DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and sergef

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_021329502.1	Gene:	sergef / 565673	ZFINID:	ZDB-GENE-061220-11	Length:	397	Species:	Danio rerio

Alignment Length:	338	Identity:	79/338 - (23%)
Similarity:	120/338 - (35%)	Gaps:	98/338 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 SNAGGELLLLTTDHALYSAKLQANREHMDLQLLRTDVVDMDFCSGSQELFVVLTNGSVQRQATGS 112
            |||.|:|        ..||:...:.|.:.|:.....|..:  .:|.:.......:|.|.:..||.
Zfish   123 SNAFGQL--------GGSAEKTHSAEPLLLKSFHEPVTSV--AAGLRHALASTASGCVYQWGTGL 177

  Fly   113 GRDVGHPHAWQTLGFDPLELHAEGVRIRRVCCSAQGVVFVGASGETYVMGSC--------GEVFK 169
            .     .||.:.|...|:..|...    :..|...|  |...:.:..:.||.        |:||
Zfish   178 S-----SHAKRMLNPQPVPSHLSS----KEPCLVPG--FAHVTTQKVIAGSAHCACLTVNGDVF- 230

  Fly   170 AEQQPRHMRLYEEGKELLDLAAGNEHFVMLVAPYNLADDALQLSVASAKEEPEDERASVKSISSG 234
                               |...|:|..::....     .|.|.||..:...:|||  |..:.||
Zfish   231 -------------------LWGSNKHGQLISGSL-----FLPLPVALDRSMLQDER--VSDVHSG 269

  Fly   235 HSERSVAANTRHLLHQGYALLHTQLFTFGASNNGLLGSGDHIRRANVMRLQKLDS---------- 289
            .:         ||:.|..:   .::||:|.||.|.||..:|     .|..|..|.
Zfish   270 WT---------HLVAQTES---GRVFTWGRSNYGQLGQTNH-----SMEKQSCDERLVRSPVEVK 317

  Fly   290 --MGVCSIAAGLEHTVARTLDGRLYHWGLNNHSQLG----EDVSSPMEITITENTAALPIEQNSA 348
              .|...|:.|.||.:| .:.||::.||.|.|...|    :|::.|..|....:..||.|
Zfish   318 ALFGATQISCGSEHNLA-VVGGRVFSWGWNEHGMCGDGSLQDITQPQPIPALADAVALLI----- 376

  Fly   349 LEATCGDYHTLLL 361
               .||..|::.|
Zfish   377 ---GCGAGHSMAL 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	17/57 (30%)
		RCC1_2	292..321	CDD:290274	11/28 (39%)
		RCC1	308..361	CDD:278826	16/56 (29%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
sergef	XP_021329502.1	RCC1	13..387	CDD:332518	79/338 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900