DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Als2 and Jph4

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001003711.2	Gene:	Jph4 / 445271	RGDID:	1303170	Length:	628	Species:	Rattus norvegicus

Alignment Length:	471	Identity:	114/471 - (24%)
Similarity:	168/471 - (35%)	Gaps:	137/471 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   779 GKMVIPTTGLYVGNFKGGRFHGHGV---------YE---MHCKDS------PESEVYEGNFCEGL 825
            ||......|.|||.::.||.||:||         |.   .|..:|      |....|:|::.:|.
  Rat     5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGK 69

  Fly   826 FHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNRGDYFEGSF 890
            ..|.||.|.:|:.|.||:....:...||.|. |||.:|.|::.|..:.|.|:...:.|..::|.:
  Rat    70 REGLGVERKSRWTYRGEWLGGLKGRSGVWES-VSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQW 133

  Fly   891 SGDDLTGSGVAVFENDYYYEGELTLLGP------NGRGEYYMP------SGDACGGSGAMGT-GE 942
            ......|.||.  ::..|::..| |..|      :|..:...|      .||. |||.|.|: |.
  Rat   134 QAGKRHGYGVR--QSVPYHQAAL-LRSPRRTSLDSGHSDPPTPPPPLPLPGDE-GGSPASGSRGG 194

  Fly   943 FDDTCELIGNKMFGQLSGTWDTVRIQAG------ELVLN------RRFPKYPSSLGRQVVDHNRK 995
            |    .|.|.   |...|.....|..|.      .|:|:      ||     ||||
  Rat   195 F----VLAGP---GDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRR-----SSLG--------- 238

  Fly   996 WRSLFNNFESDLANCTASTSSSGGNQS-------------------AGTLRKSSKPTLSTAQIWN 1041
              |...:..|::::...||...|...|                   ||..|...:.....:|..|
  Rat   239 --SKRGSLRSEVSSEVGSTGPPGSEASGPPIPAPPALIEGSATEVYAGEWRADRRSGYGVSQRSN 301

  Fly  1042 CI---AVYMSKQRAREG--TKP------GNYFNNILLS-------LPL-------PQKTSSPLAK 1081
            .:   ..::..:|...|  |:|      |.|..|.|:.       |||       .:|....:..
  Rat   302 GLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEG 366

  Fly  1082 ARTTTSALSK-------------LQTEAASALDFLGFPPRRI-----QSQEALNSKPGGLQRADS 1128
            ||...||..:             |:..|||::........|:     |..:.:...||...|.||
  Rat   367 ARRAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDS 431

  Fly  1129 LISMGHNTSRDLDNSS 1144
                |.:.:..||..|
  Rat   432 ----GGSDTEPLDEDS 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Jph4	NP_001003711.2	PLN03185	5..>143	CDD:215619	41/138 (30%)
		PLN03185	281..>340	CDD:215619	13/58 (22%)
		PRK07003	<369..>606	CDD:235906	17/79 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900