DRSC/TRiP Functional Genomics Resources

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Protein Alignment Als2 and herc1

DIOPT Version :9

Sequence 1:NP_649347.1 Gene:Als2 / 40410 FlyBaseID:FBgn0037116 Length:1486 Species:Drosophila melanogaster
Sequence 2:XP_009301513.1 Gene:herc1 / 336598 ZFINID:ZDB-GENE-030131-8542 Length:4867 Species:Danio rerio


Alignment Length:1648 Identity:311/1648 - (18%)
Similarity:531/1648 - (32%) Gaps:505/1648 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 SGSQELFVVLTNGSVQRQATGS-GR----DVGHPHAWQTLGFDPLELHAEGVRIRRVCCSAQGVV 150
            :|....||:.::|||:....|| ||    |..:....:.|.|:|   |.   .|::|..|.    
Zfish   405 AGQYCTFVISSDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEP---HR---AIKKVSSSK---- 459

  Fly   151 FVGASGETYVMGSCGEVF---------------KAEQQPRHMRLYEEGKELLDLAAGNEHFVMLV 200
              |:.|.|....|.||||               ..::.|:.::...:||.::.::||..|     
Zfish   460 --GSDGHTLAFTSEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRH----- 517

  Fly   201 APYNLADDALQLSVASAKEEPE---------------DERAS-----VKSISSGHSERSVAANTR 245
                         .|:..|:.|               |..:.     ||.||:.......:::|.
Zfish   518 -------------SAAVSEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTI 569

  Fly   246 HLLHQGYALLHTQLFTFGASNNGLLGSGDHIRRANVMRLQKLDSMGVCSIAAGLEHTVARTLDGR 310
            .|...|     ..:::||..:||.||.||..|......::.|..|.:..:.||.:.::|.|..|:
Zfish   570 ALSKDG-----RTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGMFIRKVCAGSQSSLALTSTGQ 629

  Fly   311 LYHWGLNNHSQLGEDVSSPMEITITENTAALPIEQNSALEATCGDYHTLLLNASGQIHSLQPAPP 375
            :|.||.......|...::.:...:.|..|...:     ::.:.||.|.|.|:...::::......
Zfish   630 VYAWGCGACLGCGSSEATALRPKLIEELATTRV-----VDISIGDSHCLALSHDNEVYAWGNNSM 689

  Fly   376 MRHLQQSSTYAQT------------LLQLQLGA----AW---PRQLRLLMCSGGY-------TLQ 414
            .:..|.:||...|            :.|:..|.    ||   ||..:::.....|       |..
Zfish   690 GQCGQGNSTGPITKPKKVIGLDGVAIQQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFS 754

  Fly   415 NQRQFQRQY------------------HYYLSHLQSQLQLLLKH---------------RQA--- 443
            :.|.|..:|                  |:  :.|:..|:||..|               |||   
Zfish   755 HLRSFLERYCDGINNEIPPLPFPSSKEHH--NFLKLCLRLLSNHLALALAGGVATSILGRQARPL 817

  Fly   444 --------------------VQTLEIW---------QRQSALEPLSALGPLLINWERI------- 472
                                ::||.:.         :|...|..|...||  ..||.:       
Zfish   818 RNLLFRLMDASVPDEIQEAVIETLSVGATMLLPPLRERMELLHSLLPQGP--DRWESLSKGQRMQ 880

  Fly   473 LCLLVATLHSLEGFYRADFVQPADLLFICHYKEYIDLFDGYTKAYCDVFSVNGFGEAVVAITGLS 537
            |.:::.:|.        |....|.||             ||:   |.              ...|
Zfish   881 LDIILTSLQ--------DHTHVASLL-------------GYS---CP--------------PDAS 907

  Fly   538 SPLAELNEESYVTRLFQQPFSIYQLFVQFMELLVRTQSEYGEHRVAWSEFARHSCISQELAVNTK 602
            .|.|:.::.::|............|....|:.|:|....|.:.  |:.|..::   |.::...|.
Zfish   908 EPPAQPSDSTHVPGTHSDTHPDTHLAEILMKTLLRNLGFYTDQ--AFGELEKN---SDKILQGTS 967

  Fly   603 DFWSSNDRNPRIVQFRGRHRRVILTS------ALVPLKLVTSGIS--------------RSSNSF 647
               ||:...|       .|...:|.|      |...:..||.|.|              .:::.|
Zfish   968 ---SSDSSQP-------AHLHELLCSLQKQLLAYCHINSVTEGSSSVALLHKHLQLLLPHATDIF 1022

  Fly   648 ILFSDFLCQVSGN-----------------SLYSYPLTTLW---VWTEGDSLRLTTPEKSFLVST 692
            ...:..|.:.|||                 |:....:|:|.   ||       :..|..|||:..
Zfish  1023 NRSATLLRESSGNGSVREKLRDVIYMSAAGSMLCQIVTSLLLLPVW-------VARPLLSFLLDL 1080

  Fly   693 RSQEMRKVWLDQLQSSIIASLGKPLGSPVPSYRSTGYEFSREHPKFSRVKACGTWRKGVLHGN-- 755
            ...      ||:|...:      |..:|:.       |...:.|               |||:  
Zfish  1081 LPP------LDRLNKLL------PAATPLE-------EQELQWP---------------LHGSPD 1111

  Fly   756 -----CYLEYPDGSVYCGELQHGIIEGFGKMVIPTTGLYVGNFKGGRFHG-----HGVYEMHCKD 810
                 |........|:..:|:.            |..|.||...||...|     ...:..|...
Zfish  1112 LVDPVCVSGPAQSWVWLVDLER------------TAALLVGRCLGGMLQGAAPSAEEQHTTHWLK 1164

  Fly   811 SP------ESEVYEGNFC-----EGLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYM 864
            :|      |:|:.:.:.|     |....|:...|        .:....|:...|:.||..|    
Zfish  1165 TPLFSNGLETEIPQLDACISSLLEVALCGNEEQR--------PFDCQLRADMSVLVDLALG---- 1217

  Fly   865 GMFADNKRSGIGSCITNRGDYFEGSFSGDDLTGSGVAVFENDYYYEGE-----LTLLGPNGRGEY 924
                 :.:....|..:|..||   :.|.|..:.|    ..|:...:..     ..||...|.   
Zfish  1218 -----STKEPTHSLWSNMQDY---AISKDWDSAS----LPNEALLDTVSRFVLAVLLKHTGL--- 1267

  Fly   925 YMPSGDACGGSGAMGTGEFDDTCELIGN------KMFGQLSGTWDTVRIQAGELVLNRRFPKYPS 983
               .|.||      |.|.: ..|:|:..      |:..:|....:...||.......||......
Zfish  1268 ---LGQAC------GEGRY-QPCKLLAEVYRSVYKVRNRLLACKNMELIQTRSSSRERRISDNVD 1322

  Fly   984 SLGRQVVDHNRKWRSLFNNFESDLANCTASTSSSGGNQSAGTLRKSSKPTLSTA-QIWNCIAVYM 1047
            |:.....:|:.. |::  :.|::|...........|:|......:..:..:.|| :|:.|.....
Zfish  1323 SVEMDPQEHSFT-RTI--DEEAELEERDREREREEGHQEQEDEEEEREHEVMTAGKIFQCFLSAR 1384

  Fly  1048 SKQRAREGTKPGNYFNNILLSLPLP----QKTSSPLAKARTTTSALSKLQTEAASALDFLGFPPR 1108
            ...|.|:..:.|:.  ::....|.|    :.:|:|.......|::.:.:....|..|..|..|  
Zfish  1385 EAARGRDRDRTGSM--SVQEEPPQPGPERRNSSTPQEGQDLYTTSCNAVIHRCAMLLLALSTP-- 1445

  Fly  1109 RIQSQEALNSKP----------GGLQRADSLISMGHNTSRDLDNSSLASFQLDQSLMNSTVNGDE 1163
               ..:.:|.:|          |.:.|::||.:    .||.:.:|  .|.:|.:|...|.::..|
Zfish  1446 ---LAQHINQQPLTGGVNQDGVGFMTRSESLSA----ESRSIHSS--PSCRLTKSRSESDLSQPE 1501

  Fly  1164 SSTFNESFSKLSHNNNNSISKHMNNIDCSITSTTSTTSAVLDQVPS----FGMALV-----LTEQ 1219
            |.  .|.:|..:.          .|:|..:..|......:.....|    ||..|.     .::|
Zfish  1502 SD--EEGYSLNAR----------RNVDLDLAFTPKKRGFLYSSPDSSADWFGGRLARECFYSSQQ 1554

  Fly  1220 DVTSIRLYLEQAFKDRHHPLYVLNERIANCFHYSYGYWKVKPTPILAKQAMRE-WESISRRIYRF 1283
            ......|.|.|:.:     |:.|.|.|.|......|          ...|.:| .||:|..    
Zfish  1555 SYDESDLDLNQSLR-----LHALIENIVNFISGDVG----------NAPAFKEPEESVSTS---- 1600

  Fly  1284 VRKMFPALPEELCQMEGSREVISHITLLYPLVLSEGIYSTLFVLYANKYSRKDEMYRQNLNLAEK 1348
            .:.:..|:.::..:.|...|.:..|     :||..|:...  ...|...:.:..:...:.:|...
Zfish  1601 PQAIIIAMEQQQSRAELRLEALHQI-----VVLISGMEEK--SSQAGSGAGRTGLSFHSASLLTS 1658

  Fly  1349 LKDQELVELMGHESFLH------NVMLDPKFVESVQTLKELQEKFSPQDMLTVIQRSTQLLTEAY 1407
            ::.|.|....|..:..:      ||.|. .:.:.|:..|    |....::.|.:.:..|.|:...
Zfish  1659 VRLQFLSGCFGLGAVSYGGPKGENVQLH-HYQDGVRAAK----KSLQMEIQTAVHKIYQQLSVTL 1718

  Fly  1408 EHAMAANAAQLNADNMIPLTMLTMLRAAVPHLGAELAL-------LDDLTG-----GPNFQAEMN 1460
            |.|:.||...:.|...:.|..:..|......:...||:       |..|.|     |...|....
Zfish  1719 ERALQANKHHIEAQQRLLLVTVFALSVRYQPVDVSLAISSGLLDVLSQLCGTETLLGQTLQLLQK 1783

  Fly  1461 GMAGYCYTTLKAAYEHVTSRALQ 1483
            .......|.||.|    ::|.||
Zfish  1784 PAGSQLSTALKVA----STRLLQ 1802

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Als2NP_649347.1 RCC1 258..304 CDD:278826 13/45 (29%)
RCC1_2 292..321 CDD:290274 8/28 (29%)
RCC1 308..361 CDD:278826 11/52 (21%)
PH-like 616..715 CDD:302622 25/138 (18%)
VPS9 1373..1479 CDD:280383 24/117 (21%)
herc1XP_009301513.1 RCC1 369..726 CDD:332518 76/360 (21%)
SPRY_HERC1 2004..2161 CDD:293939
UBA_HERC1 2729..2772 CDD:270584
WD40 3406..3773 CDD:330360
WD40 repeat 3419..3452 CDD:293791
WD40 repeat 3479..3514 CDD:293791
WD40 repeat 3527..3569 CDD:293791
WD40 repeat 3575..3611 CDD:293791
WD40 repeat 3618..3660 CDD:293791
WD40 repeat 3665..3710 CDD:293791
WD40 3737..>3831 CDD:330360
WD40 repeat 3749..3784 CDD:293791
RCC1 4004..4351 CDD:332518
HECTc 4479..4847 CDD:238033
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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