Protein Alignment Als2 and jph3a

DIOPT Version :9

• Sequence 1: NP_649347.1
• Gene: Als2 / 40410
• FlyBaseID: FBgn0037116
• Length: 1486
• Species: Drosophila melanogaster
• Sequence 2: XP_693582.3
• Gene: jph3a / 565205
• ZFINID: ZDB-GENE-110408-64
• Length: 887
• Species: Danio rerio
• Alignment Length: 805
• Identity: 153/805 - (19%)
• Similarity: 250/805 - (31%)
• Gaps: 271/805 - (33%)

  Fly   759 EYPDGSVYCGELQHGIIEGFGKMVIPT-TGLYVGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFC 822
            ::.||..|||..:.|...|.|....|. .|.|.|.:..| |...|||..     |....|:|.:.
Zfish     8 DFDDGGSYCGGWEQGKAHGRGVCTGPQGQGEYAGAWSHG-FEVLGVYTW-----PSGNSYKGTWA 66

  Fly   823 EGLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNRGDYFE 887
            :|..||.||....|:.|.||:....:..||.:|...||.:|.|.:::..:.|.||...:.|..::
Zfish    67 QGKRHGIGVESKGRWEYKGEWTQGFKGRYGKLESTSSGSRYEGTWSNGLQDGYGSETYSDGGTYQ 131

  Fly   888 GSFSGDDLTGSGVAVFENDYYYEGELTLLGP---------NGRGEYYMPSGDACGGSGAMGT--- 940
            |.:......|.||   .....|.....:..|         :...|......|..|.||..|:
Zfish   132 GQWLSGLRHGYGV---RQSVPYGMAAIIFSPMCTSINSLRSDHSEGAPTPEDGSGVSGVSGSPVG 193

  Fly   941 ---------GEFDDTCELIGNKMFGQLSGTWDTVRIQAGELVLNRRFPKYPSSLGRQVVDHNRKW 996
                     .|.|...:..|......|||           |.|.|...|  |||..|:
Zfish   194 RSGFVLCAHSEADRHRKRKGRFRQSILSG-----------LKLRRSESK--SSLASQL------- 238

  Fly   997 RSLFNNFESDLANCTASTSSSGGNQSAGTLRKSSKPTLSTAQIWNCIAVYMSKQRARE------- 1054
             |..::|.|:....|.|:::|..|         |..:|..|:....:...:::..|.|
Zfish   239 -SKQSSFCSEAGMSTVSSAASDIN---------SNVSLGEAEAGGSVDATVTETYAGEWRNDMRT 293

  Fly  1055 --------------------------------GTK-PGNYFNNILLSLP----LPQKTSSPLAKA 1082
                                            ||| .|.|..|:|:|..    :|.:||....|.
Zfish   294 GWGVSHRSDGLHFEGEWFGNKRHGYGCTTFPDGTKEEGKYKQNVLVSGKRKNLIPLRTSKIREKV 358

  Fly  1083 RTTTSALSK----LQTEAASALDFLGFPPRRIQSQEALNSKPGGLQRADSLISMGHNTSRDLDNS 1143
            .....|..|    .:.:|..||..:.....:.::.|      |..|||.....:....:::|.
Zfish   359 DRALEAAEKAADIAKQKAEIALSRMSHARGKAEAAE------GVAQRALEECRLARAIAKELS-- 415

  Fly  1144 SLASF------------------QLDQSLMNSTVNGDE-------------------SSTFNESF 1171
              .||                  :.|..::::..:..|                   ||..:...
Zfish   416 --PSFHHYGNGLECQRPKHHDRKEKDHEVVSTGTDSPELCTPDTTPPVQTPDLSPVLSSPSSPPC 478

  Fly  1172 SKLSHNNNNSISKHMNNID-------------CSITST-TSTTSAVLDQVP---------SFGMA 1213
            |..:|.|.|:.....:.:|             ..|.|| ....|...:..|         |....
Zfish   479 SPPTHRNRNACFMRQSAVDEQGGAEIQVLVEGRGIDSTRAGANSWTAEMYPHRRGSKGESSRSTT 543

  Fly  1214 LVLTEQDVTSIRLYLEQAFKDRHHPLYVLNERIANCFHYSYGYWKVKPTPILAKQAMREWESISR 1278
            ..|.|::::.|..:....    |||             :..|....||...:|.:  :.|:
Zfish   544 PSLLEEEISHINGHENST----HHP-------------WENGSSNHKPIEHMAPE--KVWD---- 585

  Fly  1279 RIYRFVRKMFPALPEELCQMEGSREVISHITLLYPLVLSEGIYSTLFVLYANKYSRKDEMYRQ-- 1341
                              ||..:::...|::|                   |:.:|:..:.|:
Zfish   586 ------------------QMSSNQKPWKHVSL-------------------NQKTREHAISRERE 613

  Fly  1342 ------NLNLAE----KLKDQELVELMGHESFLHNVMLDPKFVESVQTLKELQE----------- 1385
                  |.|..:    |.|.|..: ...|:|..||.:.:.|..|...|..:.:|
Zfish   614 REHKPSNHNSVDCESSKFKPQVHI-YSNHKSAGHNNLSNHKTNEHASTNHKPKEFISAHEKPHVS 677

  Fly  1386 -KFSPQDMLTVIQRSTQLLTEAYEH 1409
             .::||:.::...:.       :||
Zfish   678 YHYNPQEHVSSYHKQ-------HEH 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383	7/49 (14%)
jph3a	XP_693582.3	MORN	107..129	CDD:280628	6/21 (29%)
		MORN	306..328	CDD:280628	1/21 (5%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900