DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and Rcc1

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster

Alignment Length:	429	Identity:	98/429 - (22%)
Similarity:	163/429 - (37%)	Gaps:	113/429 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LHWRGLPPLQRFPASRICSNAGGELLLLTTDHALYSAKLQANRE-------HMDLQLLRTDVVDM 87
            |..:.|.|:...|.:...|..|...|:||....:||  ...|.|       ..|....:.|::|:
  Fly    62 LERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYS--FGCNDEGALGRDTSEDGSESKPDLIDL 124

  Fly    88 D---FC--SGSQELFVVLTNGSVQRQATGSGRDVGHPHAWQTLGFD-----PLELHAEGVRIRRV 142
            .   .|  :|......:|.:|.|  .|.||.||   .|....|..|     |::| .||.    |
  Fly   125 PGKALCISAGDSHSACLLEDGRV--FAWGSFRD---SHGNMGLTIDGNKRTPIDL-MEGT----V 179

  Fly   143 CCS----AQGVVFVGASGETYVMGSCGEVFKAEQQPRHMRLYE-----EGKE-LLDLAAGNEHFV 197
            |||    |..:|.:..:|:.:.:| |.|      |.:..||.|     ||:. ..||....:..:
  Fly   180 CCSIASGADHLVILTTAGKVFTVG-CAE------QGQLGRLSERSISGEGRRGKRDLLRPTQLII 237

  Fly   198 MLVAPYN----------LADDALQLSVASA----KEEPEDERASVKSISSGHSE----RSVAANT 244
            ....|:.          :.:...|:..|:.    |:...:.:....:::...:|    |.:|...
  Fly   238 TRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTELKDIRHIAGGQ 302

  Fly   245 RHLLHQGYALLHTQL--FTFGASNNGLLGSG---DHIRRANVMR--LQKLDSMG---VCSIAAGL 299
            .|.:     :|.|.|  ...|....|.||.|   |.:.:..:::  .:|:.|:|   |||.|.
  Fly   303 HHTV-----ILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGEVCSYAV-- 360

  Fly   300 EHTVARTLDGRLYHWGLNNHSQL----GEDVSSPMEITITENTAALPIEQNSALEATCGDYHTLL 360
                  |:||:||.||...::||    |:|...|: :.:::||     :....|.|:.|..|.:.
  Fly   361 ------TIDGKLYSWGSGVNNQLGVGDGDDELEPI-VVVSKNT-----QGKHMLLASGGGQHAIF 413

  Fly   361 L----------------NASGQIHSLQPAPPMRHLQQSS 383
            |                :.|..|......||..::.:.:
  Fly   414 LVKADKQDQKENVPVKVSGSSSISKKDKTPPQDNVDKEA 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	14/55 (25%)
		RCC1_2	292..321	CDD:290274	11/28 (39%)
		RCC1	308..361	CDD:278826	17/56 (30%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	7/26 (27%)
		RCC1	92..141	CDD:278826	9/50 (18%)
		RCC1_2	131..158	CDD:290274	9/31 (29%)
		RCC1	144..193	CDD:278826	20/58 (34%)
		RCC1_2	182..209	CDD:290274	8/33 (24%)
		RCC1	363..414	CDD:278826	17/56 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900