DRSC/TRiP Functional Genomics Resources

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Protein Alignment Als2 and Rcbtb1

DIOPT Version :9

Sequence 1:NP_649347.1 Gene:Als2 / 40410 FlyBaseID:FBgn0037116 Length:1486 Species:Drosophila melanogaster
Sequence 2:NP_001347539.1 Gene:Rcbtb1 / 71330 MGIID:1918580 Length:531 Species:Mus musculus


Alignment Length:626 Identity:119/626 - (19%)
Similarity:198/626 - (31%) Gaps:266/626 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 EGVRIRRVC---CSAQGVVFVGASGETYVMG-----------------------SCGEVFKA--- 170
            |...||:.|   .||...::|..:.|.:|.|                       .||:..|:   
Mouse    17 EAGSIRKACVFGTSANEAIYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKSLSY 81

  Fly   171 EQQPRHMRLYEEG---------------------------------KELLDLAAGNEHFVMLVAP 202
            ...|..:...|:|                                 |:::::|.|:.|.:.|.|.
Mouse    82 GSGPHVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIEVACGSHHSMALAAD 146

  Fly   203 -------YNLADDALQLSVASAKEEPEDERAS-------VKSISSGHSERSVAANTRHLLHQGYA 253
                   ||   :..|:...|...:|...:.:       |.:|:.|.:. |:|     :|..|  
Mouse   147 GELFAWGYN---NCGQVGSGSTANQPTPRKVTNCLHTKRVVNIACGQTS-SMA-----VLDSG-- 200

  Fly   254 LLHTQLFTFGASNNGLLGSGDHIRRANVMRLQKLDSMGVCSIAAGLEHTVARTLDGRLYHWGLNN 318
                :::.:|.:.||.||.|::..:...:|:..|..|.|..|..|..||:|.|.:|.||.||.|.
Mouse   201 ----EVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEGLLYAWGANT 261

  Fly   319 HSQLG----EDVSSPMEITITENTAALPIEQNSALE-ATCGDYHTLLLNASGQIHSLQPAPPMRH 378
            :.|||    .::.||.:|.         :|:...:| |.|...||                    
Mouse   262 YGQLGTGSKNNLLSPTQIM---------VEKERVIEIAACHSTHT-------------------- 297

  Fly   379 LQQSSTYAQTLLQLQLGAAWPRQLRLLMCSGGYTLQNQRQFQRQYHYYLSHLQSQLQLLLKHRQA 443
                 :.|:|                   .||             |.|:                
Mouse   298 -----SAAKT-------------------QGG-------------HVYM---------------- 309

  Fly   444 VQTLEIW---QRQSALEP-----------LSALGPLLINWERILCL----LVATLHSLEGFYRAD 490
                  |   :.||.:.|           .:..|...::| |:|.:    .:....||:..:  |
Mouse   310 ------WGQCRGQSVILPHLTHFCCTDDVFACFGTPAVSW-RLLSVEHEDFLTVAESLKKEF--D 365

  Fly   491 FVQPADLLFICHYKEYIDLFDGYTKAYCDVFSVNGFGEAVVAITGLSSPLAELNEE-SYVTRLFQ 554
            ..:.|||.|....| ||.:.....|..|:.|.              |...:..||: ..|..:.|
Mouse   366 SPETADLKFRIDGK-YIHVHKAVLKIRCEHFR--------------SMFQSYWNEDMKEVIEIDQ 415

  Fly   555 QPFSIYQLFVQFMEL------------LVRTQSEYGEHRV----------------AWS------ 585
            ..:.:|:.|:|::..            |:...:.|.|:|:                |:|      
Mouse   416 FSYPVYRAFLQYLYTDTVDLPPEDAIGLLDLATSYCENRLKRLCQHIIKRGITVENAFSLFSAAV 480

  Fly   586 --------EFARHSCISQELAV-NTKDFWSSNDRNPRIVQF 617
                    ||....||:....| .|..||..:  .|.:.:|
Mouse   481 RYDAEDLEEFCFKFCINHLTEVTQTAAFWQMD--GPLLKEF 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Als2NP_649347.1 RCC1 258..304 CDD:278826 14/45 (31%)
RCC1_2 292..321 CDD:290274 13/28 (46%)
RCC1 308..361 CDD:278826 18/57 (32%)
PH-like 616..715 CDD:302622 1/2 (50%)
VPS9 1373..1479 CDD:280383
Rcbtb1NP_001347539.1 RCC1 1 40..91 7/50 (14%)
ATS1 43..>316 CDD:227511 67/375 (18%)
RCC1 2 93..145 6/51 (12%)
RCC1 3 147..198 10/59 (17%)
RCC1 4 199..250 16/56 (29%)
RCC1 5 252..302 19/83 (23%)
RCC1 6 304..356 12/87 (14%)
BTB_POZ_RCBTB1_CLLD7 350..466 CDD:349662 25/132 (19%)
BACK_RCBTB1 466..531 CDD:350603 12/56 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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