DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and FMP25

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_013178.1	Gene:	FMP25 / 850766	SGDID:	S000004067	Length:	583	Species:	Saccharomyces cerevisiae

Alignment Length:	376	Identity:	80/376 - (21%)
Similarity:	128/376 - (34%)	Gaps:	130/376 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 NAGGELLLL---TTDHALYSAKLQANREHM---------DLQLLRTDVVD--------MDFCSGS 93
            |..||:|::   |.|  |.::::.:.|..:         |.:|....:.:        :.|.:||
Yeast   242 NKKGEILVIPIRTPD--LIASQVSSRRSKLLPWKTKLRYDWKLQTNQIFNGKEGEKRVVQFDAGS 304

  Fly    94 QELFVVLTN---------GSVQRQATGSGRDVGHPHAWQTLGFDP------LEL------HAEGV 137
            ..| |:|:|         |:.|:||..|....|.|...|...|.|      :||      ..|.|
Yeast   305 HHL-VLLSNLGKAYCCATGNDQKQAQVSKGQFGIPTFSQFDEFPPNNQLFEIELLNKFKHEGEDV 368

  Fly   138 ----RIRRVCCSAQGVVFVGASGETYVMGSCGEVFKAEQQPRHMRLYEEGKELLDLAAGNEHFVM 198
                .|:::.|.:...:.:..:||.|                              |.|...|..
Yeast   369 VRKREIKKIACGSYHTLAIDKTGEIY------------------------------AFGWNRFGQ 403

  Fly   199 LVAP--YNLADDALQLSVASAKEEPE--------------DERASVKSISSGHSERSVAANTRHL 247
            |..|  |||...:...||..| .:|.              |:..|..:|      |...:.:.|
Yeast   404 LALPISYNLEYVSFPRSVTHA-FKPHFPGMTNWKCVDIHCDDETSFVTI------RKPGSTSDH- 460

  Fly   248 LHQGYALLHTQLFTFGASNNGLLGS-GDHI---RRANVMRLQKLDSMGVCSIAAGLEHTVART-L 307
                      ..|.||   |||.|. |::.   .:.:.::: |.|...:.:.:.|.......| .
Yeast   461 ----------HYFAFG---NGLFGELGNNTFKNSQCDPIKI-KSDDKKLTNWSCGSHCVFTETEQ 511

  Fly   308 DGRLYHWGLNNHSQLG-----EDVSSPMEITIT----ENTAALPIEQNSAL 349
            :..:..||.|:|.|||     ...:.||.|...    ::|..|....||.|
Yeast   512 ENEVIAWGNNDHGQLGIGKKTMKCAKPMNIPEVLKPGQDTTDLDSIYNSKL 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	11/49 (22%)
		RCC1_2	292..321	CDD:290274	6/29 (21%)
		RCC1	308..361	CDD:278826	15/51 (29%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
FMP25	NP_013178.1	ATS1	8..577	CDD:227511	80/376 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900