DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Als2 and CG8060

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster

Alignment Length:	1291	Identity:	260/1291 - (20%)
Similarity:	435/1291 - (33%)	Gaps:	377/1291 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 HMDLQLLRTDVVD-----------MDFCSGSQELFVVLTNGSVQRQAT----GSGRDVGHPHAWQ 123
            ||.....|.::::           .|:.|||..|...|..||:.....    |:.
  Fly    62 HMSASTARYEILEWLLNHGAYINGQDYESGSSPLHRALYYGSIDCAVLLLRYGAS---------- 116

  Fly   124 TLGFDPLELHAEGVR--IRRVC--C-------SAQGVVFVGASGETYVMGSCGEVFKAEQQPRHM 177
                  |||..|..|  ::.:|  |       .:|..|.|..|.:.|.:|...|  :....|:.:
  Fly   117 ------LELLDEDTRCPLQAICRKCDDDDLATDSQNDVLVWGSNKNYNLGIGNE--QNTNTPQAV 173

  Fly   178 RLYEEGKELLDLAAGNEHFVMLVAPYNLADDAL------------QLSVASAKEEPEDERASVKS 230
            ..:.:....|:..|       |.|.::|..|..            :|.:......|..:|..|.|
  Fly   174 DFFRKSNLWLEQVA-------LGAYHSLFCDKKGHLYAVGHGKGGRLGIGLENSLPAPKRVKVSS 231

  Fly   231 ISSGHSERSVAANTRHLLHQGYALLHTQL-FTFGASNNGLLGSGDHIRR----ANVMRLQKLDSM 290
            ..||.|.:.::.:.:|.|    .|.|..| |..|.:.:..||..|...:    ..|:.|:...:.
  Fly   232 KLSGDSIQCISVSRQHSL----VLTHQSLVFACGLNTDHQLGVRDAAEQLTQFKEVVALRDKGAS 292

  Fly   291 GVCSIAAGLEHTVARTLDGR-LYHWGLNNHSQLG-----EDVSSPMEITITENTAALPIEQNSAL 349
            .:..:.|..:|::|  ...| :|.||. |..|.|     ..::.|..|.:...|....:|.|:|.
  Fly   293 DLVRVIACDQHSIA--YGSRCVYVWGA-NQGQFGINSNTPSITVPTLIKLPAKTTIRFVEANNAA 354

  Fly   350 EATCGDYHTLLLNASGQIHSLQPAPPMRHLQQSSTYAQTLLQLQLGAAWPRQLRLLMCSGGYTL- 413
            .....:...:.|..:.:...:: .|....|:..|.....|.....|:|  ..|:|||.:....:
  Fly   355 TVIYNEEKIITLCYADKTRYIK-TPNYEDLKSISVMGGNLKNSTKGSA--AALKLLMLTETNVVY 416

  Fly   414 ---QNQRQFQRQYHYYLSHLQSQLQLLLKHRQAVQTLE---IWQ---RQSALEPLSALGP----L 465
               :|.:||.| .::....|....::|.|..|.:...|   :::   .|.|| |.|||..    .
  Fly   417 LWYENTQQFYR-CNFSPIRLHQIKKILYKCNQVMVLSEDGCVYRGKCNQIAL-PSSALQEKSRGS 479

  Fly   466 LINWE-------RILCLLVATLHSLEGFYRADFVQPADLLFICHYKEYIDLFDGYTKAYCDVFSV 523
            |.||:       .|         |.|...|.:.             :.:...|..|..:||
  Fly   480 LDNWQDNDQNKTEI---------SREHVIRIEL-------------QRVPNIDRATYIFCD---- 518

  Fly   524 NGFGEAVVAITGLSSPLAELNEESYVTRLFQQPFSIYQLFVQFMELLVRTQSEYGEHRVAW---- 584
            .||....|.            :||: |:.|::| |:.:....|.:||..|......|.|.:
  Fly   519 EGFSSFAVL------------QESH-TKYFRKP-SLPRREHSFKKLLHETSDCDAVHDVVFHVDG 569

  Fly   585 SEFARHSCISQELAVNTKDF---WSSNDRNPRIVQFRGRHRRVILTSALVPLKLVTSGISRSSNS 646
            .:||.|..|....|...:|.   :...|.........|:...:||
  Fly   570 EKFAAHKFIIYSRAPGLRDLIRCYLDKDIYLNFDHLTGKMFELIL-------------------- 614

  Fly   647 FILFSDFLCQVSGNSLYSYPLTTLWVWTEGD------SLRLTTPEKSFLVSTRSQEMRKVWLDQL 705
                         |.:||    :.|. ||.|      ||....|::    .||:.||   :|..|
  Fly   615 -------------NHIYS----SYWP-TEDDIDCIQQSLGPANPQQ----RTRTCEM---FLPHL 654

  Fly   706 QSSIIASLGKPLGS-------PVPSYRSTGYEFSR----EHPKFSRVKACGTWRKGVLHGNCYLE 759
            :...:..|.|.:.|       |:|:.|..   |:|    :||                      |
  Fly   655 EKFQLVELTKYVQSYVRDHQFPLPNARKL---FNRLYRSDHP----------------------E 694

  Fly   760 YPDGSVYCGELQHGIIEGFGKMVIPTTGLYVGNFKGGRFHGHGVYEMHCKDSPESEVYEG---NF 821
            ..|..:.|   :.|.:.|..|.::.           .|.....:..||......|...||   .:
  Fly   695 LYDVRIVC---KDGKVLGAHKCMLV-----------ARLEYFEMMFMHLWAERSSVTMEGVPAEY 745

  Fly   822 CEGLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSG-----DKYMGMFADNKRSGIGSCITN 881
            .|.:..         |:|..:.:|..:.||  :|..:..     |:|   |.::.::...|.|.:
  Fly   746 MEPVLD---------YLYSLDNEAFCKQGY--LETFLYNMITICDQY---FIESLQNVCESLILD 796

  Fly   882 R------GDYFEGSFSGDDLTGSGVAVFENDYYYEGELTLLGPNGRGEYYMPSGDACGGSGAMGT 940
            :      |:..|.:           |::......:|.:..:..|........|.:.|.|
  Fly   797 KISIRKCGEMLEFA-----------AMYNCKILQKGCMDFICQNLSRVLCYRSIEQCDG------ 844

  Fly   941 GEFDDTCELIGN---KMF------GQLSGTWDTVR-------IQAGELVLNRRFPKYPSSLGRQV 989
                :|.:.:.:   |||      .|::...:.:.       :...::.||.|..  ..|..:|.
  Fly   845 ----ETLKCLNDHYRKMFKRVFDYRQITPFSEAIEDELLLSFVDGCDVDLNYRMD--AESKLKQA 903

  Fly   990 VDHNRK---WRSLFNNFESD-LANCTASTSSSGGNQSAGTLRKSSKPTLSTAQIWNCIAVYMSKQ 1050
            ..|.:|   .:...:.:|.. :::...|.|.|...|  ||...||....:.::..|...|...|.
  Fly   904 AKHKQKDLRKQDARHQYEQQAISSMMRSLSISESTQ--GTEVPSSPQDSARSEDKNWSRVVDKKD 966

  Fly  1051 RAREGTKPGNYFNNILL-------------SLPLPQKTSSPLAKARTTTSALSKLQTEAASALDF 1102
            :.|:..:.....||.|.             ..||.::|..|.:.....|:.|||     :..|||
  Fly   967 QKRKLAETALKVNNTLKHEDPPTQELVPIERKPLKEQTPPPPSHETEPTTPLSK-----SYNLDF 1026

  Fly  1103 LGFPPRRIQSQEALNSKPGGLQRADSLISMGHNTSRDLDNSSLASFQLDQSLMNST--------- 1158
            ....|   |||: |:.|.  .:|..|     .:.|...:|..|    ::||   ||
  Fly  1027 SSLTP---QSQK-LSQKQ--RKRLSS-----ESKSWRTNNPPL----VEQS---STPVAVPNAWG 1073

  Fly  1159 VNGDESSTFNESFSKLSHNNNNSISKHMNNIDCSITSTTSTTSAVLDQVPSFGMAL 1214
            |....|.:||:||:..:..::...:...|.:....||:|:.|    ||..||...|
  Fly  1074 VTTTPSGSFNDSFTSPTTGSSTDPTSFANMMRGHATSSTTPT----DQSQSFSRIL 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	10/50 (20%)
		RCC1_2	292..321	CDD:290274	8/29 (28%)
		RCC1	308..361	CDD:278826	13/58 (22%)
		PH-like	616..715	CDD:302622	20/104 (19%)
		VPS9	1373..1479	CDD:280383
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	19/91 (21%)
		ANK repeat	56..87	CDD:293786	3/24 (13%)
		Ank_4	57..111	CDD:290365	11/48 (23%)
		ANK repeat	89..121	CDD:293786	11/47 (23%)
		Ank_2	95..>138	CDD:289560	12/58 (21%)
		RCC1	147..195	CDD:278826	11/56 (20%)
		RCC1	199..251	CDD:278826	10/55 (18%)
		BTB	547..>635	CDD:295341	23/125 (18%)
		BTB	684..795	CDD:279045	27/160 (17%)
		BTB	697..798	CDD:197585	23/128 (18%)
		SPOP_C_like	798..>834	CDD:269810	5/46 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900