DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Als2 and Rpgr

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_038955861.1	Gene:	Rpgr / 367733	RGDID:	1560136	Length:	1380	Species:	Rattus norvegicus

Alignment Length:	241	Identity:	58/241 - (24%)
Similarity:	98/241 - (40%)	Gaps:	40/241 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 LAAGNEHFVMLVAP---YNLADD---ALQLSVASAKEEPEDERA----SVKSISSGHSERSVAAN 243
            |:.|:||..::...   |....:   .|.|...||..:|...:|    .||..:.|.:...|:.:
  Rat    78 LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCIKALKPEKVKLAACGRNHTLVSTD 142

  Fly   244 TRHLLHQGYALLHTQLFTFGASNNGLLGSGDHIRRANVMRLQKLDSMGVC-SIAAGLEHTVARTL 307
            |            ..::..|.:|.|.||.||...|....::.......:. .::||...:.|.|.
  Rat   143 T------------GGVYAAGGNNEGQLGLGDTDDRDTFHQIGFFTPSDIIKQLSAGANTSAALTE 195

  Fly   308 DGRLYHWGLNNHSQLG----EDVSSPMEITITENTAALPIEQNSALEATCGDYHTLLLNASGQIH 368
            ||:|:.||.|:..|:|    .:|..|.|:|:.:     ||...|     ||.||:..:...|:::
  Rat   196 DGKLFMWGDNSEGQIGLKNKSNVCIPHEVTVGK-----PISWIS-----CGYYHSAFVTTDGELY 250

  Fly   369 SL-QPAPPMRHLQQSSTYAQTLLQLQLGAAWPRQLRLLMCSGGYTL 413
            :. :|......|...........|..||.  |.::..:.|.||:|:
  Rat   251 TFGEPENGKLGLPNQLLINHRSPQRVLGI--PDKVIQVACGGGHTV 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	10/46 (22%)
		RCC1_2	292..321	CDD:290274	10/29 (34%)
		RCC1	308..361	CDD:278826	19/56 (34%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Rpgr	XP_038955861.1	ATS1	<78..368	CDD:227511	58/241 (24%)
		RCC1	352..398	CDD:395335
		MDN1	<625..904	CDD:227596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900