DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and CG6678

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_650996.1	Gene:	CG6678 / 42581	FlyBaseID:	FBgn0038917	Length:	373	Species:	Drosophila melanogaster

Alignment Length:	336	Identity:	77/336 - (22%)
Similarity:	120/336 - (35%)	Gaps:	90/336 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DMDFCSGSQELFVVLTNGSVQRQATGSGRDVGHPHAWQTLGF---------------DPLELHAE 135
            |:|..:|..||...:   |.|.|.|.|   :|..:|  .|.|               :.:.|.|.
  Fly    20 DVDCAAGFSELNAPV---STQNQCTIS---IGWRYA--ALAFGRKLCLRGLLDDGPNECVTLEAT 76

  Fly   136 GVRIRRVCCSAQGVVFVGASGETYVM---------------------GSCGEVFKAEQQPRHMRL 179
            | .||.:..:....:.:..||:.|.:                     |:...:|.|.:.|
  Fly    77 G-NIRALAAADSHCLVLLQSGQLYRVQPKLQAELVAVRLEAAPRSNSGTKRSIFGAAKAP----- 135

  Fly   180 YEEGKELLDLAAGNEHFVMLVAPYNLADDALQLSVASAKEEPEDERASVKSISSGHSERSVAANT 244
               ...:::..|...|..:.::..|..     .|:.|...:..:.:..||.:..|| |.:|..|.
  Fly   136 ---SSPIIEHIACGSHINVAISSENCV-----YSIPSCLHQFSERQFRVKQLQCGH-EHAVLLNA 191

  Fly   245 RHLLHQGYALLHTQLFTFGASNNGLLGSGDHIRRANVMRLQKLDSMGVCSIAAGLEHTVARTLDG 309
                       :..:||:|....|.||..:.........|:.|..:.:..||||..|:.|.:..|
  Fly   192 -----------NGDVFTWGNGLRGQLGLAELRVEETPQLLEALAGIKITQIAAGGWHSAAISAFG 245

  Fly   310 RLYHWGLNNHSQLGEDVSSPMEITITENTAALPIEQNSAL-EATC-----------------GDY 356
            .||.||||...|||..|..|..: :.|.| ..|:.|...| |..|                 |..
  Fly   246 DLYTWGLNCSGQLGLRVMKPGGV-LKEPT-VFPLPQLQDLPECACSQSGESNDDCAPLRVFAGSR 308

  Fly   357 HTLLLNASGQI 367
            ||||:...|::
  Fly   309 HTLLIRRCGRL 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	13/45 (29%)
		RCC1_2	292..321	CDD:290274	13/28 (46%)
		RCC1	308..361	CDD:278826	23/70 (33%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
CG6678	NP_650996.1	ATS1	<78..371	CDD:227511	60/269 (22%)
		RCC1_2	176..205	CDD:290274	10/40 (25%)
		RCC1	192..241	CDD:278826	13/48 (27%)
		RCC1_2	228..257	CDD:290274	13/28 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900