DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Als2 and JPH2

DIOPT Version :9

Sequence 1:NP_649347.1 Gene:Als2 / 40410 FlyBaseID:FBgn0037116 Length:1486 Species:Drosophila melanogaster
Sequence 2:NP_065166.2 Gene:JPH2 / 57158 HGNCID:14202 Length:696 Species:Homo sapiens


Alignment Length:288 Identity:76/288 - (26%)
Similarity:111/288 - (38%) Gaps:55/288 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   759 EYPDGSVYCGELQHGIIEGFGKMVIPT-TGLYVGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFC 822
            ::.||..|||..:.|...|.|....|. .|.|.|::..| |...|||..     |....:||.:.
Human     7 DFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFG-FEVAGVYTW-----PSGNTFEGYWS 65

  Fly   823 EGLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNRGDYFE 887
            :|..||.|:....|::|.||:....:..||:.:...||.||.|.:.:..:.|.|:.....|..::
Human    66 QGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGTYQ 130

  Fly   888 GSFSGDDLTGSGVAVFENDYYYEGELTLLGP-------------NGRGEYYMPSGDACGG----S 935
            |.|:.....|.||   .....|...:.:..|             ||......|:..|..|    |
Human   131 GQFTNGMRHGYGV---RQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPASPASDGPALPS 192

  Fly   936 GAMGTGEFDDTCELIGN-------KMFGQLSGTWDTVRIQAGELVLNRRFPKYPSSLGRQVVDHN 993
            .|:..|.|  ...|:.|       ...|.|        .|.|.|:...|..:..:|:|.|     
Human   193 PAIPRGGF--ALSLLANAEAAARAPKGGGL--------FQRGALLGKLRRAESRTSVGSQ----- 242

  Fly   994 RKWRSLFNNFESDL---ANCTASTSSSG 1018
               ||..:..:|||   |:..|||:|.|
Human   243 ---RSRVSFLKSDLSSGASDAASTASLG 267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Als2NP_649347.1 RCC1 258..304 CDD:278826
RCC1_2 292..321 CDD:290274
RCC1 308..361 CDD:278826
PH-like 616..715 CDD:302622
VPS9 1373..1479 CDD:280383
JPH2NP_065166.2 MORN 1. /evidence=ECO:0000255 14..36 7/21 (33%)
MORN 2. /evidence=ECO:0000255 38..59 8/26 (31%)
MORN 3. /evidence=ECO:0000255 60..79 6/18 (33%)
MORN 4. /evidence=ECO:0000255 82..104 6/21 (29%)
MORN 106..128 CDD:280628 5/21 (24%)
MORN 5. /evidence=ECO:0000255 106..128 5/21 (24%)
MORN 6. /evidence=ECO:0000255 129..151 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 164..193 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..282 9/18 (50%)
MORN 7. /evidence=ECO:0000255 291..313
MORN 314..336 CDD:280628
MORN 8. /evidence=ECO:0000255 314..336
Bipartite nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9ET78 351..365
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..652
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9ET78 495..499
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4642
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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