DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Als2 and Rsph1

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_609609.1	Gene:	Rsph1 / 34712	FlyBaseID:	FBgn0032478	Length:	344	Species:	Drosophila melanogaster

Alignment Length:	320	Identity:	72/320 - (22%)
Similarity:	106/320 - (33%)	Gaps:	126/320 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   761 PDGSVYC-GELQHGIIEGFGKMVIPTTGLYVGNFKGGRFHGHGVYEMHCKDS------------- 811
            |:..:|. |....|..:|.|..::|....|.||::.||.||.|||..  ||.
  Fly    22 PNIGLYIGGRNAAGQRQGRGWAILPNGDQYDGNYRKGRRHGIGVYVF--KDGSRYYGQYRCGKRC 84

  Fly   812 -------PESEVYEGNFCEGLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFAD 869
                   |:..|||||:.:.|.||.|     ||.|                  |:||.|.|.:..
  Fly    85 GRGIFIYPDGSVYEGNWRKNLKHGKG-----RYKY------------------VNGDNYSGDWFK 126

  Fly   870 NKRSGI----------GSCITNR------GDYFEGSFS---------------GDDLTGSGVAVF 903
            .:|.|:          |.|::.|      .:...|.|.               .|:|..||.|||
  Fly   127 GQRHGVGIYHFNSGKDGCCLSVRMKATWNSNMRTGPFELYIGNEDKCTILHGIWDNLYPSGPAVF 191

  Fly   904 ENDYYYEGELTLLGPNGRGEYYMPSGDACGGSGAMGTGEFDDTCELIGNKM-----------FGQ 957
            .    :.....|||      |::|:  :..........|.:|..|.:.::|           |.|
  Fly   192 S----FNNRYLLLG------YFLPA--SYNMKAISNEDEMEDAEERLEDEMGEAEPMEPTLWFAQ 244

  Fly   958 LSGTWDTVRIQAGELVLNRRFPKYPSSLGRQVVDHNRKWRSLFNNFESDLANCTASTSSS 1017
            ....:|...:           |:.|..|...               :|:|:.|:.||..|
  Fly   245 EMAVYDFSLL-----------PQEPVPLAIS---------------DSELSVCSLSTEPS 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Rsph1	NP_609609.1	MORN	51..73	CDD:280628	12/23 (52%)
		MORN	72..93	CDD:197832	0/20 (0%)
		MORN	95..116	CDD:197832	12/43 (28%)
		MORN	118..137	CDD:197832	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900