DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Als2 and RCC2

DIOPT Version :9

Sequence 1:NP_649347.1 Gene:Als2 / 40410 FlyBaseID:FBgn0037116 Length:1486 Species:Drosophila melanogaster
Sequence 2:NP_001129676.1 Gene:RCC2 / 55920 HGNCID:30297 Length:522 Species:Homo sapiens


Alignment Length:373 Identity:77/373 - (20%)
Similarity:120/373 - (32%) Gaps:136/373 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 PASRICSNAGGELLLLT-TDHALYSAKLQANREHMDLQLLRTDVVDMDFCSGSQELFVVLTNGSV 105
            ||:  ...|||..:::| .:|.....||:.::                 |.| |.|....||..:
Human    72 PAT--AGKAGGAAVVITEPEHTKERVKLEGSK-----------------CKG-QLLIFGATNWDL 116

  Fly   106 -------QRQAT--GSGRDVGHPHAWQTLGFDPLELHAEGVRIRRVCCSAQGVVFVGASGETYVM 161
                   ::||.  ..|:::..||.:..|.         |||:|                 |.|.
Human   117 IGRKEVPKQQAAYRNLGQNLWGPHRYGCLA---------GVRVR-----------------TVVS 155

  Fly   162 GSCGEVFKAEQQPRHMRLYEEGK-------ELLDLAAGNEHFVMLVAPYNLADDALQLSVASAKE 219
            |||.        ...:.:..|||       |...|..|                           
Human   156 GSCA--------AHSLLITTEGKLWSWGRNEKGQLGHG--------------------------- 185

  Fly   220 EPEDERASVKSISSGHSER---SVAANTRHLLHQGYALLHT-QLFTFGASNNGLLGSGDHI---- 276
              :.:|.....:..|.|..   |.|....|.|    ||..| .:|.||.:..|.||.|:..    
Human   186 --DTKRVEAPRLIEGLSHEVIVSAACGRNHTL----ALTETGSVFAFGENKMGQLGLGNQTDAVP 244

  Fly   277 RRANVMRLQKLDSMGVCSIAAGLEHTVARTLDGRLYHWGLNNHSQLGEDVSS------------- 328
            ..|.:|    .:...:..:|.|.|.::.....|.||.:|...:.|||.:...             
Human   245 SPAQIM----YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDC 305

  Fly   329 ---PMEITI----TENTAALPIEQNSALEATCGDYHTLLLNASGQIHS 369
               |..:.|    |::...||:......:..||..|||:|::..::.|
Human   306 ELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFS 353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Als2NP_649347.1 RCC1 258..304 CDD:278826 12/49 (24%)
RCC1_2 292..321 CDD:290274 7/28 (25%)
RCC1 308..361 CDD:278826 17/72 (24%)
PH-like 616..715 CDD:302622
VPS9 1373..1479 CDD:280383
RCC2NP_001129676.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..83 5/12 (42%)
RCC1 1 103..165 20/96 (21%)
ATS1 <151..481 CDD:227511 53/265 (20%)
RCC1 2 168..219 15/83 (18%)
RCC1 3 221..271 12/53 (23%)
RCC1 4 273..347 18/73 (25%)
Required for interaction with RAC1. /evidence=ECO:0000269|PubMed:28869598 318..325 1/6 (17%)
RCC1 5 348..401 1/6 (17%)
RCC1 6 403..447
RCC1 7 448..501
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..522
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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