DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and Jph2

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001192005.1	Gene:	Jph2 / 59091	MGIID:	1891496	Length:	696	Species:	Mus musculus

Alignment Length:	279	Identity:	71/279 - (25%)
Similarity:	110/279 - (39%)	Gaps:	47/279 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   759 EYPDGSVYCGELQHGIIEGFGKMVIPT-TGLYVGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFC 822
            ::.||..|||..:.|...|.|....|. .|.|.|::..| |...|||..     |....:||.:.
Mouse     7 DFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFG-FEVAGVYTW-----PSGNTFEGYWS 65

  Fly   823 EGLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNRGDYFE 887
            :|..||.|:....|::|.||:....:..||:.:...||.||.|.:.:..:.|.|:.....|..::
Mouse    66 QGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSTNSGAKYEGTWNNGLQDGYGTETYADGGTYQ 130

  Fly   888 GSFSGDDLTGSGVAVFENDYYYEGELTLLGP------NGRGEY----YMPSGDACGG----SGAM 938
            |.|:.....|.||   .....|...:.:..|      :.|.|:    ..|...|..|    |..:
Mouse   131 GQFTNGMRHGYGV---RQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPAADGPMLPSPPV 192

  Fly   939 GTGEFDDTCELIGNKMFGQLSGTWDTVRIQA----GELVLNRRFPKYPSSLGRQVVDHNRKWRSL 999
            ..|.|..|           |..|.:..|.|.    |.|:...|..:..:|||.|        ||.
Mouse   193 PRGGFALT-----------LLATAEAARPQGLFTRGTLLGRLRRSESRTSLGSQ--------RSR 238

  Fly  1000 FNNFESDLANCTASTSSSG 1018
            .:..:|:|::..:..:|:|
Mouse   239 LSFLKSELSSGASDAASTG 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Jph2	NP_001192005.1	Bipartite nuclear localization signal. /evidence=ECO:0000269\|PubMed:30409805	345..359
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..664
		PHA03307	442..>643	CDD:223039
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:30409805	488..492
		PLN03185	4..>143	CDD:215619	41/141 (29%)
		MORN 1. /evidence=ECO:0000255	14..36		7/21 (33%)
		MORN 2. /evidence=ECO:0000255	38..59		8/26 (31%)
		MORN 3. /evidence=ECO:0000255	60..79		6/18 (33%)
		MORN 4. /evidence=ECO:0000255	82..104		6/21 (29%)
		PLN03185	103..>328	CDD:215619	40/177 (23%)
		MORN 5. /evidence=ECO:0000255	106..128		5/21 (24%)
		MORN 6. /evidence=ECO:0000255	129..151		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..192		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..273		3/12 (25%)
		MORN 7. /evidence=ECO:0000255	285..307
		MORN 8. /evidence=ECO:0000255	308..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810