DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and CG3306

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_648335.1	Gene:	CG3306 / 39116	FlyBaseID:	FBgn0036016	Length:	288	Species:	Drosophila melanogaster

Alignment Length:	283	Identity:	57/283 - (20%)
Similarity:	95/283 - (33%)	Gaps:	90/283 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   795 GGRFHGH----GVYEMHCKDSPESEVYEGNFCEGLFHGHGVMRNNRYIYVGEYQANARSGYGVIE 855
            |.|:.|.    |:.||.....|:...|.|.|....|||.|.::....:.| .||....:|..|..
  Fly    20 GSRYVGPSDELGMQEMGVYIYPDGTCYTGEFLNNRFHGKGTIQIPDSLGV-TYQVTHHNGRLVSI 83

  Fly   856 DLVSGDKYMGMFADNKRSGIGSCITNRGDYFEGSF------SGDDLTGSGVAVFENDYYYEGE-- 912
            |.|:.:..:.:..:.|            |::..||      :.:|          ..:|.|.:
  Fly    84 DQVNFNDSLPVDFEMK------------DHYTMSFKPWTYCTPED----------RRFYQETKEP 126

  Fly   913 LTLLGPN-------------GRGEYYMPSGDACGGSGAMGTGEFDDTCELIGNKMFGQLS----- 959
            :..:|||             ||..:.:       |.|.:|...|     ::..|.|...|
  Fly   127 MDAVGPNKFQSKDGPNPLNLGRNIFDL-------GFGLLGNRGF-----MLDTKTFSNQSIYLGC 179

  Fly   960 ---GTWDTVRIQAGELVLNRRFPKYPSSLGRQVVDHNR-----------------KWRSLFNNFE 1004
               ..|.......|.|.......|..:...|:::.:|:                 |..:..::|.
  Fly   180 REARRWIRENCAHGPLSKRHHKQKLLARFAREIIRNNQENAGCSQREFMTKIHPCKHSTSLDSFA 244

  Fly  1005 SD---LANCTASTSSSGGNQSAG 1024
            |:   ||:.|.||:|..  |:.|
  Fly   245 SERLHLASTTDSTTSEA--QAMG 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
CG3306	NP_648335.1	COG4642	<36..90	CDD:226989	15/54 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900