DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Als2 and Als2

DIOPT Version :9

Sequence 1:NP_649347.1 Gene:Als2 / 40410 FlyBaseID:FBgn0037116 Length:1486 Species:Drosophila melanogaster
Sequence 2:NP_001013431.1 Gene:Als2 / 363235 RGDID:1310372 Length:1651 Species:Rattus norvegicus


Alignment Length:1699 Identity:395/1699 - (23%)
Similarity:644/1699 - (37%) Gaps:519/1699 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 LPPLQRFPASRICSNAGGELLLLT--TDHALYS-----------AKLQANR----------EHMD 76
            |||....|....|:.....|:.:|  .||.:.|           ::.||.:          |.:|
  Rat   220 LPPQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTLSESQAEKHASTVTSPHPETLD 284

  Fly    77 LQ--LLRTDVVDMDFCSGSQELFVVLTNG---SVQRQATG-----SGRDV-GHPHAWQTLGF--- 127
            .|  :....|.:.:...||.:    .|:|   |.|:...|     |.|.. .:|.......:   
  Rat   285 GQGEVFENTVAEAELNMGSDQ----TTSGSAISAQQNIVGMAEVSSARTAPSYPDTQTVTAYLQK 345

  Fly   128 -------------------DPL------ELHAEGVRIRRV-------CCSAQGVVFVGASGETYV 160
                               .||      :||:........       |.||.||    ....||.
  Rat   346 LSEHSVKENHEREEKLPQVQPLVEEAVPDLHSPPTTSTSALNSLVVSCASAVGV----RVAATYE 406

  Fly   161 MGSCGEVFKAEQQPRHMRLY-----EEGKELLDLAAGNEHFVMLVAPYNLAD--------DALQL 212
            .|       |....:.|..|     |.|......:.|         |.:|.|        ::||.
  Rat   407 AG-------ALSLKKVMNFYSTAPCEPGAPSGTASTG---------PESLKDLREEQVKQESLQG 455

  Fly   213 SVASA-----KEEPE--DERASVKSISSGHSER----SVAANTRHLL----HQGYA-----LLHT 257
            ..:|:     :||.|  ..|.|:..:.|..|.|    :....||.::    :.|.|     .|.|
  Rat   456 KKSSSLMDIREEESEGGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRT 520

  Fly   258 QLFTFGASNNGLLGSGDHIRRANVMRLQKLDSMGVCSIAAGLEHTVARTLDGRLYHWGLNNHSQL 322
            :::|:|....|.||.||.:.|...:.::.||...|..:.||..|::|.|...::|.||.|...||
  Rat   521 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNTFGQL 585

  Fly   323 GEDVSSPMEITITENTAALPIEQNSALEATCGDYHTLLLNASGQIHSLQPAPPMRHL-QQSSTYA 386
            |..     |...|....:....::.......|..::|.|     :.:....|.:.:. :|.....
  Rat   586 GHS-----EFPTTVPRLSKVSSESGVWSVAAGHGYSLFL-----VDTEDFQPGLYYSGRQDRAEG 640

  Fly   387 QTLLQLQLGAAWPRQLRLLMCSG-----------------------GY--TLQNQRQFQRQYHYY 426
            .||.:...|...|   .||.||.                       ||  :|......:|:::..
  Rat   641 DTLPENPSGTTTP---VLLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSK 702

  Fly   427 LSHLQSQL---QLLLKHRQAVQTLEIWQRQSALEPLSALGPLLINWERILCLLV----ATLHS-L 483
            ||.::||:   .|.|:|...|.|:::.|     |..|....        ||.|:    |:|.| |
  Rat   703 LSEIKSQILRPLLSLEHLGTVTTVQLLQ-----EVASRFSK--------LCYLIGQHGASLSSYL 754

  Fly   484 EGFYRADFVQPADLLFICHYKEYIDLFDGYTKAYCDVFSVNGF----GEAVVAITG--------- 535
            :|...|     .:|:.:.|...::   |.||: ||.  ||:.|    |..::|...         
  Rat   755 QGMKEA-----RNLVIMKHSSLFL---DSYTE-YCT--SVSNFLVMGGSQLLAKPAIDFLNKNQE 808

  Fly   536 LSSPLAELNEESYVTRLFQQPFSIYQLFVQ----FMELLVR-------TQSEY---GEHRVAWSE 586
            |...|:|:|:|:  |:|.:...:::.|.::    :.::|::       |..||   .:....:..
  Rat   809 LLQDLSEVNDEN--TQLMEILNALFFLPIRRLHNYAKVLLKLATCFEVTSPEYQKLQDSSSCYES 871

  Fly   587 FARHSCISQELAVNTKDFWSSNDRNPRIVQFRGR--------HRRVILTSALVPLKLVTSGISRS 643
            .|.|....::.|..|..||.:         |.|:        .||::..|:...|.|..:| ..|
  Rat   872 LALHLGKKRKEAEYTLSFWKT---------FPGKMTDSLRKPERRLLCESSNRALSLQHAG-RFS 926

  Fly   644 SNSFILFSDFLCQVSGNSLYSYPLTTLWV-----WTEG-DSLRLTTPEKSF-LVSTRSQEMRKVW 701
            .|.||||:|.|.....::.:.:||.|||.     .|.| :.|::||||:.| |:|:..||..| |
  Rat   927 VNWFILFNDALVHAQFSTHHVFPLATLWAEPLSEETGGVNGLKITTPEEQFTLISSTPQEKTK-W 990

  Fly   702 LDQLQSSIIASLGKPLGSPV------------PSYRSTGYEFSREHPKFSRVKAC---GTWRKGV 751
            |..:..::..:|......|:            |..||..|.|.::    :|:|..   |.|..|.
  Rat   991 LRAISQAVDQALRGTSDFPLYGGSSTVQRQEPPISRSAKYTFYKD----TRLKDATYDGRWLSGK 1051

  Fly   752 LHGNCYLEYPDGSVYCGELQHGIIEGFGKMVIPTTGL-----YVGNFKGGRFHGHGVYEMHCKDS 811
            .||...|::|||.||.|..::|:.:|:|:..||...|     |||::|.|:..|.|||..     
  Rat  1052 PHGRGVLKWPDGKVYSGTFRNGLEDGYGEYRIPNKALNKEDHYVGHWKEGKMCGQGVYSY----- 1111

  Fly   812 PESEVYEGNFCEGLFHGHGVMRNNRY------IYVGEYQANARSGYGVIEDLVSGDKYMGMFADN 870
            ...||:||.|.:.:.||||::|:.:.      :::|::..:.::||||.:|:..|:|||||:.|:
  Rat  1112 ASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDD 1176

  Fly   871 KRSGIGSCITNRGDYFEGSFSGDDLTGSGVAVFENDYYYEGEL----TLLGPNGRGEYYMPSGDA 931
            ...|.|..:|..|.|:||:|..:.:.|:||.:.|:|..||||.    ||.   |:|...||:||.
  Rat  1177 ACQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLC---GKGTLTMPNGDY 1238

  Fly   932 CGG--SGAMGTGEFDDTCELIGNKMFGQLSGTWDTVRIQAGELVLNRRFPKYPSSLGRQVVDHNR 994
            ..|  ||..|:|.              :::||:....:...:    :..||....||...|..:.
  Rat  1239 IEGYFSGEWGSGI--------------KITGTYFKPSLYESD----KDRPKAFRKLGNLAVAADE 1285

  Fly   995 KWRSLFNNFESDLANCTASTSSSGGNQSAGTLRKSSKPTLSTAQIWNCIAVYMSKQRAREGTKPG 1059
            |||::|:       .|..........|  |.:.|:          |:.|||.::..|.:....| 
  Rat  1286 KWRAVFD-------ECWRQLGCESPGQ--GEVWKA----------WDNIAVALTTNRRQHKDSP- 1330

  Fly  1060 NYFNNILLSLPLPQKTSSPLAKARTTTSALSKLQTEAASALDFLGFPPRRIQSQEALNSKPGGLQ 1124
                                       ..||:.||:...:|:::   |:.:              
  Rat  1331 ---------------------------EILSRSQTQTLESLEYI---PQHV-------------- 1351

  Fly  1125 RADSLISMGHNTSRDLDNSSLASFQLDQSLMNSTVNGDESSTFNESFSKLSHNNNNSISKHMNNI 1189
                                 .:|                                |:.|:    
  Rat  1352 ---------------------GAF--------------------------------SVEKY---- 1359

  Fly  1190 DCSITSTTSTTSAVLDQVPSFGMALVLTEQDVTSIRLYLEQAFKDRHHPLYVLNERIANCFHYSY 1254
                                            ..|:.||.:|.....|||..|.|.:...:..:|
  Rat  1360 --------------------------------DDIKKYLIKACDTPLHPLGRLVETLVAVYRMTY 1392

  Fly  1255 -GYWKVKPTPILAKQAMREWESISRRIYRFVRKMFPALPEE----------------LCQ-MEGS 1301
             |   |.....|.::|::|.:|..:||::.||.:||.||||                .|. ...|
  Rat  1393 VG---VGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTVPLSAPLPTGRRSFCTGKSDS 1454

  Fly  1302 RE-------VISHITLLYPLVLSEGIYSTLFVLYANKYSRKDEMYRQNLNLAEKLKDQELVELMG 1359
            |.       |::...||.|::|.. :|..||:|||....|::::|.:.:....|..|..|:..:|
  Rat  1455 RSESPEPGYVVTSSGLLLPVLLPR-LYPPLFMLYALDNDREEDIYWECVLRLNKQPDIALLGFLG 1518

  Fly  1360 HESFLHNVML--------------DPKFVESVQTLKELQEKFSPQDMLTVIQRSTQLLTEAYEHA 1410
            .:.......|              |..|..:|:.|:::...|:|.|.|.|||   |...|..:..
  Rat  1519 VQRKFWPATLSILGESKKVLPSTKDACFASAVECLQQISTTFTPSDKLKVIQ---QTFEEISQSV 1580

  Fly  1411 MAANAAQL--NADNMIPLTMLTMLRAAVPHLGAELALLDDLTGGPNFQAEMNGMAGYCYTTLKAA 1473
            :|:.....  :.|::.|:.:..:|||.:.:||:|:.|::||. .|..|   :|..|..:|||||.
  Rat  1581 LASLQEDFLWSMDDLFPVFLYVVLRARIRNLGSEVHLIEDLM-DPYLQ---HGEQGIMFTTLKAC 1641

  Fly  1474 YEHVTSRAL 1482
            |..:....|
  Rat  1642 YYQIQREKL 1650

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Als2NP_649347.1 RCC1 258..304 CDD:278826 14/45 (31%)
RCC1_2 292..321 CDD:290274 10/28 (36%)
RCC1 308..361 CDD:278826 11/52 (21%)
PH-like 616..715 CDD:302622 37/113 (33%)
VPS9 1373..1479 CDD:280383 34/107 (32%)
Als2NP_001013431.1 RCC1 1 59..108
RCC1_2 93..122 CDD:290274
RCC1 2 109..167
RCC1 109..165 CDD:278826
RCC1 3 169..218
RCC1 170..216 CDD:278826
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..476 10/31 (32%)
RCC1 4 519..570 6/51 (12%)
RCC1 521..568 CDD:278826 5/47 (11%)
RCC1 5 572..621 16/76 (21%)
RCC1 573..619 CDD:278826 15/70 (21%)
RhoGEF 689..873 CDD:295373 56/224 (25%)
PH_alsin 899..1004 CDD:241423 37/124 (30%)
PH 920..998 CDD:278594 29/85 (34%)
COG4642 1043..1182 CDD:226989 45/144 (31%)
MORN 1 1043..1065 9/21 (43%)
MORN 1043..1063 CDD:280628 9/19 (47%)
MORN 2 1066..1088 8/21 (38%)
MORN 3 1094..1116 11/25 (44%)
MORN 1094..1114 CDD:280628 10/23 (43%)
MORN 4 1117..1139 5/23 (22%)
MORN 5 1145..1167 4/21 (19%)
COG4642 1166..>1266 CDD:226989 17/99 (17%)
MORN 6 1169..1191 7/21 (33%)
MORN 7 1192..1214 3/21 (14%)
MORN 8 1215..1238 5/22 (23%)
VPS9 1548..1647 CDD:280383 28/114 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 51 1.000 Domainoid score I11303
eggNOG 1 0.900 - - E1_COG4642
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 297 1.000 Inparanoid score I2642
OMA 1 1.010 - - QHG47592
OrthoDB 1 1.010 - - D25604at33208
OrthoFinder 1 1.000 - - FOG0002992
OrthoInspector 1 1.000 - - otm46008
orthoMCL 1 0.900 - - OOG6_106878
Panther 1 1.100 - - LDO PTHR46089
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.840

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