DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Als2 and Rcc1l

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001101802.1	Gene:	Rcc1l / 360796	RGDID:	1307558	Length:	461	Species:	Rattus norvegicus

Alignment Length:	407	Identity:	92/407 - (22%)
Similarity:	134/407 - (32%)	Gaps:	132/407 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DSALGGQEERESFTIYHEGRELQLHWRGLP-PLQRFPASRI----CSNAGGELLLLTTDHALYS- 65
            ||.||....|:..|   .|.|..|....:| ||.|...:::    |..|  ..|:||....::|
  Rat   136 DSQLGFHRSRKDKT---RGYEYVLEPSPVPLPLDRPQETKVLQVSCGRA--HSLVLTDREGVFSM 195

  Fly    66 ---AKLQANREHMD------------LQLLRTDVVDMDFCSGSQELFVVLTNGSVQRQATGSGRD 115
               |..|..|:.::            :|.....||.: .|.....||:. ..|.|  .:.|.|.|
  Rat   196 GNNAHGQCGRKVVEDEVYSESHKVHRMQDFEGQVVQV-VCGQDHSLFLT-DKGEV--YSCGWGAD 256

  Fly   116 ----VGHPHAWQT---LGFDPLELHAEGVRIRRV-----CC---SAQGVVFVGASGETYVMGSCG 165
                :||.:...|   ||.|     ..||.:.:|     ||   ||.|.||
  Rat   257 GQTGLGHYNITSTPSKLGGD-----LAGVTVVQVATYGDCCLALSADGGVF-------------- 302

  Fly   166 EVFKAEQQPRHMRLYEEGKELLDLAAGNEHFVMLVAPYNLADDALQLSVASAKEEPEDERASVKS 230
                                    ..||..::.|.:    ..|:.|::|....  |......||.
  Rat   303 ------------------------GWGNSEYLQLAS----VTDSTQVNVPRCL--PFSGVGKVKQ 337

  Fly   231 ISSGHSERSVAANTRHLLHQGYALLHTQLFTFGASNNGLLGSGDHIRRANVMRLQKLDSMG---- 291
            ::.|.:..::.....|:...||               |:||.|.::....:..:......|
  Rat   338 VACGGTGCAILNEEGHVFVWGY---------------GILGKGPNLSETALPEMIPPTLFGLTEF 387

  Fly   292 -----VCSIAAGLEHTVARTLDGRLYHWGLNNHSQLG----EDVSSPMEITITENTAALPIEQNS 347
                 |..|..||.|..|.|..|.|:.||.|....||    ||...|..:|       :|.|
  Rat   388 NPEVKVSQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT-------MPGE--- 442

  Fly   348 ALEATCGDYHTLLLNAS 364
            .::..||..|.:.|..|
  Rat   443 PVDVACGVDHMVTLAKS 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	10/54 (19%)
		RCC1_2	292..321	CDD:290274	12/28 (43%)
		RCC1	308..361	CDD:278826	16/56 (29%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Rcc1l	NP_001101802.1	RCC1	127..186	CDD:278826	16/54 (30%)
		RCC1_2	173..202	CDD:290274	7/30 (23%)
		RCC1	192..242	CDD:278826	9/50 (18%)
		RCC1_2	229..258	CDD:290274	10/32 (31%)
		RCC1	245..295	CDD:278826	16/56 (29%)
		RCC1	298..348	CDD:278826	13/93 (14%)
		RCC1_2	393..422	CDD:290274	12/28 (43%)
		RCC1	409..452	CDD:278826	15/52 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900