYSYGYWKVKPTPILAKQAMREWESISR 1278
            .:.|...|.|.||            |.:|        ..:.|.:..|.:|
Human  1837 QLSTALKVASTRL------------LQIL--------AITTGTYADKLSP--------------- 1866

  Fly  1279 RIYRFVRKMFPALPEELCQMEGSREVISHITLLYPLVLSEGIYSTLFVLYANKYSRKDEMYRQNL 1343
                   |:..:|.:.||..  .:.::|...:|:.....||         ..:...::|....:.
Human  1867 -------KVVQSLLDLLCSQ--LKNLLSQTGVLHMASFGEG---------EQEDGEEEEKKVDSS 1913

  Fly  1344 NLAEK------LKDQELVEL-MGHESFLHNVMLDPKFVESVQTLKELQEKF-SPQDMLTVIQRST 1400
            ...||      |:.|...|| :|  .||       .|:..|.:.|.:|.|. ||        :.|
Human  1914 GETEKKDFRAALRKQHAAELHLG--DFL-------VFLRRVVSSKAIQSKMASP--------KWT 1961

  Fly  1401 QLLTEAYEHAMAANAAQLNADNMIPLT--------MLTMLRAAVPHLGAELALLDD 1448
            ::|         .|.|.....:.|||.        .|.:|.|.:|  ..|..:.||
Human  1962 EVL---------LNIASQKCSSGIPLVGNLRTRLLALHVLEAVLP--ACESGVEDD 2006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	13/45 (29%)
		RCC1_2	292..321	CDD:290274	8/28 (29%)
		RCC1	308..361	CDD:278826	13/52 (25%)
		PH-like	616..715	CDD:302622	27/148 (18%)
		VPS9	1373..1479	CDD:280383	21/85 (25%)
HERC1	XP_016878188.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900