DRSC/TRiP Functional Genomics Resources

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Protein Alignment Als2 and JPH1

DIOPT Version :9

Sequence 1:NP_649347.1 Gene:Als2 / 40410 FlyBaseID:FBgn0037116 Length:1486 Species:Drosophila melanogaster
Sequence 2:NP_001304759.1 Gene:JPH1 / 56704 HGNCID:14201 Length:661 Species:Homo sapiens


Alignment Length:653 Identity:125/653 - (19%)
Similarity:215/653 - (32%) Gaps:169/653 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   759 EYPDGSVYCGELQHGIIEGFGKMVIPT-TGLYVGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFC 822
            ::.||..|||..:.|...|.|....|. .|.|.|::..| |...|.|..     |....|:|.:.
Human     7 DFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHG-FEVVGGYTW-----PSGNTYQGYWA 65

  Fly   823 EGLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNRGDYFE 887
            :|..||.||....:::|.||:....:..|||.:.|.:..:|.|.:::..:.|.|......|..::
Human    66 QGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQ 130

  Fly   888 GSFSGDDLTGSGVAVFENDYYYEGELTLLGP-------------NGRGEYYMPSGDACGGSGAMG 939
            |.::|....|.||   .....|.....:..|             ||.   .:....|...|.|..
Human   131 GQWAGGMRHGYGV---RQSVPYGMATVIRSPLRTSLASLRSEQSNGS---VLHDAAAAADSPAGT 189

  Fly   940 TG----EFDDTCELIGNK---MF--GQLSGTWDTVRIQAGELVLNRRFP-KYPSSLGR------- 987
            .|    .|....||.|.|   :|  |.|.|:....:.::...:.::|.. :..:::.|       
Human   190 RGGFVLNFHADAELAGKKKGGLFRRGSLLGSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDAN 254

  Fly   988 -------------QVVDH--NRKWRSLFNNFESDLANCTASTSSSGGNQSAGTLRKSSKPTLSTA 1037
                         .|.||  .....:....:::|..|....:..|.|.:..|....:.:      
Human   255 STISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGVSERSNGMKYEGEWANNKR------ 313

  Fly  1038 QIWNCIAVYMSKQRAREGTK-PGNYFNNILLS------LPLPQ-KTSSPLAKA---RTTTSALSK 1091
            ..:.|...       .:|:| .|.|.||||:.      :|:.. ||...:.:|   ....:|:::
Human   314 HGYGCTVF-------PDGSKEEGKYKNNILVRGIRKQLIPIRHTKTREKVDRAIEGAQRAAAMAR 371

  Fly  1092 LQTEAASALDFLGFPPRRIQSQEALNSKPGGLQRADSLISMGHNTSRD------------LDNSS 1144
            .:.|.|::.............|.||.::    |..|...::....|.|            .....
Human   372 TKVEIANSRTAHARAKADAADQAALAAR----QECDIARAVARELSPDFYQPGPDYVKQRFQEGV 432

  Fly  1145 LASFQLDQSLMNSTVNGDESSTF----------NESFSKLSHNNNNSISKHMNNIDCSITSTTST 1199
            .|....::.:........||..|          .|:..|.||                  |..|:
Human   433 DAKENPEEKVPEKPPTPKESPHFYRKGTTPPRSPEASPKHSH------------------SPASS 479

  Fly  1200 TSAVLDQVPSFGMAL-----VLTEQDVTSI---------------RLYLEQAFKDRHHPLYVLNE 1244
            ...:..|.||.|..|     .:.::.||:|               .:..:..:..|||.....|.
Human   480 PKPLKKQNPSSGARLNQDKRSVADEQVTAIVNKPLMSKAPTKEAGAVVPQSKYSGRHHIPNPSNG 544

  Fly  1245 RIANCFHYSYGYWKVKPTP-------------------ILAKQAMREWESISRRIYRFVRKMFPA 1290
            .:.:.:|   ||:.....|                   ::.|.:..:| |.|:.:.:.|.|...|
Human   545 ELHSQYH---GYYVKLNAPQHPPVDVEDGDGSSQSSSALVHKPSANKW-SPSKSVTKPVAKESKA 605

  Fly  1291 LPE 1293
            .|:
Human   606 EPK 608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Als2NP_649347.1 RCC1 258..304 CDD:278826
RCC1_2 292..321 CDD:290274
RCC1 308..361 CDD:278826
PH-like 616..715 CDD:302622
VPS9 1373..1479 CDD:280383
JPH1NP_001304759.1 PLN03185 4..>143 CDD:215619 39/141 (28%)
MORN 1 14..36 7/21 (33%)
MORN 2 38..59 7/26 (27%)
MORN 3 60..82 7/21 (33%)
PLN03185 106..>325 CDD:215619 38/237 (16%)
MORN 4 106..128 5/21 (24%)
MORN 5 129..151 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 228..247 1/18 (6%)
MORN 6 281..303 4/21 (19%)
MORN 7 304..326 3/34 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 433..631 34/198 (17%)
TonB <434..>528 CDD:223880 18/111 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4642
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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